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Новости за 29.08.2022

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A scoping review protocol to elucidate outcomes following abiraterone versus enzalutamide for prostate cancer

Plos.org 
En

by Yash B. Shah, Amy L. Shaver, William Kevin Kelly, Grace Lu-Yao

Introduction

Abiraterone acetate and enzalutamide are commonly employed in prostate cancer therapy in an interchangeable manner. These drugs are highly efficacious in androgen antagonism to improve patient outcomes, but they also carry noteworthy risk of adverse effects. Common toxicities vary amongst the two drugs and may have differential interactions with patient co-morbidities, but these patterns are unclear as co-morbidities... Читать дальше...

Development and validation of the predictive score for pediatric COVID-19 pneumonia: A nationwide, multicenter study

Plos.org 
En

by Araya Satdhabudha, Chanapai Chaiyakulsil, Rattapon Uppala, Watit Niyomkarn, Prakarn Tovichien, Vasinee Norasettekul, Kanokpan Ruangnapa, Chutima Smathakanee, Bararee Choursamran, Aunya Kulbun, Rasintra Jaroenying, Harutai Kamalaporn, Tidarat Sriboonyong, Koonkoaw Roekworachai, Kanokkarn Sunkonkit, Auchara Tangsathapornpong, Pornumpa Bunjoungmanee, Wanida Pao-in, Patcharapa Thaweekul, Pichaya Tantiyavarong, Thanyarat Ratanavongkosol, Chutima Thongnual, Paskorn Sritipsukho, Jitladda Deerojanawong

... Читать дальше...

Are women with disabilities less likely to utilize essential maternal and reproductive health services?—A secondary analysis of Pakistan Demographic Health Survey

Plos.org 
En

by Shafaq Mahmood, Waqas Hameed, Sameen Siddiqi

Background

People with disabilities deal with widespread exclusion from healthcare services, including sexual and reproductive health (SRH) rights. Studies analyzing the relationship between disability and key SRH utilization outcomes have often reported mixed findings. In Pakistan, very little to no literature is available on this topic, therefore we aim to determine inequalities in the utilization of essential maternal and reproductive health... Читать дальше...



Multiscale modelling of desquamation in the interfollicular epidermis

Plos.org 
En

by Claire Miller, Edmund Crampin, James M. Osborne

Maintenance of epidermal thickness is critical to the barrier function of the skin. Decreased tissue thickness, specifically in the stratum corneum (the outermost layer of the tissue), causes discomfort and inflammation, and is related to several severe diseases of the tissue. In order to maintain both stratum corneum thickness and overall tissue thickness it is necessary for the system to balance cell proliferation and cell loss. Cell proliferation... Читать дальше...

A simple model of the attentional blink and its modulation by mental training

Plos.org 
En

by Nadav Amir, Naftali Tishby, Israel Nelken

The attentional blink (AB) effect is the reduced probability of reporting a second target (T2) that appears shortly after a first one (T1) within a rapidly presented sequence of distractors. The AB effect has been shown to be reduced following intensive mental training in the form of mindfulness meditation, with a corresponding reduction in T1-evoked P3b brain potentials. However, the mechanisms underlying these effects remain unknown. We propose a dynamical-systems model of the AB... Читать дальше...

Accounting for multiple imputation-induced variability for differential analysis in mass spectrometry-based label-free quantitative proteomics

Plos.org 
En

by Marie Chion, Christine Carapito, Frédéric Bertrand

Imputing missing values is common practice in label-free quantitative proteomics. Imputation aims at replacing a missing value with a user-defined one. However, the imputation itself may not be optimally considered downstream of the imputation process, as imputed datasets are often considered as if they had always been complete. Hence, the uncertainty due to the imputation is not adequately taken into account. We provide a rigorous multiple imputation strategy... Читать дальше...

Новости России
Москва

Стоит ли отдавать ребенка в частную школу?


Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits

Plos.org 
En

by Naoto Kubota, Mikita Suyama

Genomic variations are associated with gene expression levels, which are called expression quantitative trait loci (eQTL). Most eQTL may affect the total gene expression levels by regulating transcriptional activities of a specific promoter. However, the direct exploration of genomic loci associated with promoter activities using RNA-seq data has been challenging because eQTL analyses treat the total expression levels estimated by summing those of all isoforms transcribed from distinct promoters. Читать дальше...

Elephant Rumblings: A’s commemorate anniversary of the streak

Athletics Nation 
En

OAKLAND, CALIFORNIA - AUGUST 28: Former Major Leaguer and member of the Oakland Athletics Miguel Tejada throws out the ceremonial first pitch prior to the start of the game against the New York Yankees at RingCentral Coliseum on August 28, 2022 in Oakland, California. Tejada and the Athletics celebrated a twenty year reunion with the 20-game win streak team from 2002. | Photo by Thearon W. Henderson/Getty Images

MLB news roundup

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ATP

Янник Синнер не приедет на турнир ATP-500 в Вену






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Спонсорский контент

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