In a first of its kind study, researchers from Columbia's Rafael Yuste's Laboratory used cellular resolution in vivo two-photon calcium imaging in mice to investigate changes in the local repertoire of neuronal micro states during anesthesia. The team found that anesthesia disrupts the number of neural patterns by reducing both network micro states and neuronal ensembles in the cortex, and confirmed their findings in micro electrode array recordings from two human subjects. Their results are published today in the journal 'Cell Systems.'
