Новости за 05.03.2019

To the Editor Drs Tchkonia and Kirkland discussed emerging therapeutic strategies for age-related disorders as a group (ie, senolytic therapies).

In Reply Dr Tsai and colleagues cite a guideline on pharmacotherapy for obesity and state that the USPSTF should have addressed pharmacotherapy in its recommendation on adult obesity. According to the authors, pharmacotherapy should be considered for long-term use because obesity is defined as a chronic disease.

In Reply We agree with the points raised by Dr O’Sullivan and colleagues about our Viewpoint, including their comments about implications of targeting senescent cells at different stages during development and aging, intermittent hit-and-run dosing, cancer control, wound healing, and fibrosis.

In Reply Dr Hurley suggests endotoxin may not play a role in septic shock, leading to the disappointing outcomes of the EUPHRATES trial. We agree that endotoxin is simply one of many potential mediators of septic shock, although the human evidence that it can cause the condition is incontrovertible. We enriched our population of patients with elevated endotoxin levels through the use of the endotoxin-activity assay, targeting only those with activity levels greater than 0.6. We also agree that endotoxemia... Читать дальше...

This 2 × 2 factorial randomized clinical trial tests 2 nutritional strategies—multinutrient supplementation and food-related behavioral activation therapy—reduces major depressive disorder (MDD) over a year among overweight or obese European adults with elevated symptoms but without an MDD episode found neither approach reduced the number of episodes.

This randomized clinical trial tests the hypothesis that an integrated collaborative care intervention would significantly improve both obesity and depression at 12 months compared with usual care in adults with body mass indices of 30 or greater (≥27 for Asian adults) and 9-item Patient Health Questionnaire scores of 10 or greater.

This open-label, randomized clinical trial examined the effect of a behavioral intervention that included theoretical and practical counseling sessions vs general physician recommendations to increase physical activity on physical activity and sedentary time in participants with type 2 diabetes.

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This narrative medicine essay uses an instance when the physician-author’s elderly mother was screened for intimate partner violence to discuss electronic health record (EHR) ‘hard stops,’ an EHR function that forces a response before a visit can proceed as an implementation of CMS ‘meaningful use’ that, the author claims, is neither meaningful nor useful and possibly harmful.

The U.S. Food and Drug Administration (FDA) accepted Celgene’s New Drug Application (NDA) for fedratinib for myelofibrosis. It also granted it a Priority Review, with a target action date of September 3, 2019.

San Diego-based Pacira Pharmaceuticals, a specialty pharmaceutical company, plunked down $220 million to acquire medical device company Myoscience and its non-opioid pain treatment system iovera.

After five years at the reins, Mike Taylor will step down from his role as president and chief executive officer of Waltham, Mass.-based Deciphera Pharmaceuticals. Taylor’s last day in the role will by March 18, the company announced late Monday.

With Boston and the surrounding area being one of the centers of the pharmaceutical world, it should come as no surprise that some of the top-selling medications are based in the Bay State.

As Purdue Pharma grapples with multiple lawsuits over its OxyContin pain killer, there are reports that the drugmaker is exploring bankruptcy as a legal defense mechanism.

Scott Gottlieb, the proactive commissioner of the U.S. Food and Drug Administration has resigned, according to reports. Gottlieb will leave the regulatory agency in about a month.

Event On 5 March, the Pakistan Navy released a video that purportedly showed an Indian submarine on the surface near Pakistani territorial waters in the Arabian Sea one day earlier. Separately, on 4 March unconfirmed Indian media reports claimed that an Indian Air Force (IAF) Sukhoi-30 fighter jet

The US military has deployed a Terminal High Altitude Area Defense (THAAD) system to Israel for the first time, US European Command (EUCOM) and the Israeli Air Force (IAF) announced on 4 March. EUCOM said the system was from the Texas-based 11th Air Defense Artillery Brigade and described the

The Portuguese Air Force has just deployed fighter jets to Malbork Air Base in Poland as part of NATO’s European Deterrence Initiative. Four Lockheed Martin F-16AM Fighting Falcon aircraft and about 70 personnel from the 5st Operational Group, based out of Monte Real Air Base, were deployed

Key Points A security conference hosted in Odessa has laid bare the lack of any firm NATO strategy for the Black Sea region NATO is struggling to work out how to shield its allies in the region from further Russian aggression Despite five years of hand-wringing over Russia’s annexation of

Kuwait has postponed signing a contract with Russia for T-90MS tanks, the Xinhua News Agency cited the head of the Kuwaiti Armament and Equipment Authority as saying on 5 March. Anwar al-Mazidi, who was speaking at a reception organised by the Russian embassy in Kuwait, added that the tank

Key Points The US Air Force hopes better software development will improve the speed of acquisition One software programme, ALIS, has contributed to high F-35 sustainment costs US Air Force (USAF) leadership is betting that better software development practices will help improve aircraft

When it comes to the US military presence in Europe, the nation is not prepared to deter Russian aggression, and additional land, maritime, and intelligence, surveillance, and reconnaissance (ISR) assets are needed, according to the head of US European Command (USEUCOM) General Curtis Scaparrotti.

NATO, the European Union, and partners in the Black Sea region are ardently searching for solutions to prevent Moscow’s blockage of the Azov Sea becoming permanent but with little to show for it so far. Ideas range from throwing together a new multi-lateral surveillance system for tracking

Turkish vice president Fuat Oktay has revealed that the country’s defence industry is now fulfilling 65% of domestic military equipment needs. Speaking at a conference held by Turkish Aerospace on 2 March, Turkey’s Hurriyet Daily quoted the vice president as saying that “it is