CTP sensing and Mec1ATR-Rad53CHK1/CHK2 mediate a two-layered response to inhibition of glutamine metabolism
by Arta Ajazi, Ramveer Choudhary, Laura Tronci, Angela Bachi, Christopher Bruhn
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by Arta Ajazi, Ramveer Choudhary, Laura Tronci, Angela Bachi, Christopher Bruhn
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by Evan Quon, Aleksa Nenadic, Mohammad F. Zaman, Jesper Johansen, Christopher T. Beh
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by Timos Papadopoulos, Emilia Vynnycky
The basic reproduction number (R0) of an infection determines the impact of its control. For many endemic infections, R0 is often estimated from appropriate country-specific seroprevalence data. Studies sometimes pool estimates from the same region for settings lacking seroprevalence data, but the reliability of this approach is unclear. Plausibly, indicator-based approaches could predict R0 for such settings. We calculated R0 for rubella for 98 settings... Читать дальше...
by Shanglin Zhou, Sotiris C. Masmanidis, Dean V. Buonomano
Converging evidence suggests the brain encodes time in dynamic patterns of neural activity, including neural sequences, ramping activity, and complex dynamics. Most temporal tasks, however, require more than just encoding time, and can have distinct computational requirements including the need to exhibit temporal scaling, generalize to novel contexts, or robustness to noise. It is not known how neural circuits can encode time and satisfy distinct computational requirements... Читать дальше...
by Yibing Shan, Venkatesh P. Mysore, Abba E. Leffler, Eric T. Kim, Shiori Sagawa, David E. Shaw
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by Philip Gerlee, Philipp M. Altrock, Adam Malik, Cecilia Krona, Sven Nelander
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by Daniel R. Guest, Andrew J. Oxenham
Accurate pitch perception of harmonic complex tones is widely believed to rely on temporal fine structure information conveyed by the precise phase-locked responses of auditory-nerve fibers. However, accurate pitch perception remains possible even when spectrally resolved harmonics are presented at frequencies beyond the putative limits of neural phase locking, and it is unclear whether residual temporal information, or a coarser rate-place code, underlies this ability. Читать дальше...
by Jannes Jegminat, Maya A. Jastrzębowska, Matthew V. Pachai, Michael H. Herzog, Jean-Pascal Pfister
by Sebastiano Curreli, Jacopo Bonato, Sara Romanzi, Stefano Panzeri, Tommaso Fellin
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by Sylvain Tollis, Jaspal Singh, Roger Palou, Yogitha Thattikota, Ghada Ghazal, Jasmin Coulombe-Huntington, Xiaojing Tang, Susan Moore, Deborah Blake, Eric Bonneil, Catherine A. Royer, Pierre Thibault, Mike Tyers
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by Chris Lauber, Mathias J. Gerl, Christian Klose, Filip Ottosson, Olle Melander, Kai Simons
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by Ali Mahmoodi, Hamed Nili, Dan Bang, Carsten Mehring, Bahador Bahrami
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by Lonni Besançon, Elisabeth Bik, James Heathers, Gideon Meyerowitz-Katz
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The social network will test showing user-submitted fact checks on tweets to ordinary users, after research showed those checks can be helpful in countering misinformation.
Ever wanted to know more about the men and woman deciding the fate of those appearing in court? A new survey has revealed the majority of New Zealand's judges are men, 3.5 per cent identify as gay, lesbian ...
An exclusive look inside Tao Group's latest opening, where peasant Italian food goes luxe.
Snorkeling or diving over a coral reef, with its exceptionally vivid colors and proliferation of life in utterly unfamiliar forms, is about as close as most people get to visiting an alien world. The temptation is to try to take in the reef as a whole, but the true wonder lies in observing it up […]
Franny Moyle begins The King’s Painter, her substantial and copiously illustrated biography of Hans Holbein, with the story of Henry VIII’s hunt for a fourth wife. In 1539, two years after the death of Jane Seymour, he was looking for a bride from the German principalities, hoping for allies who would deter invasion threats from […]
The art critic Harold Rosenberg is remembered as a swashbuckling player in a sprawling American intellectual drama—a sort of epic family romance—that extended from the 1930s to the 1960s. The Old World was fading, the New World was taking center stage, and many American artists, writers, and thinkers were eager to celebrate what they saw […]
In early 2015 Alex Riley, then twenty-four years old, was working as a researcher at the Natural History Museum in London, using CT-scanning technology to study the teeth and skeletons of sharks and rays. A dinosaur fan since childhood, he was thrilled to be studying both living and extinct species in such detail, and he […]
The blackout curtains were drawn—it was night, I mean—though dawnshould have come. Beeches, maples, the dying horse-chestnuts, all had surrenderedto the general fall, like men to a cause notunderstood. Sacrifice I do not understand in the general sense. It had been a weekof the feathery rainthe trees were gluttons for—not punishment, but history. The passing […]
Bad Luck Banging, or Loony Porn, the Romanian director Radu Jude’s exuberantly rude and bawdy new film, is a movie about us. Or rather, it’s a comedy about our world: how we live under surveillance, with diminished boundaries, plagued by conspiratorial thinking and multiple pandemics—virtual as well as actual. As if tossed in a bottle, […]
On January 20, 1942, SS chief Heinrich Himmler’s deputy, Reinhard Heydrich, presided over a meeting at a villa on the shore of the Wannsee, a lake in an affluent Berlin suburb. Of the fifteen participants, eight held doctorates. They represented important ministries in Berlin, German occupation administrations on Polish and Soviet territory, and various SS […]
The website of the Nobel Prize Committee describes Louise Glück’s poetry as “free of poetic formalities” and notable, by contrast, for its use of “daily spoken language.” This has the distinction and utility of being almost exactly wrong. Rather, Glück subjects conventional poetic tropes to a rigorous process of abstraction until they become close to […]