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2022

Новости за 29.04.2022

α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain

Plos.org 

by Manh Tin Ho, Jiongming Lu, Paula Vazquez-Pianzola, Beat Suter

The alpha subunit of the cytoplasmic Phenylalanyl tRNA synthetase (α-PheRS, FARSA in humans) displays cell growth and proliferation activities and its elevated levels can induce cell fate changes and tumor-like phenotypes that are neither dependent on the canonical function of charging tRNAPhe with phenylalanine nor on stimulating general translation. In intestinal stem cells of Drosophila midguts, α-PheRS levels are naturally... Читать дальше...



Context coding in the mouse nucleus accumbens modulates motivationally relevant information

Plos.org 

by Jimmie M. Gmaz, Matthijs A. A. van der Meer

Neural activity in the nucleus accumbens (NAc) is thought to track fundamentally value-centric quantities linked to reward and effort. However, the NAc also contributes to flexible behavior in ways that are difficult to explain based on value signals alone, raising the question of if and how nonvalue signals are encoded in NAc. We recorded NAc neural ensembles while head-fixed mice performed an odor-based biconditional discrimination task where... Читать дальше...

How Hatching’s charmingly terrifying monster was brought to life

The Verge 

The Hatching monster hiding under a bed. | Image: IFC Films

Animatronics designer Gustav Hoegen has worked on some of the biggest film franchises around. He’s helped bring to life the likes of the adorable mechanic Babu Frik from Rise of the Skywalker and the towering engineer from Prometheus. But some of the most stressful experiences in his career came on the set of Hatching, a Finnish body horror movie that debuted at Sundance and premieres in theaters and on-demand today. Unlike those productions... Читать дальше...

Mariners Moose Tracks, 4/29/22: Ronald Acuña, Jr., Adalberto Mondesi, and Kyle Bradish

Lookout Landing 

Brett Davis-USA TODAY Sports

It’s Friday everyone!

Good morning and happy Friday! Let’s get you caught up on the latest from around baseball.

In Mariners news...

  • In case you missed it, Penn Murfee and Wyatt Mills were recalled from Tacoma yesterday as Yohan Ramírez and Cal Raleigh were sent down. And no, they were not able to catch Murfee before he boarded his flight back to Seattle.

Around the league...

  • So I guess the ball is dead.
... Читать дальше...

The Dark Side of Collaboration

Sciam.com 

People working together often scheme to put profits ahead of telling the truth. New research points to ways to stop this behavior

-- Read more on ScientificAmerican.com

Tom Cruise unveils ‘Top Gun’ sequel with mid-air stunt

Times of Malta 

Tom Cruise unveiled the world-first screening of Top Gun: Maverick at CinemaCon in Las Vegas on Thursday − introducing the long-awaited sequel while balanced atop a flying bi-plane. The new Top Gun, which picks up the story of Maverick and his fighter pilot buddies some three decades after the blockbuster original, was scheduled to open in 2020 but was repeatedly delayed by the COVID-19 pandemic. Cruise, famous for doing many of his own stunts, introduced the screening to the movie theatre industry... Читать дальше...


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