Добавить новость
ru24.net
News in English
Календарь
Апрель
2019
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30

Новости за 30.04.2019

151050100500100011511152115311541155 >>>

Effects of exercise programs on kyphosis and lordosis angle: A systematic review and meta-analysis

Plos.org 
En

by Noelia González-Gálvez, Gemma M. Gea-García, Pablo J. Marcos-Pardo

Many authors are interested in the effects that a specific exercise program could have on sagittal spinal curvatures. The purpose of this study was to determine the effects of different exercise programs on thoracic kyphosis and lumbar lordotic angle. This meta-analysis adhered to the PRISMA guideline and it was registered at PROSPERO. Five electronic databases (Pub Med, Cochrane, WOS, PEDro and EBSCO) were searched up to 31 July 2018. Читать дальше...

Whole body glucoregulation and tissue-specific glucose uptake in a novel Akt substrate of 160 kDa knockout rat model

Plos.org 
En

by Edward B. Arias, Xiaohua Zheng, Swati Agrawal, Gregory D. Cartee

Akt substrate of 160 kDa (also called AS160 or TBC1D4) is a Rab GTPase activating protein and key regulator of insulin-stimulated glucose uptake which is expressed by multiple tissues, including skeletal muscle, white adipose tissue (WAT) and the heart. This study introduces a novel rat AS160-knockout (AS160-KO) model that was created using CRISPR/Cas9 technology. We compared male AS160-KO versus wildtype (WT) rats for numerous metabolism-related endpoints. Читать дальше...

The effect of air pollution on convenience-based or other-oriented lies

Plos.org 
En

by Song Wu, Tingbin Wang

Besides endangering human health, air pollution has profound effects on individuals’ cognition, emotions, and behavior. Previous studies have found that air pollution could increase self-oriented lies. We summarized two explanations for this phenomenon: (1) air pollution makes people less likely to regard lies as unethical, and (2) air pollution makes people more likely to approach materials rewards. The present study mainly measured three kinds of lies—self-convenience... Читать дальше...

A protein self-assembly model guided by electrostatic and hydrophobic dipole moments

Plos.org 
En

by Angel Mozo-Villarías, Enrique Querol

Protein self-assembling is studied under the light of the Biological Membrane model. To this purpose we define a simplified formulation of hydrophobic interaction energy in analogy with electrostatic energy stored in an electric dipole. Self-assembly is considered to be the result of the balanced influence of electrostatic and hydrophobic interactions, limited by steric hindrance as a consequence of the relative proximity of their components. Our analysis... Читать дальше...

Vitamin D status and risk of non-Hodgkin lymphoma: An updated meta-analysis

Plos.org 
En

by Hye Yin Park, Yun-Chul Hong, Kyoungho Lee, Jaewoo Koh

Purpose

This meta-analysis aimed to extensively investigate the association between various measures of vitamin D status and non-Hodgkin lymphoma (NHL) and its subtypes.

Methods

We searched MEDLINE (PubMed), Embase, and the Cochrane Library in February 2018. Two authors independently reviewed and selected articles based on predetermined criteria.

Results

A total of 30 studies with 56,458 NHL cases were finally selected... Читать дальше...

Involvement of placental growth factor upregulated via TGF-β1-ALK1-Smad1/5 signaling in prohaptoglobin-induced angiogenesis

Plos.org 
En

by Mi-Kyung Oh, In-Sook Kim

A potential role of haptoglobin in arterial restructuring has been suggested, and our previous study demonstrated that prohaptoglobin, the precursor of haptoglobin, stimulates endothelial angiogenesis. However, the mechanisms underlying the angiogenic effects of prohaptoglobin are still unclear. Here, we investigated angiogenic signaling induced by prohaptoglobin using human umbilical vein endothelial cells. Prohaptoglobin upregulated the expression of placental growth factor (PlGF)... Читать дальше...



Associations among circulating levels of follistatin-like 1, clinical parameters, and cardiovascular events in patients undergoing elective percutaneous coronary intervention with drug-eluting stents

Plos.org 
En

by Tatsuro Aikawa, Kazunori Shimada, Katsumi Miyauchi, Tetsuro Miyazaki, Eiryu Sai, Shohei Ouchi, Tomoyasu Kadoguchi, Mitsuhiro Kunimoto, Yusuke Joki, Tomotaka Dohi, Shinya Okazaki, Kikuo Isoda, Koji Ohashi, Toyoaki Murohara, Noriyuki Ouchi, Hiroyuki Daida

Читать дальше...

Knowledge, attitudes and practices (KAP) towards rabies and free roaming dogs (FRD) in Panchkula district of north India: A cross-sectional study of urban residents

Plos.org 
En

by Harish Kumar Tiwari, Ian D. Robertson, Mark O’Dea, Abi Tamim Vanak

Canine rabies is endemic in urban India. A questionnaire was administered to 204 residents of the urbanised municipality of Panchkula in north India to assess the influence of gender, age, family size, social status and dog ownership, over the knowledge, attitudes and practices (KAP) towards rabies control and free-roaming dogs (FRD) in their locality. Bivariate analyses revealed significant knowledge gaps regarding crucial... Читать дальше...

FunSPU: A versatile and adaptive multiple functional annotation-based association test of whole-genome sequencing data

Plos.org 
En

by Yiding Ma, Peng Wei

Despite ongoing large-scale population-based whole-genome sequencing (WGS) projects such as the NIH NHLBI TOPMed program and the NHGRI Genome Sequencing Program, WGS-based association analysis of complex traits remains a tremendous challenge due to the large number of rare variants, many of which are non-trait-associated neutral variants. External biological knowledge, such as functional annotations based on the ENCODE, Epigenomics Roadmap and GTEx projects, may be... Читать дальше...

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

Plos.org 
En

by Dov Tiosano, Hagit N. Baris, Anlu Chen, Marrit M. Hitzert, Markus Schueler, Federico Gulluni, Antje Wiesener, Antonio Bergua, Adi Mory, Brett Copeland, Joseph G. Gleeson, Patrick Rump, Hester van Meer, Deborah A. Sival, Volker Haucke, Josh Kriwinsky, Karl X. Knaup, André Reis, Nadine N. Hauer, Emilio Hirsch, Ronald Roepman, Rolph Pfundt, Christian T. Thiel, Michael S. Wiesener, Mariam G. Aslanyan, David A. Buchner

Читать дальше...

Новости России

Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis

Plos.org 
En

by Xiaokang Wang, Xudong Chen, Linhua Sun, Weiqiang Qian

As a component of the Cytosolic Iron-sulfur cluster Assembly (CIA) pathway, DRE2 is essential in organisms from yeast to mammals. However, the roles of DRE2 remain incompletely understood largely due to the lack of viable dre2 mutants. In this study, we successfully created hypomorphic dre2 mutants using the CRISPR/Cas9 technology. Like other CIA pathway mutants, the dre2 mutants have accumulation of DNA lesions and show constitutive DNA damage response. Читать дальше...

Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila

Plos.org 
En

by Yuya Ohhara, Aki Nakamura, Yuki Kato, Kimiko Yamakawa-Kobayashi

Endocycle is a commonly observed cell cycle variant through which cells undergo repeated rounds of genome DNA replication without mitosis. Endocycling cells arise from mitotic cells through a switch of the cell cycle mode, called the mitotic-to-endocycle switch (MES), to initiate cell growth and terminal differentiation. However, the underlying regulatory mechanisms of MES remain unclear. Here we used the Drosophila steroidogenic organ... Читать дальше...

Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress

Plos.org 
En

by Lei Zhou, Bin He, Jianhui Deng, Shanshan Pang, Haiqing Tang

Early exposure to some mild stresses can slow down the aging process and extend lifespan, raising the question of how early life stress might impact the somatic health of aged animals. Here, we reveal that early life heat experience triggers the establishment of epigenetic memory in soma, which promotes long-lasting stress responses and longevity in C. elegans. Unlike lethal heat shock, mild heat activates a unique transcriptional... Читать дальше...

The nonlinear dynamics and fluctuations of mRNA levels in cell cycle coupled transcription

Plos.org 
En

by Qiwen Sun, Feng Jiao, Genghong Lin, Jianshe Yu, Moxun Tang

Gene transcription is a noisy process, and cell division cycle is an important source of gene transcription noise. In this work, we develop a mathematical approach by coupling transcription kinetics with cell division cycles to delineate how they are combined to regulate transcription output and noise. In view of gene dosage, a cell cycle is divided into an early stage S 1 and a late stage S 2. The analytical forms for the mean... Читать дальше...


Спорт в России и мире

Новости спорта


Новости тенниса






Спонсорский контент

Все новости smi24.net