TNFα-induced cell death is tightly regulated and resisted in endothelial cells. Here, an Osaka University-led research team used a unique type of mouse, in which TAK1 could be deleted in specific tissues, to show that TAK1 is an essential component in ensuring survival of endothelial cells during inflammation and injury, and that TAK1 could be a novel target for anti-angiogenic therapy in cancer treatment.
Recently, researchers at the Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, in collaboration with colleagues, demonstrated that fever promotes T lymphocyte trafficking through heat shock protein 90 (Hsp90)-induced α4 integrin activation and signaling in T cells.
Recently, an international team led by Dr. CAI Chenyang, from the Nanjing Institute of Geology and Palaeontology of the Chinese Academy of Sciences, reported two new and rare species of the extant family Clambidae from Burmese amber: Acalyptomerus thayerae Cai and Lawrence, 2019, and Sphaerothorax uenoi Cai and Lawrence, 2019. They are important for understanding the early evolution and biogeography of the family and even for polyphagan beetles.
Millions of people have contracted Zika and chikungunya virus infections since the outbreaks that have been striking Latin America since 2013. Particularly Zika-related malformations in newborns warrant reliable diagnostics. DZIF scientists from the Charité - Universitätsmedizin Berlin demonstrate the problems with the currently available diagnostics, particularly for Zika virus detection, and develop combined testing methods that have higher reliability.
A recent high pressure study on the type II Dirac Semimetal (DSM) PtTe2 reveals a pressure induced Lifshitz transition in the trivial band structure, while the crystal structure keeps robust under pressure.
Permafrost, is an element of the cryosphere which has not been as much studied as other soils like glaciers or marine ice. Now, for the first time, a review of the state of permafrost on Earth has been carried out thanks to the data analysis of more than 120 drillings distributed around the Arctic and the Antarctica, as well as in mountains and high plains worldwide.
Kanazawa University researchers discovered that the distance between dislocations in nanolayer interfaces of pearlite can determine how much the material can stretch or contract without breaking (ductility). The dislocations are disruptions in the regular arrangements of atoms in nanolayers. This discovery opens the possibility of engineering materials with higher ductility by simply manipulating the spacing between their dislocations and may improve the safety of structures such as buildings and bridges in earthquakes.
A survey of 20 disadvantaged neighborhoods across the North West (UK) has revealed the social influences on why people attend their local Accident & Emergency department.
There is a consistently high level of public support across nations for a global carbon tax if the tax policy is carefully designed, according to a survey of people in the United States, India, the United Kingdom, South Africa and Australia.
New research suggests that drinking sugary, caffeinated soft drinks while exercising in hot weather may increase the risk of kidney disease. The study is published ahead of print in the American Journal of Physiology--Regulatory, Integrative and Comparative Physiology.
(Woods Hole Oceanographic Institution) New research by the Woods Hole Oceanographic Institution (WHOI) and colleagues reveals the previously unknown behaviors of juvenile Emperor penguins in their critical early months when they leave their birth colony and first learn how to swim, dive, and find food.
Mindfulness may be associated with fewer menopausal symptoms for women, according to a Mayo Clinic study recently published in Climacteric: The Journal of the International Menopause Society. Researchers discovered that being mindful may be especially helpful for menopausal women struggling with irritability, anxiety and depression.
CCTV still of Mrs Morgan entering Morrisons supermarket in Honeypot Lane, Queensbury NW9 at around 11:00hrs on Thursday, 15 January 2009
Ten years on from the murder of an elderly woman detectives continue to appeal for witnesses and information
Using risk assessments, like those used for setting occupational safety limits in the workplace, researchers determined the winners and losers of climate change in the Antarctic. They show that marine animals associated with sea ice for food or breeding, such as some whales and penguins, are most at risk from the effects of climate change, while seafloor predators and open-water feeding animals like starfish and jellyfish will benefit from the opening up of new habitat.
The number of Americans taking a dangerous combination of both opioids and benzodiazepines -- a group of drugs commonly prescribed for pain, insomnia and anxiety -- increased by 250 percent over a 15-year period, while there was an 850 percent increase in patients taking benzodiazepines and so-called Z-drugs, according to a new study published in the journal Sleep.
Researchers in the Department of Zoology at Oxford University have demonstrated for the first time what effect female fruit flies having multiple partners has on sexual selection -- before and after mating. Sexual selection is the branch of natural selection concerned with obtaining mates and fertility, rather than survival.
New York City's famed Chrysler Building is up for sale for the first time in over 20 years. According to the Wall Street Journal, the art deco office tower’s current owners officially placed it on the market, though the building's value has yet to be released. Designed by William Van Alen, the building was bought by Tishman Speyer in 1997. As an iconic part of the New York skyline, the building is admired for its distinctive ornamentation based on Chrysler automobiles.
A MURAL depicting five of Sunderland AFC’s best-known captains has been unveiled at the Stadium of Light.
IT remains to be seen if Rafa Benitez will now feel like he can trust more of his academy graduates in the Premier League after a successful night for the Newcastle United production line in the FA Cup.
Currently approximately 600 species might be inaccurately assessed as non-threatened on the Red List of Threatened Species. More than a hundred others that couldn't be assessed before, also appear to be threatened. A new more efficient, systematic and comprehensive approach to assess the extinction risk of animals has shown this. The method, designed by Radboud University ecologist Luca Santini and colleagues, is described in Conservation Biology on Jan. 17.