To the Editor Dr Mikolajczyk and colleagues presented a JAMA Clinical Challenge of a 55-year-old man with a single-phase computed tomography (CT) scan demonstrating multiple liver lesions suspicious for malignancy, with the remaining liver morphologically normal. An elevated α-fetoprotein level was present. A triple-phase CT scan was obtained to evaluate the small bowel, and a pancreatic tail mass was discovered. The authors stated that the next step would be to perform endoscopic ultrasound-guided fine-needle aspiration of the pancreatic mass.