An update on natural bioactive compounds
(Bentham Science Publishers) This new volume of the series highlights a new set of natural products which are currently under clinical trial.
(Bentham Science Publishers) This new volume of the series highlights a new set of natural products which are currently under clinical trial.
Scientists developed a methodology that uses next-generation sequencing technology for fast and efficient screening of genetic diversity of fish eye parasites.
In physics, it is essential to be able to show a theoretical assumption in actual, physical experiments. For more than a hundred years, physicists have been aware of the link between the concepts of disorder in a system, and information obtained by measurement. However, a clean experimental assessment of this link in common monitored systems, that is systems which are continuously measured over time, was missing so far.
Ancient hunters stayed in the coldest part of Northern Europe rather than migrating to escape freezing winter conditions, archaeologists have found.
Russian researchers have discovered what makes vanadium dioxide films conduct electricity. Published in Physical Review B, their findings will enable thermal imaging devices with a sensitivity and reaction rate superior to those of the currently existing analogues.
Micropollutants contaminate the water worldwide. Among them are steroid hormones that cannot be eliminated efficiently by conventional processes. Researchers of Karlsruhe Institute of Technology (KIT) have developed an innovative filtration system that combines a polymer membrane with activated carbon. The improved method is reported in Water Research (DOI:10.1016/j.watres.2020.116249).
An international research with the involvement of the Universitat Autònoma de Barcelona (UAB), published in Science, has developed a new dynamic mathematical model which represents a change in paradigm in predicting the probability of heat-related mortality in small species. The study, which has validated field experiments conducted with the Drosophila subobscura fly, concludes that the current standard model subestimates species' vulnerability to climate warming and extreme temperatures.
Zaire ebolavirus is among the deadliest of all known Ebola viruses for humans and is most likely transmitted by various species of bats. Models recently developed by scientists of the Senckenberg Nature Research Society and the Goethe University in Frankfurt show where these species may thrive in Africa. The results of the study, published in the journal "Scientific Reports", suggest a wider range of distribution for the bat and fruit bat species than previously assumed.
Older people and people with underlying medical conditions are at particular risk of severe COVID-19. A group of researchers from Charité -- Universitätsmedizin Berlin have discovered one possible reason for this vulnerability. While these risk groups produce greater quantities of an important type of immune cell known as 'T-helper cells', their T-helper cells show impaired function. This 'molecular brake' on the immune system could serve as a potential new treatment target in patients with severe COVID-19.
Scientists from King's College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated. The breakthrough will have important implications for treating patients who suffer from inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis.
In this research article, for the first time, the researchers have introduced a quantitative index; asymptomatic growth, to indicate whether COVID-19 community spread is under control and if economic activities can be resumed.
"Promising" fungal leather that looks and feels like traditional leather could be eco-friendlier and cheaper than animal and plastic versions.
Spearheaded by Wistar scientists, top worldwide HIV researchers from the BEAT-HIV Martin Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy (BEAT-HIV Collaboratory) compiled the first comprehensive set of recommendations on how to best measure the size of persistent HIV reservoirs during cure-directed clinical studies.
Pioneering scientists at the Francis Crick Institute, Great Ormond Street Hospital (GOSH) and UCL Great Ormond Street Institute of Child Health (ICH) have grown human intestinal grafts using stem cells from patient tissue that could one day lead to personalised transplants for children with intestinal failure, according to a study published in Nature Medicine.
A recent study by a team based at the University of Bologna, published in the Journal of Archaeological Science, has shed new light on the Minoan system of fractions, one of the outstanding enigmas tied to the ancient writing of numbers.
During domestication, dogs most probably have been selected for increased tractability. If so, then considerable differences should be found between domestic dogs and their closest wild relatives, wolves, in this trait. To reveal if such a difference exists, researchers at the Family Dog Project, Eötvös Loránd University assessed the development of tractability in hand-raised wolves and similarly raised, 3-24-week-old dogs. They found that despite intensive socialization, wolves remained less tractable than dogs.
Australian rodents skulls all correspond to one simple, size-dependent shape that is more than ten million years old but it turns out this lack of change is the secret behind their survivor reputation.
An Australian-led study provides new insight into the behaviour of rotating superfluids, including the emergence of a 'top hat' shaped super-vortex phenomenon. Fundamental understanding of the behaviour of vortices in superfluids (a 'zero viscosity' quantum material in which electrical current can flow without resistance) is vital to FLEET's search for ultra-energy efficient electronics based on superfluid transistors.
An international team of investigators led by Memorial Sloan Kettering's Robert Motzer has identified biological attributes of kidney cancer tumors that correlate with better responses to immunotherapies and targeted therapies.
Tohoku University Professor Taiichi Otsuji has led a team of international researchers in successfully demonstrating a room-temperature coherent amplification of terahertz (THz) radiation in graphene, electrically driven by a dry cell battery.
(Bentham Science Publishers) The first volume of the series 'Frontiers in Enzyme Inhibition' presents various aspects of utilizing enzyme inhibitors for environmental and medicine purpose.
(The Korea Advanced Institute of Science and Technology (KAIST)) On September 9, the Global Strategy Institute at KAIST will delve into innovative future strategies for the medical and bio-engineering sectors that have been disrupted by COVID-19. The forum will live stream via YouTube, KTV, and Naver TV from 9:00 am Korean time.
Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins. When assembled correctly, these complexes play a crucial role in the development of normal tissues, and when broken, they can lead to the development of cancer. These complexes are commonly disrupted by mutations in the genes that encode them - but how this leads to cancer is poorly understood.
If silence is golden, speech is silver - and singing the worst.Singing doesn't need to be silenced, however, but at the moment the wisest thing is to sing with social distancing in place. The advice comes from aerosol researchers at Lund University in Sweden. They have studied the amount of particles we actually emit when we sing - and by extension - if we contribute to the increased spread of Covid-19 by singing.
A new application of the CRISPR/Cas molecular scissors promises progress in crop cultivation. At Karlsruhe Institute of Technology (KIT), researchers have succeeded in modifying the sequence of genes on a chromosome using CRISPR/Cas. For the first time, they took a known chromosome modification in the thale cress model plant and demonstrated how inversions of the gene sequence can be undone and inheritance can thus be controlled. The results are published in Nature Communications (DOI: 10.1038/s41467-020-18277-z).