Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies
by Shuang Song, Wei Jiang, Lin Hou, Hongyu Zhao
Genetic risk prediction is an important problem in human genetics, and accurate prediction can facilitate disease prevention and treatment. Calculating polygenic risk score (PRS) has become widely used due to its simplicity and effectiveness, where only summary statistics from genome-wide association studies are needed in the standard method. Recently, several methods have been proposed to improve standard PRS by utilizing external information... Читать дальше...