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2021 Acura TLX Long-Term Update | Child and infant car seat test

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Filed under: Long-Term Garage,Sedan,Driveway Tests

Continue reading 2021 Acura TLX Long-Term Update | Child and infant car seat test

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Shooting yourself in the foot: How immune cells induce antibiotic tolerance in microbial pathogens

Plos.org 

by Jenna E. Beam, Sarah E. Rowe, Brian P. Conlon

Antibiotic treatment failure of infection is common and frequently occurs in the absence of genetically encoded antibiotic resistance mechanisms. In such scenarios, the ability of bacteria to enter a phenotypic state that renders them tolerant to the killing activity of multiple antibiotic classes is thought to contribute to antibiotic failure. Phagocytic cells, which specialize in engulfing and destroying invading pathogens, may paradoxically... Читать дальше...

Aiming for a bull’s-eye: Targeting antifungals to fungi with dectin-decorated liposomes

Plos.org 

by Richard B. Meagher, Zachary A. Lewis, Suresh Ambati, Xiaorong Lin

Globally, there are several million individuals with life-threatening invasive fungal diseases such as candidiasis, aspergillosis, cryptococcosis, Pneumocystis pneumonia (PCP), and mucormycosis. The mortality rate for these diseases generally exceeds 40%. Annual medical costs to treat these invasive fungal diseases in the United States exceed several billion dollars. In addition to AIDS patients, the risks of invasive mycoses... Читать дальше...

Antibody-independent functions of B cells during viral infections

Plos.org 

by Vinit Upasani, Izabela Rodenhuis-Zybert, Tineke Cantaert

The humoral immune response and antibody-mediated functions of B cells during viral infections are well described. However, we have limited understanding of antibody-independent B cell functions, such as cytokine production and antigen presentation, in acute and chronic viral infections and their role in protection and/or immunopathogenesis. Here, we summarize the current literature on these antibody-independent B cell functions and identify remaining knowledge gaps. Читать дальше...



Human low-density lipoprotein receptor plays an important role in hepatitis B virus infection

Plos.org 

by Yingying Li, Guangxiang Luo

Hepatitis B virus (HBV) chronically infects more than 240 million people worldwide, resulting in chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HBV vaccine is effective to prevent new HBV infection but does not offer therapeutic benefit to hepatitis B patients. Neither are current antiviral drugs curative of chronic hepatitis B. A more thorough understanding of HBV infection and replication holds a great promise for identification of novel antiviral... Читать дальше...

Validating the Michigan Hand Outcomes Questionnaire in patients with rheumatoid arthritis using Rasch analysis

Plos.org 

by Mayank Jayaram, Chang Wang, Lu Wang, Kevin C. Chung

Introduction

The Michigan Hand Outcomes Questionnaire (MHQ) is a patient-reported outcome measure previously validated in patients with rheumatoid arthritis (RA) using classical test theory. Rasch analysis is a more rigorous method of questionnaire validation that has not been used to test the psychometric properties of the MHQ in patients with RA. The objective of this study is to evaluate the validity and reliability of the MHQ for... Читать дальше...

Assessing the level of digitalization and robotization in the enterprises of the European Union Member States

Plos.org 

by Jarosław Brodny, Magdalena Tutak

One of the main reasons for the dynamic global economic development observed in recent years is the process of digitalization, referred to as Industry 4.0. The significance of digitalization for this development is appreciated by the EU-27. In order for these actions to be effective, it is necessary to diagnose the current level of digitalization in the EU-27countries. The article presents the results of the assessment of the level of digitalization of enterprises in the EU-27 countries. Читать дальше...

Computationally efficient model of myocardial electromechanics for multiscale simulations

Plos.org 

by Fyodor Syomin, Anna Osepyan, Andrey Tsaturyan

A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the propagation velocity of the action potential, are also accounted for. The model reproduces changes in the twitch amplitude and Ca2+-transients upon... Читать дальше...

Thinking in pictures in everyday life situations among autistic adults

Plos.org 

by Clara Bled, Quentin Guillon, Isabelle Soulières, Lucie Bouvet

Autistic individuals are often described as thinking in pictures. The aim of this study was to investigate the phenomenological characteristics of mental representations and inner experiences of autistic individuals. A total of 39 autistic adults and 80 control adults answered an online questionnaire. Autistic participants reported a more frequent use of visual mental representations than controls for different types of everyday situations. Читать дальше...

Brown bear and Persian leopard attacks on humans in Iran

Plos.org 

by Jamshid Parchizadeh, Jerrold L. Belant

Large carnivore attacks on humans are a serious form of human-wildlife interaction which has increased globally in recent decades. When attacks occur, both humans and large carnivores suffer, highlighting the need to characterize these conflicts toward mitigation of attacks. We investigated brown bear (Ursus arctos) and Persian leopard (Panthera pardus) attacks on humans across Iran using reports provided by the Government of Iran during 2012–2020. Читать дальше...

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Москва

Машков соединил театр и кино


Institutional delivery and associated factors in rural communities of Central Gondar Zone, Northwest Ethiopia

Plos.org 

by Adane Nigusie, Telake Azale, Mezgebu Yitayal, Lemma Derseh

Introduction

Institutional delivery has been considered as one of the important strategies to improve maternal and child health and significantly reduces birth-related complications. However, it is still low in developing countries though there are some improvements. Hence, the aim of this study was to assess the prevalence of institutional delivery and associated factors in the study area.

Methods

A community-based cross-sectional study was conducted. Читать дальше...


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