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Новости за 16.09.2020

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Construction and analysis of a competing endogenous RNA network to reveal potential prognostic biomarkers for Oral Floor Squamous Cell Carcinoma

Plos.org 
En

by Wenjing Zhang, Shuai Xu, Laner Shi, Zhangzhi Zhu, Xinying Xie

Background

Patients diagnosed with Oral Floor Squamous Cell Carcinoma (OFSCC) face considerable challenges in physiology and psychology. This study explored prognostic signatures to predict prognosis in OFSCC through a detailed transcriptomic analysis.

Method

We built an interactive competing endogenous RNA (ceRNA) network that included lncRNAs, miRNAs and mRNAs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and... Читать дальше...

Go big or go home: A model-based assessment of general strategies to slow the spread of forest pests via infested firewood

Plos.org 
En

by Peter C. Jentsch, Chris T. Bauch, Denys Yemshanov, Madhur Anand

Invasive pests, such as emerald ash borer or Asian longhorn beetle, have been responsible for unprecedented ecological and economic damage in eastern North America. These and other wood-boring invasive insects can spread to new areas through human transport of untreated firewood. Behaviour, such as transport of firewood, is affected not only by immediate material benefits and costs, but also by social forces. Potential approaches... Читать дальше...

Modeling sickness absence data: A scoping review

Plos.org 
En

by Tom Duchemin, Mounia N. Hocine

The identification of sick leave determinants could positively influence decision making to improve worker quality of life and to reduce consequently costs for society. Sick leave is a research topic of interest in economics, psychology, health and social behaviour. The question of choosing an appropriate statistical tool to analyse sick leave data can be challenging. In fact, sick leave data have a complex structure, characterized by two dimensions: frequency and duration... Читать дальше...

No safety net in the face of climate change: The case of pastoralists in Kunene Region, Namibia

Plos.org 
En

by Emilia N. Inman, Richard J. Hobbs, Zivanai Tsvuura

Over the past decade, pastoralists in Kunene Region, Namibia, have endured recurrent drought and flood events that have culminated in the loss of their primary form of livelihood–pastoralism. Most pastoralists are finding it difficult to sustain their livelihoods, and their communities have fallen into extreme poverty. Ecosystem-based Adaptation (EbA) approaches are increasingly acknowledged as having the potential to enhance the adaptive capacity of vulnerable communities. Читать дальше...



To defer or not to defer? A German longitudinal multicentric assessment of clinical practice in urology during the COVID-19 pandemic

Plos.org 
En

by Nina N. Harke, Jan P. Radtke, Boris A. Hadaschik, Christian Bach, Frank P. Berger, Andreas Blana, Hendrik Borgmann, Florian A. Distler, Sebastian Edeling, Tobias Egner, Christina L. Engels, Mahmoud Farzat, Alexander Haese, Rainer Hein, Markus A. Kuczyk, Andreas Manseck, Rudolf Moritz, Michael Musch, Inga Peters, Sasa Pokupic, Bernardo Rocco, Andreas Schneider, André Schumann, Christian Schwentner, Chiara M. Sighinolfi, Stephan Buse, Jens-Uwe Stolzenburg, Michael C. Truß, Michael Waldner, Christian Wülfing, Volker Zimmermanns, Jörn H. Читать дальше...

A novel approach to predicting exceptional growth in research

Plos.org 
En

by Richard Klavans, Kevin W. Boyack, Dewey A. Murdick

The prediction of exceptional or surprising growth in research is an issue with deep roots and few practical solutions. In this study, we develop and validate a novel approach to forecasting growth in highly specific research communities. Each research community is represented by a cluster of papers. Multiple indicators were tested, and a composite indicator was created that predicts which research communities will experience exceptional growth over the next three years. Читать дальше...

Search, reuse and sharing of research data in materials science and engineering—A qualitative interview study

Plos.org 
En

by Bettina Suhr, Johanna Dungl, Alexander Stocker

Open research data practices are a relatively new, thus still evolving part of scientific work, and their usage varies strongly within different scientific domains. In the literature, the investigation of open research data practices covers the whole range of big empirical studies covering multiple scientific domains to smaller, in depth studies analysing a single field of research. Despite the richness of literature on this topic, there is... Читать дальше...

Endocrine profiling of reproductive status and evidence of pseudopregnancy in the Pacific walrus (Odobenus rosmarus divergens)

Plos.org 
En

by Jenell T. Larsen Tempel, Shannon Atkinson

Endocrine profiling is an increasingly utilized tool for detecting pregnancies in wild populations of mammals. Given the difficulty in calculating reproductive rates of Pacific walruses (Odobenus rosmarus divergens) the use of endocrine techniques for determining pregnancy rates could be particularly useful for management of the population. The goals of this study were to 1) determine if progesterone and total estrogen concentrations in ovarian... Читать дальше...

Evaluating approaches to designing effective Co-Created hand-hygiene interventions for children in India, Sierra Leone and the UK

Plos.org 
En

by Sapphire Crosby, Sarah Younie, Iain Williamson, Katie Laird

Effective and culturally appropriate hand-hygiene education is essential to promote health-related practices to control and prevent diseases such as Diarrhoea, Ebola and COVID-19. In this paper we outline and evaluate the Co-Creation processes underpinning a handwashing intervention for young children (A Germ’s Journey) developed and delivered in India, Sierra Leone and the UK, and consider the implications surrounding Imperialist/Colonial... Читать дальше...

Новости России
Москва

Журналист Карпов: Федора Смолова спровоцировали на драку, а потом шантажировали


The propagation of economic impacts through supply chains: The case of a mega-city lockdown to prevent the spread of COVID-19

Plos.org 
En

by Hiroyasu Inoue, Yasuyuki Todo

This study quantifies the economic effect of a possible lockdown of Tokyo to prevent the spread of COVID-19. The negative effect of such a lockdown may propagate to other regions through supply chains because of supply and demand shortages. Applying an agent-based model to the actual supply chains of nearly 1.6 million firms in Japan, we simulate what would happen to production activities outside Tokyo if production activities that are not essential to citizens’... Читать дальше...

Financing innovation and enterprises’ efficiency of technological innovation in the internet industry: Evidence from China

Plos.org 
En

by Zhefan Piao, Yueqin Lin

This study empirically examined the impact of financing innovation on technological innovation efficiency of select internet companies, that were affiliated with China between 2008 and 2017. Analysis was based on their patent and annual report data and used multiple input-output SFA model, system GMM, and panel fixed-effect model. The results are as follows. (1) There is significant variation in overall technological innovation efficiency of listed companies in the internet industry... Читать дальше...

Radiocesium concentrations in mushrooms collected in Kawauchi Village five to eight years after the Fukushima Daiichi Nuclear Power Plant accident

Plos.org 
En

by Limeng Cui, Makiko Orita, Yasuyuki Taira, Noboru Takamura

Following the Fukushima Daiichi Nuclear Power Plant accident in March 2011, radionuclides such as iodine-131, cesium-134 and cesium-137 were released into environment. In this study, we collected wild mushrooms from the Kawauchi Village of Fukushima Prefecture, located less than 30 km southwest of the Fukushima nuclear power plant, to evaluate their radiocesium (134Cs+137Cs) concentrations and the risk of internal radiation exposure in local residents. Читать дальше...

ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

Plos.org 
En

by Stephanie Devignot, Thilo Kromer, Ali Mirazimi, Friedemann Weber

Crimean-Congo Hemorrhagic Fever virus (CCHFV; family Nairoviridae) is an extremely pathogenic member of the Bunyavirales order. Previous studies have shown that the N-terminal domain of the CCHFV polymerase (L) contains an ovarian tumor-type protease (OTU) domain with the capability to remove both ubiquitin and ISG15 molecules from proteins. The approximately 200 amino acids-long OTU domain, if ectopically expressed, can... Читать дальше...


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