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Новости за 25.01.2022

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Supplementing cultured human myotubes with hibernating bear serum results in increased protein content by modulating Akt/FOXO3a signaling

Plos.org 
En

by Mitsunori Miyazaki, Michito Shimozuru, Toshio Tsubota

Hibernating bears remain in their dens for 5–7 months during winter and survive without eating or drinking while staying inactive. However, they maintain their physical functions with minimal skeletal muscle atrophy and metabolic dysfunction. In bears, resistance to skeletal muscle atrophy during hibernation is likely mediated by seasonally altered systemic factors that are independent of neuromuscular activity. To determine whether... Читать дальше...

Placental malaria caused by Plasmodium vivax or P. falciparum in Colombia: Histopathology and mediators in placental processes

Plos.org 
En

by Jaime Carmona-Fonseca, Jaiberth Antonio Cardona-Arias

Knowledge about the relation of histopathological characteristics and mediators of physiological processes in the placenta malaria (PM) is poor, and that PM caused by Plasmodium vivax is almost null. The objective was to compare histopathological characteristics, cytokines and mediators of physiological processes in PM depending on the parasitic species, through a cross-sectional study in three groups: negative-PM, vivax-PM, falciparum-PM from Northwestern Colombia. Читать дальше...

Lingual bone thickness in the apical region of the horizontal mandibular third molar: A cross-sectional study in young Japanese

Plos.org 
En

by Shinpei Matsuda, Hitoshi Yoshimura

Background

Perforation of the lingual plate in the apical region of mandibular third molars will increase the risk of aberration and migration of the root tip and the risk of lingual nerve injury. The aim of this study was to analyze anatomical information, including relationships between the apical region of horizontally impacted mandibular third molars and lingual plates, in young Japanese.

Methods

Japanese patients, with horizontally impacted third molars... Читать дальше...

Development of multi-frequency impedance scanning electron microscopy

Plos.org 
En

by Toshihiko Ogura

Nanometre-scale observation of specimens in water is indispensable in many scientific fields like biology, chemistry, material science and nanotechnology. Scanning electron microscopy (SEM) allows high-resolution images of biological samples to be obtained under high vacuum conditions but requires specific sample-preparation protocols. Therefore, there is a need for convenient and minimally invasive methods of observing samples in solution. We have developed a new type of impedance microscopy... Читать дальше...



Strongy Detect: Preliminary Validation of a Prototype Recombinant Ss-NIE/Ss-IR Based ELISA to Detect Strongyloides stercoralis Infection

Plos.org 
En

by William J. Sears, Thomas B. Nutman

Background

Strongyloides stercoralis (Ss) is the etiological agent of strongyloidiasis, a neglected tropical disease of global concern. Laboratory diagnosis of strongyloidiasis is most often based on detection of antibodies against antigens in an enzyme linked immunosorbent assay (ELISA). Herein, we report a preliminary validation study of newly developed IgG4- and/or IgG- based ELISAs to detect strongyloidiasis (Strongy Detect, InBios) incorporating... Читать дальше...

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform

Plos.org 
En

by Krishnan Bhaskaran, Christopher T. Rentsch, George Hickman, William J. Hulme, Anna Schultze, Helen J. Curtis, Kevin Wing, Charlotte Warren-Gash, Laurie Tomlinson, Chris J. Bates, Rohini Mathur, Brian MacKenna, Viyaasan Mahalingasivam, Angel Wong, Alex J. Walker, Caroline E. Morton, Daniel Grint, Amir Mehrkar, Rosalind M. Eggo, Peter Inglesby, Ian J. Douglas, Helen I. McDonald, Jonathan Cockburn, Elizabeth J. Williamson, David Evans, John Parry, Frank Hester, Sam Harper, Stephen JW Evans, Sebastian Bacon... Читать дальше...

Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis

Plos.org 
En

by Geert-Jan Geersing, Toshihiko Takada, Frederikus A. Klok, Harry R. Büller, D. Mark Courtney, Yonathan Freund, Javier Galipienzo, Gregoire Le Gal, Waleed Ghanima, Jeffrey A. Kline, Menno V. Huisman, Karel G. M. Moons, Arnaud Perrier, Sameer Parpia, Helia Robert-Ebadi, Marc Righini, Pierre-Marie Roy, Maarten van Smeden, Milou A. M. Stals, Philip S. Wells, Kerstin de Wit, Noémie Kraaijpoel, Nick van Es

Читать дальше...

The estimates of effective population size based on linkage disequilibrium are virtually unaffected by natural selection

Plos.org 
En

by Irene Novo, Enrique Santiago, Armando Caballero

The effective population size (Ne) is a key parameter to quantify the magnitude of genetic drift and inbreeding, with important implications in human evolution. The increasing availability of high-density genetic markers allows the estimation of historical changes in Ne across time using measures of genome diversity or linkage disequilibrium between markers. Directional selection is expected to reduce diversity and Ne, and this reduction... Читать дальше...

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Does Mouthwash Actually Do Anything?

Lifehacker.com 
En

After brushing and flossing, mouthwash completes the trifecta of daily dental care. But do we really need all three steps? Dentists wouldn’t dare tell you to skip flossing or brushing, but it turns out they’re a lot more equivocal about mouthwash.

Читать дальше...

Staggering YouTube Shorts viewer numbers dominate latest YouTube CEO letter to community

Mashable 
En

It's that time of year again for YouTubers: 

YouTube CEO Susan Wojcicki has published this year's annual letter to the video platform's community and the big focus is clear: 2022 is going to be all about YouTube Shorts.

According to Wojcicki, YouTube Shorts content has hit "5 trillion all time views" on the platform. It appears clear in the letter that YouTube is very happy with how it's built-in shortform video platform – a way for the company to keep up with its competitor TikTok – is performing. Читать дальше...


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