Age-related Macular Degeneration (AMD) is one of the major vision-threatening diseases of the eye. Oxidative stress is one of the key factors in the onset and progression of AMD. In this study, metabolites associated with AMD pathology more so at the systemic level namely, oxidized LDL (oxLDL), homocysteine (Hcy), homocysteine thiolactone (HCTL), advanced glycation end product (AGE) were evaluated for their pro-oxidant nature... Читать дальше...

Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells

15.05.2019 00:00

Plos.org

by Oula K. Dagher, Miran A. Jaffa, Aïda Habib, Fuad N. Ziyadeh, Ayad A. Jaffa

Nagaland health assessment: High mortality rates and difficulty accessing essential health services in Lahe Township, Republic of the Union of Myanmar

15.05.2019 00:00

Plos.org

by Win Le Shwe Sin Ei, Than Lwin Tun, Chit Htun, Etienne Gignoux, Kyaw Thu Swe, Andrea Incerti, Derek C. Johnson

Role of mechanical and thermal damage in pericapsular inflammatory response to injectable silicone in a rabbit model

15.05.2019 00:00

Plos.org

by Joon Seok, Soo Hyun Woo, Tae Rin Kwon, Jong Hwan Kim, Guk Jin Jeong, Kapsok Li, Woo Seob Kim, Beom Joon Kim

Selected serum microRNA, abdominal aortic calcification and risk of osteoporotic fracture

15.05.2019 00:00

Plos.org

by Marie-Eva Pickering, Marjorie Millet, Jean-Charles Rousseau, Martine Croset, Pawel Szulc, Olivier Borel, Elisabeth Sornay Rendu, Roland Chapurlat

Incidence, features, and prognosis of immune-related adverse events involving the thyroid gland induced by nivolumab

15.05.2019 00:00

Plos.org

by Ichiro Yamauchi, Akihiro Yasoda, Shigemi Matsumoto, Yuichi Sakamori, Young Hak Kim, Motoo Nomura, Atsushi Otsuka, Toshinari Yamasaki, Ryoichi Saito, Morimasa Kitamura, Toshio Kitawaki, Masakatsu Hishizawa, Nobuko Kawaguchi-Sakita, Toshihito Fujii, Daisuke Taura, Masakatsu Sone, Nobuya Inagaki

A community-based system dynamics approach suggests solutions for improving healthy food access in a low-income urban environment

15.05.2019 00:00

Plos.org

by Yeeli Mui, Ellis Ballard, Eli Lopatin, Rachel L. J. Thornton, Keshia M. Pollack Porter, Joel Gittelsohn

Biomarker profiles of Alzheimer’s disease and dynamic of the association between cerebrospinal fluid levels of β-amyloid peptide and tau

15.05.2019 00:00

Plos.org

by Aysha S. Mohamed Lafirdeen, Emmanuel Cognat, Severine Sabia, Claire Hourregue, Matthieu Lilamand, Aline Dugravot, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Jacques Hugon, Archana Singh-Manoux, Claire Paquet, Julien Dumurgier

Limiting global warming to 1.5 to 2.0°C—A unique and necessary role for health professionals

15.05.2019 00:00

Plos.org

by Edward W. Maibach, Mona Sarfaty, Mark Mitchell, Rob Gould

In an Editorial, Edward Maibach and colleagues discuss the important role of health professionals in future responses to threats of climate change.

Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals

15.05.2019 00:00

Plos.org

by Hanna Shin, Christian Braendle, Kimberly B. Monahan, Rebecca E. W. Kaplan, Tanya P. Zand, Francisca Sefakor Mote, Eldon C. Peters, David J. Reiner

A long noncoding RNA distributed in both nucleus and cytoplasm operates in the PYCARD-regulated apoptosis by coordinating the epigenetic and translational regulation

15.05.2019 00:00

Plos.org

by Hui Miao, Linlin Wang, Haomiao Zhan, Jiangshan Dai, Yanbo Chang, Fan Wu, Tao Liu, Zhongyu Liu, Chunfang Gao, Ling Li, Xu Song

Correction: The AGC protein kinase UNICORN controls planar growth by attenuating PDK1 in Arabidopsis thaliana

15.05.2019 00:00

Plos.org

by Sebastian Scholz, Janys Pleßmann, Balaji Enugutti, Regina Hüttl, Katrin Wassmer, Kay Schneitz

Interacting cells driving the evolution of multicellular life cycles

15.05.2019 00:00

Plos.org

by Yuanxiao Gao, Arne Traulsen, Yuriy Pichugin

Evolution of complex multicellular life began from the emergence of a life cycle involving the formation of cell clusters. The opportunity for cells to interact within clusters provided them with an advantage over unicellular life forms. However, what kind of interactions may lead to the evolution of multicellular life cycles? Here, we combine evolutionary game theory with a model for the emergence of multicellular groups to investigate how cell... Читать дальше...

Human representation of multimodal distributions as clusters of samples

15.05.2019 00:00

Plos.org

by Jingwei Sun, Jian Li, Hang Zhang

Behavioral and neuroimaging evidence shows that human decisions are sensitive to the statistical regularities (mean, variance, skewness, etc.) of reward distributions. However, it is unclear what representations human observers form to approximate reward distributions, or probability distributions in general. When the possible values of a probability distribution are numerous, it is cognitively costly and perhaps unrealistic to maintain in mind the probability of each possible value. Читать дальше...

Spatial neuronal synchronization and the waveform of oscillations: Implications for EEG and MEG

15.05.2019 00:00

Plos.org

by Natalie Schaworonkow, Vadim V. Nikulin

Neuronal oscillations are ubiquitous in the human brain and are implicated in virtually all brain functions. Although they can be described by a prominent peak in the power spectrum, their waveform is not necessarily sinusoidal and shows rather complex morphology. Both frequency and temporal descriptions of such non-sinusoidal neuronal oscillations can be utilized. However, in non-invasive EEG/MEG recordings the waveform of oscillations often takes... Читать дальше...

Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution

15.05.2019 00:00

Plos.org

by Hannah Grace Roddie, Emma Louise Armitage, Jonathon Alexis Coates, Simon Andrew Johnston, Iwan Robert Evans

Islands of retroelements are major components of Drosophila centromeres

15.05.2019 00:00

Plos.org

by Ching-Ho Chang, Ankita Chavan, Jason Palladino, Xiaolu Wei, Nuno M. C. Martins, Bryce Santinello, Chin-Chi Chen, Jelena Erceg, Brian J. Beliveau, Chao-Ting Wu, Amanda M. Larracuente, Barbara G. Mellone

Новости России

Москва

Девочка 2019 года рождения выпала с девятого этажа в Москве на Ореховом бульваре

Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

15.05.2019 00:00

Plos.org

by John T. Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M. Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J. Matkovich, Kerry Kornfeld, Abhinav Diwan

Intact but empty forests? Patterns of hunting-induced mammal defaunation in the tropics

15.05.2019 00:00

Plos.org

by Ana Benítez-López, Luca Santini, Aafke M. Schipper, Michela Busana, Mark A. J. Huijbregts

BJ Penn talks about loss to Guida, says ‘the desire to compete is still there’

15.05.2019 00:00

Bloody Elbow

Despite suffering his seventh consecutive loss, BJ Penn wants to continue fighting.

Twenty-four hours with Nigel Farage: 'I won't be rolled over. This is the fightback I promised' - Telegraph.co.uk

15.05.2019 00:00

Sports - Google News (uk)

Twenty-four hours with Nigel Farage: 'I won't be rolled over. This is the fightback I promised' Telegraph.co.uk
Brexit: Theresa May to meet Corbyn as cabinet sets summer deadline for leaving EU The Independent
Nigel Farage’s Brexit Party are soaring in the polls. So why is he sounding so ratty? Telegraph.co.uk
Teaming up with Nigel Farage would trash the Conservative brand The Guardian
European elections 2019: Can you vote tactically in the European elections? Читать дальше...

Insider Inc. is hiring an HTML/Web Producer to join our Subscriptions team

15.05.2019 00:00

ThisIsinsider.com

Insider Inc. is hiring an HTML/Web Producer to join our Subscriptions team and build email and web assets that support our subscriber acquisition and retention efforts.

Police Investigate High School Student After Video of Racist Tirade Surfaces on the Internet

15.05.2019 00:00

TheRoot.com

Missouri’s Kickapoo High School can’t stay out the damn news.

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