by Haypheng Te, Pimolpachr Sriburin, Jittraporn Rattanamahaphoom, Pichamon Sittikul, Weerawan Hattasingh, Supawat Chatchen, Salin Sirinam, Kriengsak Limkittikul

Beyond Lassa Fever: Systemic and structural barriers to disease detection and response in Sierra Leone

19.05.2022 17:00

Plos.org

by Hana Rohan

Background

Lassa fever (LF) often presents clinically as undifferentiated febrile illness. Lassa Fever cases in Sierra Leone have been falling since the 2014–2016 Ebola epidemic. Data from other LF endemic countries suggest that this is not a true reflection of local epidemiological decline, but rather a function of either health seeking behaviour or the health/referral system. In Sierra Leone, many other diseases present with a similar early clinical picture, including COVID-19... Читать дальше...

Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study

19.05.2022 17:00

Plos.org

by Sam Hodgson, Qin Qin Huang, Neneh Sallah, Genes & Health Research Team , Chris J. Griffiths, William G. Newman, Richard C. Trembath, John Wright, R. Thomas Lumbers, Karoline Kuchenbaecker, David A. van Heel, Rohini Mathur, Hilary C. Martin, Sarah Finer

Extending precision medicine tools to populations at high risk of type 2 diabetes

19.05.2022 17:00

Plos.org

by Shivani Misra, Jose C. Florez

In this Perspective, Shivani Misra and Jose C Florez discuss the application of precision medicine tools in under-represented populations.

Increased genetic contribution to wellbeing during the COVID-19 pandemic

19.05.2022 17:00

Plos.org

by C. A. Robert Warmerdam, Henry H. Wiersma, Pauline Lanting, Alireza Ani, Lifelines Corona Research Initiative , Lifelines Cohort Study , Marjolein X. L. Dijkema, Harold Snieder, Judith M. Vonk, H. Marike Boezen, Patrick Deelen, Lude H. Franke

MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

19.05.2022 17:00

Plos.org

by Meenalakshmi Chinnam, Chao Xu, Rati Lama, Xiaojing Zhang, Carlos D. Cedeno, Yanqing Wang, Aimee B. Stablewski, David W. Goodrich, Xinjiang Wang

Ustilago maydis telomere protein Pot1 harbors an extra N-terminal OB fold and regulates homology-directed DNA repair factors in a dichotomous and context-dependent manner

19.05.2022 17:00

Plos.org

by Syed Zahid, Sarah Aloe, Jeanette H. Sutherland, William K. Holloman, Neal F. Lue

A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila

19.05.2022 17:00

Plos.org

by Aarthi Kuppannan, Yu-Yang Jiang, Wolfgang Maier, Chang Liu, Charles F. Lang, Chao-Yin Cheng, Mark C. Field, Minglei Zhao, Martin Zoltner, Aaron P. Turkewitz

A computational model of stereoscopic prey capture in praying mantises

19.05.2022 17:00

Plos.org

by James O’Keeffe, Sin Hui Yap, Ichasus Llamas-Cornejo, Vivek Nityananda, Jenny C. A. Read

LncRNAs of Saccharomyces cerevisiae bypass the cell cycle arrest imposed by ethanol stress

19.05.2022 17:00

Plos.org

by Lucas Cardoso Lázari, Ivan Rodrigo Wolf, Amanda Piveta Schnepper, Guilherme Targino Valente

Scalable and flexible inference framework for stochastic dynamic single-cell models

19.05.2022 17:00

Plos.org

by Sebastian Persson, Niek Welkenhuysen, Sviatlana Shashkova, Samuel Wiqvist, Patrick Reith, Gregor W. Schmidt, Umberto Picchini, Marija Cvijovic

Enhancing long-term forecasting: Learning from COVID-19 models

19.05.2022 17:00

Plos.org

by Hazhir Rahmandad, Ran Xu, Navid Ghaffarzadegan

While much effort has gone into building predictive models of the COVID-19 pandemic, some have argued that early exponential growth combined with the stochastic nature of epidemics make the long-term prediction of contagion trajectories impossible. We conduct two complementary studies to assess model features supporting better long-term predictions. First, we leverage the diverse models contributing to the CDC repository of COVID-19 USA death... Читать дальше...

CystiHuman: A model of human neurocysticercosis

19.05.2022 17:00

Plos.org

by Gabrielle Bonnet, Francesco Pizzitutti, Eloy A. Gonzales-Gustavson, Sarah Gabriël, William K. Pan, Hector H. Garcia, Javier A. Bustos, Percy Vilchez, Seth E. O’Neal, for the Cysticercosis Working Group in Peru

Linear viscoelastic properties of the vertex model for epithelial tissues

19.05.2022 17:00

Plos.org

by Sijie Tong, Navreeta K. Singh, Rastko Sknepnek, Andrej Košmrlj

Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune their mechanical properties to change the overall response of the tissue, e.g., from solid-like to fluid-like. Mesoscopic mechanical properties of epithelia are commonly modeled with the vertex model. Читать дальше...

Новости России

Москва

Глобальное масштабирование: компания «Газинформсервис» участвует в обсуждении применения электронной транспортной накладной с ЕЭК ООН

Major environmental drivers determining life and death of cold-water corals through time

19.05.2022 17:00

Plos.org

by Rodrigo da Costa Portilho-Ramos, Jürgen Titschack, Claudia Wienberg, Michael Georg Siccha Rojas, Yusuke Yokoyama, Dierk Hebbeln

Hubble Reaches New Milestone in Mystery of Universe's Expansion Rate

19.05.2022 17:00

Nasa.gov

Completing a nearly 30-year marathon, NASA's Hubble Space Telescope has calibrated more than 40 "milepost markers" of space and time to help scientists precisely measure the expansion rate of the universe.