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2020

Новости за 15.08.2020

A multiphase program for malaria elimination in southern Mozambique (the Magude project): A before-after study

Plos.org 

by Beatriz Galatas, Francisco Saúte, Helena Martí-Soler, Caterina Guinovart, Lidia Nhamussua, Wilson Simone, Humberto Munguambe, Camilo Hamido, Júlia Montañà, Olinda Muguande, Francois Maartens, Fabião Luis, Krijn Paaijmans, Alfredo Mayor, Quique Bassat, Clara Menéndez, Eusebio Macete, Regina Rabinovich, Pedro L. Alonso, Baltazar Candrinho, Pedro Aide

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Identification of intraductal carcinoma of the prostate on tissue specimens using Raman micro-spectroscopy: A diagnostic accuracy case–control study with multicohort validation

Plos.org 

by Andrée-Anne Grosset, Frédérick Dallaire, Tien Nguyen, Mirela Birlea, Jahg Wong, François Daoust, Noémi Roy, André Kougioumoutzakis, Feryel Azzi, Kelly Aubertin, Samuel Kadoury, Mathieu Latour, Roula Albadine, Susan Prendeville, Paul Boutros, Michael Fraser, Rob G. Bristow, Theodorus van der Kwast, Michèle Orain, Hervé Brisson, Nazim Benzerdjeb, Hélène Hovington, Alain Bergeron, Yves Fradet, Bernard Têtu, Fred Saad, Frédéric Leblond, Dominique Trudel

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Information transmission from NFkB signaling dynamics to gene expression

Plos.org 

by Alok Maity, Roy Wollman

The dynamic signal encoding paradigm suggests that information flows from the extracellular environment into specific signaling patterns (encoding) that are then read by downstream effectors to control cellular behavior. Previous work empirically quantified the information content of dynamic signaling patterns. However, whether this information can be faithfully transmitted to the gene expression level is unclear. Here we used NFkB signaling as a model to understand... Читать дальше...

Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits

Plos.org 

by Craig A. Glastonbury, Sara L. Pulit, Julius Honecker, Jenny C. Censin, Samantha Laber, Hanieh Yaghootkar, Nilufer Rahmioglu, Emilie Pastel, Katerina Kos, Andrew Pitt, Michelle Hudson, Christopher Nellåker, Nicola L. Beer, Hans Hauner, Christian M. Becker, Krina T. Zondervan, Timothy M. Frayling, Melina Claussnitzer, Cecilia M. Lindgren

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Inferring the ancestry of parents and grandparents from genetic data

Plos.org 

by Jingwen Pei, Yiming Zhang, Rasmus Nielsen, Yufeng Wu

Inference of admixture proportions is a classical statistical problem in population genetics. Standard methods implicitly assume that both parents of an individual have the same admixture fraction. However, this is rarely the case in real data. In this paper we show that the distribution of admixture tract lengths in a genome contains information about the admixture proportions of the ancestors of an individual. We develop a Hidden Markov... Читать дальше...


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