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Новости за 24.03.2022

Isotope-assisted metabolic flux analysis as an equality-constrained nonlinear program for improved scalability and robustness

Plos.org 

by Daniel J. Lugar, Ganesh Sriram

Stable isotope-assisted metabolic flux analysis (MFA) is a powerful method to estimate carbon flow and partitioning in metabolic networks. At its core, MFA is a parameter estimation problem wherein the fluxes and metabolite pool sizes are model parameters that are estimated, via optimization, to account for measurements of steady-state or isotopically-nonstationary isotope labeling patterns. As MFA problems advance in scale, they require efficient computational methods for fast and robust convergence. Читать дальше...

Speed Up Meal Prep With These Ingredient Shortcuts

TheTakeout.com 

You’ve no doubt seen the Nancy Meyers ideal of cooking. A breezy, expansive kitchen with unlimited counter space, plus an enormous double oven big enough to fit two Thanksgiving turkeys and an unfortunate child who’s just escaped the local orphanage. For most of us, that’s not the reality. We’re cooking in apartment…

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Montana's Northwestern Energy customers get day in court

MtStandard.com 

Customers of NorthWestern Energy, alleging they’ve for years been overbilled for power plants due to a state law written especially for the utility, got their day in court Wednesday in Missoula County District Court.

BA.2 COVID variant: Who should worry about severe COVID symptoms? - Deseret News

Sports - Google News (us) 

  1. BA.2 COVID variant: Who should worry about severe COVID symptoms?  Deseret News
  2. BA.2 COVID variant is spreading in parts of the US, but cases remain low in Houston  KHOU 11
  3. The BA.2 Omicron subvariant is now dominant in northeastern US states, per CDC data. Some experts warn of an impending new wave.  Yahoo! Voices
  4. Omicron BA.2 subvariant will soon dominate in U.S., but Fauci doesn't expect another surge  CNBC
  5. What to know about COVID omicron variant BA.2 ... Читать дальше...

Bad Sisters First Look: Apple TV+ Reveals First Photo and Casting of Sharon Horgan's Dark Comedy

Блог сайта «Face Tube is a fun name,» 

Someone is on a roll!

Today, Apple TV+ announced the title and cast, and unveiled a first-look at Bad Sisters, its highly anticipated 10 episode series from Emmy Award-nominee and BAFTA Award-winning star and creator Sharon Horgan (Catastrophe, Shining Vale) which is set to debut later this year.

Horgan is continually one to watch both on screen and behind the scenes, so this is very exciting news.

While there isn't a premiere date yet, we have your first look with... Читать дальше...

Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8+ T cells of HIV-infected individuals

Plos.org 

by Shima Shahbaz, Isobel Okoye, Gregg Blevins, Shokrollah Elahi

CD8+ T cells play a crucial role against chronic viral infections, however, their effector functions are influenced by the expression of co-stimulatory/inhibitory receptors. For example, CD73 works with CD39 to convert highly inflammatory ATP to adenosine. However, its expression on T cells in the context of viral infections has not been well defined. Here, we analyzed the expression of CD73 on human T cells in a cohort of 102... Читать дальше...

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Москва

Обновление Павелецкого направления: что ждёт пассажиров после Ярославского?


Quantifying wedge-tailed shearwater (Ardenna pacifica) fallout after changes in highway lighting on Southeast Oʻahu, Hawaiʻi

Plos.org 

by Jennifer Urmston, K. David Hyrenbach, Keith Swindle

Attraction to artificial light at night (ALAN) poses a threat to many fledgling seabirds leaving their nests for the first time. In Hawaiʻi, fledgling wedge-tailed shearwaters disoriented by lights may become grounded due to exhaustion or collision, exposing them to additional threats from road traffic and predation. While the timing and magnitude of shearwater fallout varies from year to year, little is known about how changing lighting... Читать дальше...


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