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Новости за 26.09.2019

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A comparison of machine learning algorithms for the surveillance of autism spectrum disorder

Plos.org 
En

by Scott H. Lee, Matthew J. Maenner, Charles M. Heilig

Objective

The Centers for Disease Control and Prevention (CDC) coordinates a labor-intensive process to measure the prevalence of autism spectrum disorder (ASD) among children in the United States. Random forests methods have shown promise in speeding up this process, but they lag behind human classification accuracy by about 5%. We explore whether more recently available document classification algorithms can close this gap.

Materials... Читать дальше...

NPHP proteins are binding partners of nucleoporins at the base of the primary cilium

Plos.org 
En

by T. Lynne Blasius, Daisuke Takao, Kristen J. Verhey

Cilia are microtubule-based organelles that protrude from the surface of eukaryotic cells to generate motility and to sense and respond to environmental cues. In order to carry out these functions, the complement of proteins in the cilium must be specific for the organelle. Regulation of protein entry into primary cilia has been shown to utilize mechanisms and components of nuclear gating, including nucleoporins of the nuclear pore complex (NPC). Читать дальше...



Overexpression of rice gene OsATG8b confers tolerance to nitrogen starvation and increases yield and nitrogen use efficiency (NUE) in Arabidopsis

Plos.org 
En

by Xiaoxi Zhen, Fan Xu, Wenzhong Zhang, Nan Li, Xin Li

Nitrogen (N) is an important element required for plant growth and development, which also affects plant yield and quality. Autophagy, a conserved pathway in eukaryotes, degrades and recycles cellular components, thus playing an important role in N remobilization. However, only a few autophagy genes related to N remobilization in rice (Oryza sativa) have been reported. Here, we identified a core autophagy gene in rice, OsATG8b, with increased... Читать дальше...

Glomerular hyperfiltration may be a novel risk factor of restrictive spirometry pattern: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2015

Plos.org 
En

by Hong Il Lim, Sang Jin Jun, Sung Woo Lee

Background and objectives

There have been limited studies regarding the association between glomerular hyperfiltration (GHF) and restrictive spirometry pattern (RSP) in Korean adults.

Methods

We used data of 23,189 adults from the Korea National Health and Nutritional Examination Survey 2009–2015 with a complete data set including spirometry, serum creatinine, and anthropometric measurements. Spirometry data included the forced expiratory... Читать дальше...

Optimal threshold of adherence to lipid lowering drugs in predicting acute coronary syndrome, stroke, or mortality: A cohort study

Plos.org 
En

by Arsène Zongo, Scot Simpson, Jeffrey A. Johnson, Dean T. Eurich

Objective

Thresholds defining medication adherence are rarely evidence-based. A threshold of 0.8 is typically presumed to achieve improved outcomes. We aimed to assess the optimal threshold of adherence to lipid-lowering drugs (LLD) in predicting cardiovascular-related (CV) outcomes in patients with hypertension.

Design

Cohort study of new users of LLDs.

Setting

Comprehensive healthcare administrative databases... Читать дальше...

Новости России
Москва

Искусство как память: в Театре Российской Армии прошел уникальный балетный марафон


Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience

Plos.org 
En

by Alessandra Mangia, Valeria Piazzolla, Anna Giannelli, Egidio Visaggi, Nicola Minerva, Vincenzo Palmieri, Immacolata Carraturo, Domenico Potenza, Nicola Napoli, Gianfranco Lauletta, Vincenzo Tagarielli, Rosanna Santoro, Ernesto Piccigallo, Sergio De Gioia, Angelo Chimenti, Giuseppe Cuccorese, Antonio Metrangolo, Michele Mazzola, Ernesto Agostinacchio, Giuseppe Mennea, Carlo Sabbà, Marina Cela, Massimiliano Copetti, Ruggiero Losappio

IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia

Plos.org 
En

by Clara Vásquez Velásquez, Graciela Russomando, Emilio E. Espínola, Zunilda Sanchez, Kota Mochizuki, Yelin Roca, Jimmy Revollo, Angelica Guzman, Benjamín Quiroga, Susana Rios Morgan, Roberto Vargas Ortiz, Alberto Zambrana Ortega, Eida Espinoza, Juan Eiki Nishizawa, Mohamed Gomaa Kamel, Mihoko Kikuchi, Shusaku Mizukami, Kesara Na-Bangchang, Nguyen Tien Huy, Kenji Hirayama

Читать дальше...

Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening: a multicountry patient-level meta-analysis of 141,220 screened individuals

Plos.org 
En

by Nicole Lowres, Jake Olivier, Tze-Fan Chao, Shih-Ann Chen, Yi Chen, Axel Diederichsen, David A. Fitzmaurice, Juan Jose Gomez-Doblas, Joseph Harbison, Jeff S. Healey, F. D. Richard Hobbs, Femke Kaasenbrood, William Keen, Vivian W. Lee, Jes S. Lindholt, Gregory Y. H. Lip, Georges H. Mairesse, Jonathan Mant, Julie W. Martin, Enrique Martín-Rioboó, David D. McManus, Javier Muñiz, Thomas Münzel, Juliet Nakamya, Lis Neubeck, Jessica J. Orchard, Luis Ángel Pérula de Torres, Marco Proietti, F. Russell Quinn, Andrea K. Читать дальше...


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