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2022

Новости за 28.03.2022

Community intervention programmes with people affected by leprosy: Listening to the voice of professionals

Plos.org 

by Gema Martos-Casado, Carmen Vives-Cases, Diana Gil-González

Background

Community participation and implementing interventions based on the community are key strategies to eliminate leprosy. Health professionals have an essential role as they are a necessary source of information because of their knowledge and experience, as well as their comprehensive perspective of contexts included in the programmes. This study has the aim of analysing the perceptions on the development of programmes... Читать дальше...

Imbalanced segregation of recombinant haplotypes in hybrid populations reveals inter- and intrachromosomal Dobzhansky-Muller incompatibilities

Plos.org 

by Juan Li, Molly Schumer, Claudia Bank

Dobzhansky-Muller incompatibilities (DMIs) are a major component of reproductive isolation between species. DMIs imply negative epistasis and are exposed when two diverged populations hybridize. Mapping the locations of DMIs has largely relied on classical genetic mapping. Approaches to date are hampered by low power and the challenge of identifying DMI loci on the same chromosome, because strong initial linkage of parental haplotypes weakens statistical tests. Читать дальше...



How the storage effect and the number of temporal niches affect biodiversity in stochastic and seasonal environments

Plos.org 

by Immanuel Meyer, Bnaya Steinmetz, Nadav M. Shnerb

Temporal environmental variations affect diversity in communities of competing populations. In particular, the covariance between competition and environment is known to facilitate invasions of rare species via the storage effect. Here we present a quantitative study of the effects of temporal variations in two-species and in diverse communities. Four scenarios are compared: environmental variations may be either periodic (seasonal) or stochastic... Читать дальше...

Pooled testing of traced contacts under superspreading dynamics

Plos.org 

by Stratis Tsirtsis, Abir De, Lars Lorch, Manuel Gomez-Rodriguez

Testing is recommended for all close contacts of confirmed COVID-19 patients. However, existing pooled testing methods are oblivious to the circumstances of contagion provided by contact tracing. Here, we build upon a well-known semi-adaptive pooled testing method, Dorfman’s method with imperfect tests, and derive a simple pooled testing method based on dynamic programming that is specifically designed to use information provided by contact tracing. Читать дальше...

Survival analysis of pathway activity as a prognostic determinant in breast cancer

Plos.org 

by Gustavo S. Jeuken, Nicholas P. Tobin, Lukas Käll

High throughput biology enables the measurements of relative concentrations of thousands of biomolecules from e.g. tissue samples. The process leaves the investigator with the problem of how to best interpret the potentially large numbers of differences between samples. Many activities in a cell depend on ordered reactions involving multiple biomolecules, often referred to as pathways. It hence makes sense to study differences between samples in terms of altered pathway activity... Читать дальше...

Responsible handling of ethics in data publication

Plos.org 

by Daniella Lowenberg, Iratxe Puebla

A global working group has developed recommendations for the responsible handling of the growing range of ethics cases related to data publication, but further community work is needed toward a responsible and cohesive data publishing ecosystem. A global working group has developed recommendations for the responsible handling of research data publication ethics, but there are further steps that repositories, publishers, institutions, and researchers can... Читать дальше...

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Jake Owen, Incubus coming to Pinewood Bowl

JournalStar.com 

Owen's concert will mark his first appearance at Pinewood after playing Pinnacle Bank Arena in 2014. He also headlined Frog Fest south of Lincoln in 2017.


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