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Doxycycline induces Hok toxin killing in host E. coli

Plos.org 
En

by Chinwe Uzoma Chukwudi, Liam Good

The antibacterial efficacy of the tetracycline antibiotics has been greatly reduced by the development of resistance, hence a decline in their clinical use. The hok/sok locus is a type I toxin/antitoxin plasmid stability element, often associated with multi-drug resistance plasmids, especially ESBL-encoding plasmids. It enhances host cell survivability and pathogenicity in stressful growth conditions, and increases bacterial tolerance to β-lactam antibiotics. Читать дальше...

Effect of methotrexate use on the development of type 2 diabetes in rheumatoid arthritis patients: A systematic review and meta-analysis

Plos.org 
En

by Leena R. Baghdadi

Background

The high risk of cardiovascular disease is well recognized in rheumatoid arthritis. Type 2 diabetes also attributes to this increase in risk. Rheumatoid arthritis is a chronic inflammatory condition, which aggravates insulin resistance, placing the patients at a higher risk of type 2 diabetes and subsequent cardiovascular outcomes. Methotrexate treatment, as a gold standard anti-inflammatory drug in the treatment of rheumatoid arthritis has shown beneficial effects on cardiovascular health. Читать дальше...

Feasibility and technique of endovenous laser ablation (EVLA) of recurrent varicose veins deriving from the sapheno-femoral junction—A case series of 35 consecutive procedures

Plos.org 
En

by Lars Müller, Jens Alm

Aim

To assess the feasibility and technical success of endovenous laser ablation (EVLA) of recurrent varicose veins arising from the former sapheno-femoral junction (SFJ).

Methods

We retrospectively analyzed all EVLA procedures treated in our institution by one surgeon between March 2019 and April 2020 and selected all consecutive cases with SFJ recurrence occuring after surgical high ligation and stripping or endovenous thermal ablation for incompetence... Читать дальше...



Mobility restrictions for the control of epidemics: When do they work?

Plos.org 
En

by Baltazar Espinoza, Carlos Castillo-Chavez, Charles Perrings

Background

Mobility restrictions—trade and travel bans, border closures and, in extreme cases, area quarantines or cordons sanitaires—are among the most widely used measures to control infectious diseases. Restrictions of this kind were important in the response to epidemics of SARS (2003), H1N1 influenza (2009), Ebola (2014) and, currently in the containment of the ongoing COVID-19 pandemic. However, they do not always work as expected. Читать дальше...

Validation of the scale for assessing the psychological vulnerability and its association with health of intimate partner violence victims in Chinese young adult population

Plos.org 
En

by Anna W. M. Choi

The Women’s Experience with Battering (WEB) scale is a self-report instrument that uses a 10-item Likert-type scale to measure IPV victims’ cognitive and affective experience of battering. This study aimed to validate the Chinese version of the WEB scale using gender-neutral questions, Experience of Battering Scale (Chinese) (EBS-C), to assess the psychological vulnerability of victims of intimate partner violence (IPV). The study adopted a range of methods, including translation and back translation... Читать дальше...

The passage of time during the UK Covid-19 lockdown

Plos.org 
En

by Ruth S. Ogden

In March 2020, in response to the Covid-19 pandemic, the UK Government imposed social and physical distancing measures on the population. These lockdown measures caused significant changes to all aspects of daily life. The current study examined how the passage of time was distorted during the lockdown period. Using an online questionnaire, day and week passage of time judgments were collected. In addition, measures of affect, task load and satisfaction with current levels of social interaction were taken. Читать дальше...

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Москва

ВЦ «Раздолье» приглашает заказчиков на ценовую кухню IT-проектов


Aquatic macrophytes and macroinvertebrate predators affect densities of snail hosts and local production of schistosome cercariae that cause human schistosomiasis

Plos.org 
En

by Christopher J. E. Haggerty, Sidy Bakhoum, David J. Civitello, Giulio A. De Leo, Nicholas Jouanard, Raphael A. Ndione, Justin V. Remais, Gilles Riveau, Simon Senghor, Susanne H. Sokolow, Souleymane Sow, Caitlin Wolfe, Chelsea L. Wood, Isabel Jones, Andrew J. Chamberlin, Jason R. Rohr

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Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

Plos.org 
En

by Marc P. Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Stefan J. Frohberger, Alexandra Ehrens, Martina Fendler, Dominique Struever, Edward Mitre, Nathaly Vallarino-Lhermitte, Suzanne Gokool, Sara Lustigman, Manfred Schneider, Simon Townson, Achim Hoerauf, Ivan Scandale

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