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The organization, weaknesses, and challenges of the control of thalidomide in Brazil: A review

Plos.org 
En

by Soraya Machado de Jesus, Rafael Santos Santana, Silvana Nair Leite

The drug thalidomide has resurged in the world market under restrictive conditions for marketing and use. In Brazil, there are still cases of pregnant women using thalidomide even after the implementation of laws that regulate the control of use (Law No. 10.651/2003 and Collegiate Board Resolution No. 11/2011). The objective of this study was to discuss the control of thalidomide use in Brazil, based on a scoping review of the scientific literature... Читать дальше...

SARS-CoV-2 infection in China—Before the pandemic

Plos.org 
En

by Huiying Liang, Lingling Zheng, Huimin Xia, Jinling Tang

In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in China and impact of interventional measures, and some lessons learned. We concluded that the epidemic is containable with traditional nonpharmacological interventions... Читать дальше...

A gender-sensitised weight-loss and healthy living program for men with overweight and obesity in Australian Football League settings (Aussie-FIT): A pilot randomised controlled trial

Plos.org 
En

by Dominika Kwasnicka, Nikos Ntoumanis, Kate Hunt, Cindy M. Gray, Robert U. Newton, Daniel F. Gucciardi, Cecilie Thøgersen-Ntoumani, Jenny L. Olson, Joanne McVeigh, Deborah A. Kerr, Sally Wyke, Philip J. Morgan, Suzanne Robinson, Marshall Makate, Eleanor Quested

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Temporal variations in the distribution of self-harm episodes and methods across the Australian asylum seeker population: An observational study

Plos.org 
En

by Kyli Hedrick, Gregory Armstrong, Guy Coffey, Rohan Borschmann

Background

Temporal patterns in the frequency and characteristics of self-harm episodes across the Australian asylum seeker population may have implications for self-harm prevention and public health policy. The aim of this study was to examine how the distribution of self-harm episodes and method(s) of self-harm used across the Australian asylum seeker population vary according to the 24-hour cycle, day, and month, and to establish a basis for further research. Читать дальше...



Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph

Plos.org 
En

by Melissa J. Hubisz, Amy L. Williams, Adam Siepel

The sequencing of Neanderthal and Denisovan genomes has yielded many new insights about interbreeding events between extinct hominins and the ancestors of modern humans. While much attention has been paid to the relatively recent gene flow from Neanderthals and Denisovans into modern humans, other instances of introgression leave more subtle genomic evidence and have received less attention. Here, we present a major extension of the ARGweaver algorithm... Читать дальше...

Long noncoding RNA functionality in imprinted domain regulation

Plos.org 
En

by William A. MacDonald, Mellissa R. W. Mann

Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription to predominantly one parental allele. Since the discovery of the first long noncoding RNA (lncRNA), which notably was an imprinted lncRNA, a body of knowledge has demonstrated pivotal roles for imprinted lncRNAs in regulating parental-specific expression of neighboring imprinted genes. In this Review, we will discuss the multiple functionalities attributed... Читать дальше...

Effect of magnitude and variability of energy of activation in multisite ultrasensitive biochemical processes

Plos.org 
En

by Leonila Lagunes, Lee Bardwell, German A. Enciso

Protein activity is often regulated by ligand binding or by post-translational modifications such as phosphorylation. Moreover, proteins that are regulated in this way often contain multiple ligand binding sites or modification sites, which can operate to create an ultrasensitive dose response. Here, we consider the contribution of the individual modification/binding sites to the activation process, and how their individual values affect... Читать дальше...

2020 PGA Championship Live Stream, Tee Times, Live Leaderboard, TV Channel, Start Time - MSN Money

Top Stories (us) - Google News (com) 
En

  1. 2020 PGA Championship Live Stream, Tee Times, Live Leaderboard, TV Channel, Start Time  MSN Money
  2. Tiger Woods score, results, highlights from up-and-down Round 1 at PGA Championship  Sporting News
  3. PGA Championship: Here’s how to buy Tiger Woods’ stars-and-stripes-themed face covering  AL.com
  4. The Latest: 2015 winner Jason Day takes early lead at PGA  MSN Money
  5. Tiger's terrific shot sets up birdie to open his day at the PGA Championship  TSN
  6. View Full... Читать дальше...

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How do I apply for a £5,000 Green Homes Grant voucher and do I qualify for one?

TheSun.co.uk 
En

THE chancellor has announced homeowners will be given £5,000 in energy saving vouchers to help them insulate their homes. The new policy is part of Rishi Sunak’s plans to create more than 100,000 green jobs and kickstart the economy after the coronavirus lockdown. This week, the Treasury announced more details about the scheme – including […]


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