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Новости за 11.08.2022

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Predicting curve progression for adolescent idiopathic scoliosis using random forest model

Plos.org 
En

by Ausilah Alfraihat, Amer F. Samdani, Sriram Balasubramanian

Background

Adolescent Idiopathic Scoliosis (AIS) is a three-dimensional (3D) spinal deformity characterized by coronal curvature and rotational deformity. Predicting curve progression is important for the selection and timing of treatment. Although there is a consensus in the literature regarding prognostic factors associated with curve progression, the order of importance, as well as the combination of factors that are most predictive of curve progression is unknown. Читать дальше...

Molecular epidemiology of bovine tuberculosis in Northern Ghana identifies several uncharacterized bovine spoligotypes and suggests possible zoonotic transmission

Plos.org 
En

by Samuel Ekuban Kobina Acquah, Prince Asare, Emelia Konadu Danso, Phillip Tetteh, Amanda Yaa Tetteh, Daniel Boateng, Stephen Osei-Wusu, Theophilus Afum, Yolanda Isabel Ayamdooh, Eric Agongo Akugre, Omar Abdul Samad, Lawrence Quaye, Kwasi Obiri-Danso, Richard Kock, Adwoa Asante-Poku, Dorothy Yeboah-Manu

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Lipids and atrial fibrillation: New insights into a paradox

Plos.org 
En

by Dimitrios Sagris, Stephanie L. Harrison, Gregory Y. H. Lip

In this Perspective, Dimitrios Sagris, Stephanie Harrison, and Gregory Lip discuss new evidence concerning the paradoxical relationship between circulating lipids and atrial fibrillation.



Scelestial: Fast and accurate single-cell lineage tree inference based on a Steiner tree approximation algorithm

Plos.org 
En

by Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Alice C. McHardy

Single-cell genome sequencing provides a highly granular view of biological systems but is affected by high error rates, allelic amplification bias, and uneven genome coverage. This creates a need for data-specific computational methods, for purposes such as for cell lineage tree inference. The objective of cell lineage tree reconstruction is to infer the evolutionary process that generated a set of observed cell genomes. Читать дальше...

Nine quick tips for pathway enrichment analysis

Plos.org 
En

by Davide Chicco, Giuseppe Agapito

Pathway enrichment analysis (PEA) is a computational biology method that identifies biological functions that are overrepresented in a group of genes more than would be expected by chance and ranks these functions by relevance. The relative abundance of genes pertinent to specific pathways is measured through statistical methods, and associated functional pathways are retrieved from online bioinformatics databases. In the last decade, along with the spread of the internet... Читать дальше...

Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer’s disease drug repurposing

Plos.org 
En

by You Wu, Qiao Liu, Yue Qiu, Lei Xie

Predictive modeling of drug-induced gene expressions is a powerful tool for phenotype-based compound screening and drug repurposing. State-of-the-art machine learning methods use a small number of fixed cell lines as a surrogate for predicting actual expressions in a new cell type or tissue, although it is well known that drug responses depend on a cellular context. Thus, the existing approach has limitations when applied to personalized medicine, especially... Читать дальше...

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Летний мультпоказ: «Шимми: первый король обезьян» в ТРЦ «Нора»


Al-Shabaab terrorists execute 6 in Somalia

En.mehrnews.com 
En

TEHRAN, Aug. 11 (MNA) – News sources reported that the Al-Shabaab terrorists executed 6 people in southern Somalia on charges of espionage.

Joanna Gaines Opens Up About 20-Year Marriage to Chip: 'Experienced a Little Bit of All of It'

AOL.com 
En

Cindy Ord/Getty/SiriusXM

Joanna Gaines and Chip Gaines' nearly 20-year marriage has weathered its fair share of difficult times, she says.

The 44-year-old Fixer Upper star penned a personal essay for the new fall issue of Magnolia Journal (out Friday, Aug. 12), and opened up the obstacles she and Chip have overcome. (Magnolia Journal is published by PEOPLE's parent company Dotdash Meredith.)

"In our 20 years of marriage, Chip and I have experienced a little bit of all of it," Joanna writes. Читать дальше...


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