Researchers have identified a new HIV vaccine delivery strategy, which provides small doses over series of days leading to stronger immune response than when the same vaccine is given all at once.A new study demonstrates that changing a vaccine's delivery, not the vaccine itself, can have dramatic results on its success."If you change the way the immune system sees viral proteins, it really can make a dramatic difference," said Shane Crotty, leader of the study published in the Journal of Cell.Researchers compared three vaccine dosage strategies to see if one might stand a better chance of prompting neutralizing antibody production.They tested the strategies in rhesus monkeys, the best animal model for studying how the human immune system reacts to HIV.Firstly, the team needed a window into the immune system. The researchers took advantage of a new technique, adapted recently, to repeatedly extract small samples of germinal center cells from the lymph nodes.This enabled them to see ...
