Identification of the X-linked germ cell specific miRNAs (XmiRs) and their functions
by Hiromitsu Ota, Yumi Ito-Matsuoka, Yasuhisa Matsui
MicroRNAs (miRNAs) play a critical role in multiple aspects of biology. Dicer, an RNase III endonuclease, is essential for the biogenesis of miRNAs, and the germ cell-specific Dicer1 knockout mouse shows severe defects in gametogenesis. How miRNAs regulate germ cell development is still not fully understood. In this study, we identified germ cell-specific miRNAs (miR-741-3p, miR-871-3p, miR-880-3p) by analyzing published RNA-seq data of mouse. Читать дальше...