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Новости за 18.03.2022

A pan-cancer analysis on the carcinogenic effect of human adenomatous polyposis coli

Plos.org 

by Yinci Zhang, Xinkuang Liu, Amin Li, Xiaolong Tang

Adenomatous polyposis coli (APC) is the most commonly mutated gene in colon cancer and can cause familial adenomatous polyposis (FAP). Hypermethylation of the APC promoter can also promote the development of breast cancer, indicating that APC is not limited to association with colorectal neoplasms. However, no pan-cancer analysis has been conducted. We studied the location and structure of APC and the expression and potential role of APC... Читать дальше...

Human state anxiety classification framework using EEG signals in response to exposure therapy

Plos.org 

by Farah Muhammad, Saad Al-Ahmadi

Human anxiety is a grave mental health concern that needs to be addressed in the appropriate manner in order to develop a healthy society. In this study, an objective human anxiety assessment framework is developed by using physiological signals of electroencephalography (EEG) and recorded in response to exposure therapy. The EEG signals of twenty-three subjects from an existing database called “A Database for Anxious States which is based on a Psychological... Читать дальше...

Priming attachment security and outgroup humanization: The mediation role of intergroup emotions

Plos.org 

by Dora Capozza, Rossella Falvo, Gian Antonio Di Bernardo

Individuals tend to dehumanize the outgroup. In this paper, we explore whether the activation of attachment security can attenuate dehumanization. Two studies were performed. In Study 1, attachment security was primed by showing pictures that depicted relationships with attachment figures; the outgroup was the homeless and humanization was measured considering the attribution of uniquely human and non-uniquely human emotions to this group. Читать дальше...

The association between academic achievement in physical education and timing of biological maturity in adolescents

Plos.org 

by Ruben Vist Hagen, Monika Haga, Hermundur Sigmundsson, Håvard Lorås

Individual differences in tempo and timing of biological maturity, especially in adolescents, has been argued as a potential underlying cause of relative age effects observed in Physical education (PE). Indeed, differences in maturation could influence pupils`achievement in PE where motor behavior and physical activity are central tenets. However, the timing of biological maturity has not previously been investigated in the context of academic achievement in PE. Читать дальше...



Why does it take so long for rare disease patients to get an accurate diagnosis?—A qualitative investigation of patient experiences of hereditary angioedema

Plos.org 

by Moeko Isono, Minori Kokado, Kazuto Kato

Introduction

Many patients with rare diseases experience a diagnostic delay. Although several quantitative studies have been reported, few studies have used a qualitative approach to directly examine how patients with rare disease obtain a diagnosis and why it takes many years. In this study, we focused on hereditary angioedema (HAE), which has been reported to have long diagnostic delays, despite the knowledge that not having an accurate diagnosis can cause life-threatening problems. Читать дальше...

Mathematical analysis of robustness of oscillations in models of the mammalian circadian clock

Plos.org 

by Xiangyu Yao, Benjamin L. Heidebrecht, Jing Chen, John J. Tyson

Circadian rhythms in a wide range of organisms are mediated by molecular mechanisms based on transcription-translation feedback. In this paper, we use bifurcation theory to explore mathematical models of genetic oscillators, based on Kim & Forger’s interpretation of the circadian clock in mammals. At the core of their models is a negative feedback loop whereby PER proteins (PER1 and PER2) bind to and inhibit their transcriptional activator, BMAL1. Читать дальше...

Metaproteomics as a tool for studying the protein landscape of human-gut bacterial species

Plos.org 

by Moses Stamboulian, Jamie Canderan, Yuzhen Ye

Host-microbiome interactions and the microbial community have broad impact in human health and diseases. Most microbiome based studies are performed at the genome level based on next-generation sequencing techniques, but metaproteomics is emerging as a powerful technique to study microbiome functional activity by characterizing the complex and dynamic composition of microbial proteins. We conducted a large-scale survey of human gut microbiome... Читать дальше...

Parameter inference for stochastic biochemical models from perturbation experiments parallelised at the single cell level

Plos.org 

by Anđela Davidović, Remy Chait, Gregory Batt, Jakob Ruess

Understanding and characterising biochemical processes inside single cells requires experimental platforms that allow one to perturb and observe the dynamics of such processes as well as computational methods to build and parameterise models from the collected data. Recent progress with experimental platforms and optogenetics has made it possible to expose each cell in an experiment to an individualised input and automatically record... Читать дальше...

Avalanches during epithelial tissue growth; Uniform Growth and a drosophila eye disc model

Plos.org 

by George Courcoubetis, Chi Xu, Sergey V. Nuzhdin, Stephan Haas

Epithelial tissues constitute an exotic type of active matter with non-linear properties reminiscent of amorphous materials. In the context of a proliferating epithelium, modeled by the quasistatic vertex model, we identify novel discrete tissue scale rearrangements, i.e. cellular rearrangement avalanches, which are a form of collective cell movement. During the avalanches, the vast majority of cells retain their neighbors, and... Читать дальше...

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Москва

Зной идет из Африки. Метеоролог Вильфанд: аномальная жара смертельно опасна


Economic recovery from Covid-19 threatened by geopolitical tension surrounding Ukraine

Engineeringnews.co.za 

Signs of a slow recovery in manufacturing so far this year – which were in part being driven by improvements in production in Europe and Asia – may now be threatened by escalating geopolitical tension in Europe on the back of the Russia-Ukraine conflict and a simultaneous resurgence of the Covid-19 virus in China, research and consulting firm Frost & Sullivan consulting analyst Nomvo Kasolo said on March 17. “However, pockets of opportunity exist for markets that can fill the gaps in exports from Russia,” she noted.

How ‘The Outfit’ Director Graham Moore Mined His Family History for a Twisty Crime Thriller About a Tailor

TheWrap.com 

Graham Moore is, by his own admission, not a very good planner.

The jump from winning the Oscar for Best Adapted Screenplay for the 2014 drama “The Imitation Game” to making his directorial debut with a noir-inspired crime thriller was not part of some grand design to one day get behind the camera. In fact, Moore followed the “surreal and overwhelming” experience of winning an Academy Award with writing a book.

“There was a lot of attention, and I went home at the end of all... Читать дальше...

'Deep Water,' neither thriller nor erotic, sinks hard

The Toledo Blade 

Meet Vic and Melinda Van Allen, the yin and yang of the country club circuit. He likes to brood; she likes to dance. He's a teetotaler; she's a lush. He rather likes monogamy; she likes to nuzzle other men in front of her husband. Actually, on second thought, maybe steer clear entirely of the Van Allens — or their movie.

Library expands service with free internet hotspots

The Toledo Blade 

It is critical to have access to our digitally connected world, yet many can’t afford to pay the high cost of internet service which is why the Toledo Lucas County Public Library system has stepped in to fill that gap by providing free mobile wi-fi hotspots.


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