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Сентябрь
2020

Новости за 26.09.2020



A first nation-wide assessment of soil-transmitted helminthiasis in Fijian primary schools, and factors associated with the infection, using a lymphatic filariasis transmission assessment survey as surveillance platform

Plos.org 

by Sung Hye Kim, J. Russell Stothard, Milika Rinamalo, Meleresita Rainima-Qaniuci, Nemani Talemaitoga, Mike Kama, Eric Rafai, Seoyun Jang, Ji Young Kim, Yoo Min Oh, Eun-Min Kim, Sung-Tae Hong, John H. Lowry, Jaco J. Verweij, Louise A. Kelly-Hope, Min-Ho Choi

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Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models

Plos.org 

by Grace Zdesenko, Francisca Mutapi

Schistosomiasis control is heavily reliant on the drug praziquantel (PZQ), which is used as preventive chemotherapy as part of national helminth control strategies. Given the heavy reliance on PZQ for mass drug administration, there has been considerable research on the potential of parasites developing resistance to the drug, resulting in decreased drug efficacy. However, there have been comparatively fewer studies of other factors that can potentially alter PZQ efficacy. Читать дальше...

State-level prescription drug monitoring program mandates and adolescent injection drug use in the United States, 1995–2017: A difference-in-differences analysis

Plos.org 

by Joel J. Earlywine, Scott E. Hadland, Julia Raifman

Background

Prescription opioid misuse is an ongoing crisis and a risk factor for injection drug use (IDU). Few studies have evaluated strategies for preventing opioid or IDU initiation among adolescents. We evaluated changes in the proportion of adolescents reporting IDU before and after prescription drug monitoring program (PDMP) mandates were implemented in 18 states compared to 29 states without such mandates.

Methods and findings... Читать дальше...

Новости России
Москва

Святой доктор или Пельтцер? Кто исполняет желания на Введенском кладбище


Short-term depression and long-term plasticity together tune sensitive range of synaptic plasticity

Plos.org 

by Nicolas Deperrois, Michael Graupner

Synaptic efficacy is subjected to activity-dependent changes on short- and long time scales. While short-term changes decay over minutes, long-term modifications last from hours up to a life-time and are thought to constitute the basis of learning and memory. Both plasticity mechanisms have been studied extensively but how their interaction shapes synaptic dynamics is little known. To investigate how both short- and long-term plasticity together control... Читать дальше...


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Уимблдон

Эффектно и хладнокровно: Рахимова вышибла с Уимблдона прошлогоднюю финалистку, Рублёв и Хачанов вымучили победы






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Фигуристка Евгения Тарасова ждет ребенка

В Москве прохожие спасли пытавшегося покончить с собой мужчину в метр

Путин из-за холодного лета пошутил о скором приближении зимы