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Новости за 21.03.2022

Keep your budget together! Investigating determinants on risky decision-making about losses

Plos.org 

by Marc Wyszynski, Adele Diederich

The present study investigates the influence of framing, different amounts to lose, and probabilities of a risky and sure choice option, time limits, and need on risky decision-making. For a given block of trials, participants were equipped with a personal budget (number of points). On each trial within a block, a specific initial amount is possibly taken from the budget by the outcome of a gamble or the choice of a sure loss option. The goal was to avoid... Читать дальше...

Several different sequences are implicated in bloodstream-form-specific gene expression in Trypanosoma brucei

Plos.org 

by Tania Bishola Tshitenge, Lena Reichert, Bin Liu, Christine Clayton

The parasite Trypanosoma brucei grows as bloodstream forms in mammalian hosts, and as procyclic forms in tsetse flies. In trypanosomes, gene expression regulation depends heavily on post-transcriptional mechanisms. Both the RNA-binding protein RBP10 and glycosomal phosphoglycerate kinase PGKC are expressed only in mammalian-infective forms. RBP10 targets procyclic-specific mRNAs for destruction, while PGKC is required for bloodstream-form glycolysis. Читать дальше...



Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment

Plos.org 

by Suzan Farhang-Sardroodi, Michael A. La Croix, Kathleen P. Wilkie

Although chemotherapy is a standard treatment for cancer, it comes with significant side effects. In particular, certain agents can induce severe muscle loss, known as cachexia, worsening patient quality of life and treatment outcomes. 5-fluorouracil, an anti-cancer agent used to treat several cancers, has been shown to cause muscle loss. Experimental data indicates a non-linear dose-dependence for muscle loss in mice treated with daily or week-day schedules. Читать дальше...

Determining clinically relevant features in cytometry data using persistent homology

Plos.org 

by Soham Mukherjee, Darren Wethington, Tamal K. Dey, Jayajit Das

Cytometry experiments yield high-dimensional point cloud data that is difficult to interpret manually. Boolean gating techniques coupled with comparisons of relative abundances of cellular subsets is the current standard for cytometry data analysis. However, this approach is unable to capture more subtle topological features hidden in data, especially if those features are further masked by data transforms or significant batch... Читать дальше...

Large self-assembled clathrin lattices spontaneously disassemble without sufficient adaptor proteins

Plos.org 

by Si-Kao Guo, Alexander J. Sodt, Margaret E. Johnson

Clathrin-coated structures must assemble on cell membranes to internalize receptors, with the clathrin protein only linked to the membrane via adaptor proteins. These structures can grow surprisingly large, containing over 20 clathrin, yet they often fail to form productive vesicles, instead aborting and disassembling. We show that clathrin structures of this size can both form and disassemble spontaneously when adaptor protein availability is low, despite high abundance of clathrin.

Where are the moons that orbit exoplanets?

The Planetary Society 

Astronomers are searching for exomoons, or moons orbiting exoplanets. Although this idea has been around for a while, astronomers have only recently started having success in finding these elusive worlds.

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Oil Prices Jump As European Countries Consider Banning Russian Crude

Oilprice.com 

Oil prices rallied early on Monday amid EU consultations about potentially joining the U.S. in banning imports of Russian oil. As of 7:45 a.m. ET on Monday, WTI Crude was up 3.87% at $108.91 and Brent Crude was trading up 3.93% at $112.30.  Separately, prices were driven higher after an attack from the Iran-aligned Houthi rebels over the weekend targeted energy facilities in Saudi Arabia, the world’s top oil exporter and de facto leader of OPEC. According to the Saudi energy ministry, strikes carried... Читать дальше...


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