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Новости за 12.09.2022

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TAMC: A deep-learning approach to predict motif-centric transcriptional factor binding activity based on ATAC-seq profile

Plos.org 
En

by Tianqi Yang, Ricardo Henao

Determining transcriptional factor binding sites (TFBSs) is critical for understanding the molecular mechanisms regulating gene expression in different biological conditions. Biological assays designed to directly mapping TFBSs require large sample size and intensive resources. As an alternative, ATAC-seq assay is simple to conduct and provides genomic cleavage profiles that contain rich information for imputing TFBSs indirectly. Previous footprint-based tools... Читать дальше...

Rhythmicity is linked to expression cost at the protein level but to expression precision at the mRNA level

Plos.org 
En

by David Laloum, Marc Robinson-Rechavi

Many genes have nycthemeral rhythms of expression, i.e. a 24-hours periodic variation, at either mRNA or protein level or both, and most rhythmic genes are tissue-specific. Here, we investigate and discuss the evolutionary origins of rhythms in gene expression. Our results suggest that rhythmicity of protein expression could have been favored by selection to minimize costs. Trends are consistent in bacteria, plants and animals, and are also supported by tissue-specific patterns in mouse. Читать дальше...

A quantitative modelling approach for DNA repair on a population scale

Plos.org 
En

by Leo Zeitler, Cyril Denby Wilkes, Arach Goldar, Julie Soutourina

The great advances of sequencing technologies allow the in vivo measurement of nuclear processes—such as DNA repair after UV exposure—over entire cell populations. However, data sets usually contain only a few samples over several hours, missing possibly important information in between time points. We developed a data-driven approach to analyse CPD repair kinetics over time in Saccharomyces cerevisiae. In contrast to other... Читать дальше...

RNA velocity unraveled

Plos.org 
En

by Gennady Gorin, Meichen Fang, Tara Chari, Lior Pachter

We perform a thorough analysis of RNA velocity methods, with a view towards understanding the suitability of the various assumptions underlying popular implementations. In addition to providing a self-contained exposition of the underlying mathematics, we undertake simulations and perform controlled experiments on biological datasets to assess workflow sensitivity to parameter choices and underlying biology. Finally, we argue for a more rigorous approach to RNA velocity... Читать дальше...

PrMFTP: Multi-functional therapeutic peptides prediction based on multi-head self-attention mechanism and class weight optimization

Plos.org 
En

by Wenhui Yan, Wending Tang, Lihua Wang, Yannan Bin, Junfeng Xia

Prediction of therapeutic peptide is a significant step for the discovery of promising therapeutic drugs. Most of the existing studies have focused on the mono-functional therapeutic peptide prediction. However, the number of multi-functional therapeutic peptides (MFTP) is growing rapidly, which requires new computational schemes to be proposed to facilitate MFTP discovery. In this study, based on multi-head self-attention mechanism and class weight optimization algorithm... Читать дальше...



Considering humans as habitat reveals evidence of successional disease ecology among human pathogens

Plos.org 
En

by Nina H. Fefferman, Charles A. Price, Oliver C. Stringham

The realization that ecological principles play an important role in infectious disease dynamics has led to a renaissance in epidemiological theory. Ideas from ecological succession theory have begun to inform an understanding of the relationship between the individual microbiome and health but have not yet been applied to investigate broader, population-level epidemiological dynamics. We consider human hosts as habitat and apply... Читать дальше...

Blind spots on western blots: Assessment of common problems in western blot figures and methods reporting with recommendations to improve them

Plos.org 
En

by Cristina Kroon, Larissa Breuer, Lydia Jones, Jeehye An, Ayça Akan, Elkhansa Ahmed Mohamed Ali, Felix Busch, Marinus Fislage, Biswajit Ghosh, Max Hellrigel-Holderbaum, Vartan Kazezian, Alina Koppold, Cesar Alberto Moreira Restrepo, Nico Riedel, Lea Scherschinski, Fernando Raúl Urrutia Gonzalez, Tracey L. Weissgerber

Читать дальше...

[Football] Week 2: Football Players-of-the-Week

Great Plains Athletic Conference Baseball 
En

(Sioux City, Iowa) – The Great Plains Athletic Conference (GPAC) and Hauff Mid-America Sports are proud to announce the following football players-of-the-week for games played the week of September 5-11, 2022.  Hauff Mid-America Sports is the presenting sponsor of the 2022-23 GPAC Players-of-the-Week and Players and Coaches-of-the-Year awards program. 

Kel Mitchell Talks New Book "Prank Day," Nostalgia, & Stepping Out On Faith

Блог сайта «Face Tube is a fun name,» 
En

Kel Mitchell is living a truly blessed life!

It's not often that a person gets to chat it up with one of the most iconic figures from their childhood, and that was the case when TV Fanatic caught up with the '90s icon, comedian, two-time Emmy nominee and all-around ray of sunshine, Kel Mitchell to talk about his latest venture.

While we don't have too much information about the rumors circulating around a Good Burger revival, there was plenty to discuss outside of that, particularly about the debut of his second book... Читать дальше...

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DCT delays implementation of change to free import storage rule by one month

Engineeringnews.co.za 
En

State-owned Transnet Port Terminals’ (TPT’s) Durban Container Terminal (DCT) has extended the date of implementing the changed free import storage rule by one month following what it has called “robust engagements” with its stakeholders last month.   The DCT Pier 2 will now move implementation from September 1 to October 1, while the DCT Pier 1 will move implementation from October 1 to November 1.

Toyota Sequoia Luggage Test: How much fits behind the third row?

Autoblog.com 
En

Filed under: Toyota,Deep Dive,SUV,Hybrid,Driveway Tests

Continue reading Toyota Sequoia Luggage Test: How much fits behind the third row?

Toyota Sequoia Luggage Test: How much fits behind the third row? originally appeared on Autoblog on Mon, 12 Sep 2022 10:00:00 EDT. Please see our terms for use of feeds.

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