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2019

Новости за 07.08.2019

Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span

Plos.org 

by Do Hee Kim, In Hye Jung, Dong Hee Kim, Seung Woo Park

Sirt1, a member of the sirtuin gene family, encodes the most conserved mammalian NAD+-dependent deacetylase enzyme responsible for removing acetyl groups from many proteins. The Sirt1 gene is known as a longevity gene whose knockout in mice leads to decreased lifespan relative to the wild type. This study aimed to explore phenotypic changes in zebrafish Sirt1-knockouts and to investigate the function of the Sirt1 gene. Targeted knockout... Читать дальше...

Gap analysis for drug development policy-making: An attempt to close the gap between policy and its implementation

Plos.org 

by Ria Christine Siagian, Dumilah Ayuningtyas

Introduction

Most drug development policies in developing countries are enacted without achieving the desired results. This study aims to determine the prioritization of drug development in Indonesia through the evidence-based policymaking process in order to close the distance between stated policy goals and the realization of planned goals.

Methods

A quantitative approach in the form of cross-sectional research using a structured survey... Читать дальше...



Новости России
Москва

Знаменитый ультрамарафонец Максим Егоров пробежит 42,2 км в поддержку фонда «Жизнь в Движении»


Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis

Plos.org 

by Jane L. Tarry-Adkins, Catherine E. Aiken, Susan E. Ozanne

Background

Metformin is increasingly offered as an acceptable and economic alternative to insulin for treatment of gestational diabetes mellitus (GDM) in many countries. However, the impact of maternal metformin treatment on the trajectory of fetal, infant, and childhood growth is unknown.

Methods and findings

PubMed, Ovid Embase, Medline, Web of Science, ClinicalTrials.gov, and the Cochrane database were systematically... Читать дальше...


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Андрей Рублёв

Теннисист Алькарас назвал Рублева одним из самых сильных игроков в туре






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Утренние рейсы задержаны в аэропорту Томска после коллапса в столицах