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Новости за 31.03.2022

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An analysis framework for clustering algorithm selection with applications to spectroscopy

Plos.org 
En

by Simon Crase, Suresh N. Thennadil

Cluster analysis is a valuable unsupervised machine learning technique that is applied in a multitude of domains to identify similarities or clusters in unlabelled data. However, its performance is dependent of the characteristics of the data it is being applied to. There is no universally best clustering algorithm, and hence, there are numerous clustering algorithms available with different performance characteristics. This raises the problem of how to... Читать дальше...

Tracing back variations in archaeal ESCRT-based cell division to protein domain architectures

Plos.org 
En

by Béla P. Frohn, Tobias Härtel, Jürgen Cox, Petra Schwille

The Endosomal Sorting Complex Required for Transport (ESCRT) system is a multi-protein machinery that is involved in cell division of both Eukaryotes and Archaea. This spread across domains of life suggests that a precursor ESCRT machinery existed already at an evolutionary early stage of life, making it a promising candidate for the (re)construction of a minimal cell division machinery. There are, however, only few experimental data about ESCRT machineries in Archaea... Читать дальше...

Impact of ACA implementation on health related quality of life among those with depressive disorders in the United States: A secondary data analysis of the 2011-2017 BRFSS

Plos.org 
En

by Kathryn Mazurek, Wei Xue, Marissa Beldon

Purpose

The passage of the Affordable Care Act in the US resulted in more Americans with health insurance coverage as well as expanded health benefits. However, barriers in accessing health care still exist in the US especially as it relates to some of the most vulnerable Americans including those with depressive disorders. The purpose of this cross-sectional secondary data analysis was to examine the differences in health-related quality of life... Читать дальше...

Clinical effectiveness of beta-lactams versus fluoroquinolones as empirical therapy in patients with diabetes mellitus hospitalized for urinary tract infections: A retrospective cohort study

Plos.org 
En

by Yu-Hsin Tang, Po-Liang Lu, Ho-Yin Huang, Ying-Chi Lin

Background

Diabetic patients are at risk of severe urinary tract infections (UTIs). Due to the emerging resistance rates to fluoroquinolones and β-lactams, we aimed to evaluate the effectiveness of β-lactams versus fluoroquinolones as empirical therapy for diabetic patients hospitalized for UTIs.

Methods

A retrospective cohort study was conducted in a medical center in Taiwan between 2016 and 2018. Patients with type 2 diabetes... Читать дальше...



Disentangling snakebite dynamics in Colombia: How does rainfall and temperature drive snakebite temporal patterns?

Plos.org 
En

by Carlos Bravo-Vega, Mauricio Santos-Vega, Juan Manuel Cordovez

The role of climate driving zoonotic diseases’ population dynamics has typically been addressed via retrospective analyses of national aggregated incidence records. A central question in epidemiology has been whether seasonal and interannual cycles are driven by climate variation or generated by socioeconomic factors. Here, we use compartmental models to quantify the role of rainfall and temperature in the dynamics of snakebite... Читать дальше...

Quantification of long-term doxorubicin response dynamics in breast cancer cell lines to direct treatment schedules

Plos.org 
En

by Grant R. Howard, Tyler A. Jost, Thomas E. Yankeelov, Amy Brock

While acquired chemoresistance is recognized as a key challenge to treating many types of cancer, the dynamics with which drug sensitivity changes after exposure are poorly characterized. Most chemotherapeutic regimens call for repeated dosing at regular intervals, and if drug sensitivity changes on a similar time scale then the treatment interval could be optimized to improve treatment performance. Theoretical work suggests that such optimal schedules exist... Читать дальше...

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