Using Multi-Walled Carbon Nanotubes (MWCNTs) as a drug delivery system, can avoid the need for solvents and preventing drug precipitation in aqueous solution. Soyasapogenol B (SSB) acts as an important therapeutic agent owing to its numerous reported biological activities.
Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d'Etudes Nucléaires de Bordeaux Gradignan (CNRS/Université de Bordeaux) have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport. This work, carried out with colleagues at the University of Texas at Austin (USA), was published in ACS Chemical Neuroscience on January 16, 2018.
More than 100 years after the introduction of the Haber-Bosch process, scientists continue to search for alternative ammonia production routes that are less energy demanding. Chinese scientists have now discovered that black phosphorus is an excellent catalyst for the electroreduction of nitrogen to ammonia. According to their study published in the journal Angewandte Chemie, layered black phosphorus nanosheets are a highly selective and efficient catalyst in this process.
The authors demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some... Читать дальше...
Base metal catalyzed regioselective cage B-H functionalization has been achieved. Under the assistance of a bidentate directing group, Cu-catalyzed [4+2] annulation of carboranyl amides with internal alkynes affords unprecedented C,B-substituted carborane-fused-pyridone derivatives, whereas the use of terminal alkynes leads to B-H/C(sp)-H dehydrocoupling products. The isolation and structural identification of a notably stable Cu(I) intermediate shed light on the reaction mechanism, which is proposed to involve a Cu(III) intermediate.
Dr. Teruyoshi Kobayashi of Kobe University and his team developed a new method for identifying individuals that have essential connections between them -- what they call 'significant ties'. Dr. Kobayashi says: "The point is that we need to distinguish between the contact events that could happen by chance and the events that would not happen without a significant relationship between two individuals." Their findings were published in Nature Communications on January 15.
Two newly developed methods will help researchers to study the 3D structure of complex surfaces and of individual neurons better than ever before. Sebastian Munck and Natalia Gunko, two expert technologists at VIB-KU Leuven, report new imaging protocols that will advance neuroscience and (bio)imaging in general.
Chaos in bodily regulation can optimize our immune system according to a recent discovery made by researchers at the University of Copenhagen's Niels Bohr Institute. The discovery may prove to be of great significance for avoiding serious diseases such as cancer and diabetes.
Nudging, the concept of influencing people's behavior without imposing rules, bans or coercion, is an idea that government officials and marketing specialists alike are keen to harness, and itis often viewed as a one-size-fits-all solution. Now, a study by researchers from the University of Zurich puts things into perspective: Whether a nudge really does improve decisions depends on a person's underlying decision-making process.
Products transported by sea in containers are often fumigated with biocides as protection against pests. In addition to this, they often contain volatile organic solvents, such as the potentially carcinogenic 1,2-dichloroethane, which can originate from cleaning or manufacturing processes.In a meeting held at the German Federal Institute for Risk Assessment (BfR) on 16 November 2018, 36 experts from science, monitoring authorities, trade and industry discussed the effects of substances of this kind on health... Читать дальше...
A University of Southampton research team has developed a map of chemicals found in Jellyfish caught across 1 million square-kilometres of UK waters. The same chemicals are found in other marine animals such as birds and fish.These findings can support conservation efforts by helping track an animals movements and also be used as a tool to detect food fraud by identifying where seafood products were sourced from.
The German Federal Institute for Risk Assessment (BfR) already prepared the first draft of its health assessment of glyphosate (RAR) in 2013. Since then the BfR has received repeated inquires foremost regarding the independence of the European institutions and the assessment procedure.
Whale sharks, the world's largest fish, likely endure periods of starvation and may eat more plants than previously thought, according to the first results of a new health check developed at the University of Tokyo. Ocean scientists now have a powerful, simple tool to discover the diets, migrations, and conservation needs of this endangered species.
A Michigan State University study is the first to show an association between unusually high pesticide exposure and poor sense of smell among aging farmers.
Researchers from Kumamoto University in Japan measured the ketone body utilization rate in the heart and confirmed that it decreases when the heart is in a state of reduced blood flow (myocardial ischemia).
A study finds a surprising response to cocaine in a novel strain of mutant mice -- they failed to show hyperactivity seen in normal mice when given cocaine and didn't run around. In other tests, they still found cocaine appealing, but displayed an inability to shake the memory of cocaine's actions when the drug was no longer administered. The key change that blocks cocaine's stimulant effects in these mice is serotonin, not dopamine, which is responsible for producing a high.
It's no surprise to scientists that variety is the very essence of biology, not just the seasoning, but most previous studies of key brain cells have found little variability in a common cell process that involves how genetic information is read and acted on.
Drinking bone broth is a recent diet fad that proponents claim fights inflammation, eases joint pain and promotes gut health. Simmering animal bones in water releases collagen and other proteins into the broth that may have health benefits, although more research is needed to validate these claims. Now, a new study in ACS' Journal of Agricultural and Food Chemistry has shown that ham bones contain peptides that could have cardioprotective effects.
(University of York) The United Republic of Tanzania has announced it will protect a globally unique forest ecosystem in East Africa, following research that demonstrated it is under threat from illegal activities including tree-cutting for charcoal and the poaching of elephants and other animals.
There are a lot of silk pillowcases out there that promise smooth hair and blemish-free skin, but not many of them are black and machine-washable.
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Police have issued images of two men they wish to identify
The world's longest bridge by Hyundai E&C and Combined Group Contracting is nearing completion in Kuwait. Called the Sheikh Jaber Al-Ahmed Al-Sabah causeway, the $3 billion project is one of the largest infrastructure projects in the world. Running a total length of over 30 miles, the bridge will connect Kuwait City on the south of the bay with Subiya New Town to the north. The causeway joins a larger development plan for the revival of the ancient Silk Road trade route.