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Новости за 07.07.2020

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Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada

Plos.org 
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by Andrea A. Jones, Kristina M. Gicas, Sam Seyedin, Taylor S. Willi, Olga Leonova, Fidel Vila-Rodriguez, Ric M. Procyshyn, Geoffrey N. Smith, Toby A. Schmitt, A. Talia Vertinsky, Tari Buchanan, Alex Rauscher, Donna J. Lang, G. William MacEwan, Viviane D. Lima, Julio S. G. Montaner, William J. Panenka, Alasdair M. Barr, Allen E. Thornton, William G. Honer

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Electrostatic and bending energies predict staggering and splaying in nonmuscle myosin II minifilaments

Plos.org 
En

by Tom L. Kaufmann, Ulrich S. Schwarz

Recent experiments with super-resolution live cell microscopy revealed that nonmuscle myosin II minifilaments are much more dynamic than formerly appreciated, often showing plastic processes such as splitting, concatenation and stacking. Here we combine sequence information, electrostatics and elasticity theory to demonstrate that the parallel staggers at 14.3, 43.2 and 72 nm have a strong tendency to splay their heads away from the minifilament, thus... Читать дальше...

Winter is coming: Pathogen emergence in seasonal environments

Plos.org 
En

by Philippe Carmona, Sylvain Gandon

Many infectious diseases exhibit seasonal dynamics driven by periodic fluctuations of the environment. Predicting the risk of pathogen emergence at different points in time is key for the development of effective public health strategies. Here we study the impact of seasonality on the probability of emergence of directly transmitted pathogens under different epidemiological scenarios. We show that when the period of the fluctuation is large relative to the duration of the infection... Читать дальше...



Is mammography screening beneficial: An individual-based stochastic model for breast cancer incidence and mortality

Plos.org 
En

by Thuy T. T. Le, Frederick R. Adler

The benefits of mammography screening have been controversial, with conflicting findings from various studies. We hypothesize that unmeasured heterogeneity in tumor aggressiveness underlies these conflicting results. Based on published data from the Canadian National Breast Screening Study (CNBSS), we develop and parameterize an individual-based mechanistic model for breast cancer incidence and mortality that tracks five stages of breast cancer progression... Читать дальше...

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