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Новости за 29.09.2020

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Facing obesity in pain rehabilitation clinics: Profiles of physical activity in patients with chronic pain and obesity—A study from the Swedish Quality Registry for Pain Rehabilitation (SQRP)

Plos.org 
En

by Huan-Ji Dong, Britt Larsson, Marcelo Rivano Fischer, Björn Gerdle

Background

The obesity epidemic has influenced pain rehabilitation clinics. To date, little is known about baseline level of physical activity (PA) in patients referred to pain rehabilitation clinics. We aimed to investigate the PA levels of patients referred to pain rehabilitation clinics and to evaluate the effect of excess weight on PA level.

Methods and findings

Data were obtained from the Swedish Quality Registry... Читать дальше...



Modelling bioactivities of combinations of whole extracts of edibles with a simplified theoretical framework reveals the statistical role of molecular diversity and system complexity in their mode of action and their nearly certain safety

Plos.org 
En

by Pascal Mayer

Network pharmacology and polypharmacology are emerging as novel drug discovery paradigms. The many discovery, safety and regulatory issues they raise may become tractable with polypharmacological combinations of natural compounds found in whole extracts of edible and mixes thereof. The primary goal of this work is to get general insights underlying the innocuity and the emergence of beneficial and toxic activities of combinations of many compounds in general and of edibles in particular. Читать дальше...

Comparison of efficacy and safety of laparoscopic excision and open operation in children with choledochal cysts: A systematic review and update meta-analysis

Plos.org 
En

by Rui Sun, Na Zhao, Ke Zhao, Zhe Su, Yifan Zhang, Mei Diao, Long Li

Objective

The outcomes of children with Choledochal cyst who undergo laparoscopic cyst excision and Roux-en-Y hepaticojejunostomy versus open cyst excision and Roux-en-Y hepaticojejunostomy have not been adequately compared. We conducted a systematic review and meta-analysis to gain further insight into the efficacy and safety of laparoscopic excision in children with choledochal cysts.

Methods

A systematic search of PubMed... Читать дальше...

Новости России

Efficacy, tolerability, and safety of an innovative medical device for improving oral accessibility during oral examination in special-needs patients: A multicentric clinical trial

Plos.org 
En

by Mathieu Mogenot, Laurence Hein-Halbgewachs, Christophe Goetz, Nadia Ouamara, Dominique Droz-Desprez, Catherine Strazielle, Sylvie Albecker, Brigitte Mengus, Marion Strub, Marie-Cécile Manière, Pascal Richardin, Stéphane Wang, Giuseppa Piga, Amélie Dalstein, Daniel Anastasio

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Interaction between influenza A virus nucleoprotein and PB2 cap-binding domain is mediated by RNA

Plos.org 
En

by Wun-Chung Szeto, Ho-Pan Hsia, Yun-Sang Tang, Pang-Chui Shaw

Influenza A virus controls replication and transcription of its genome through the tight regulation of interaction between the ribonucleoprotein (RNP) complex subunits. The helical scaffold of RNP is maintained by nucleoprotein (NP). Previous studies have revealed that NP interacts with both PB2 N-terminal and C-terminal regions, with both regions sharing similar affinity to NP as revealed in co-immunoprecipitation assay. Our... Читать дальше...


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