by Jean de Dieu Tapsoba, Jane Cover, Christopher Obong’o, Martha Brady, Tim R. Cressey, Kira Mori, Gordon Okomo, Edward Kariithi, Rael Obanda, Daniel Oluoch Madiang, Ying Qing Chen, Paul Drain, Ann Duerr
Читать дальше...
by Tianqi Yang, Ricardo Henao
Determining transcriptional factor binding sites (TFBSs) is critical for understanding the molecular mechanisms regulating gene expression in different biological conditions. Biological assays designed to directly mapping TFBSs require large sample size and intensive resources. As an alternative, ATAC-seq assay is simple to conduct and provides genomic cleavage profiles that contain rich information for imputing TFBSs indirectly. Previous footprint-based tools... Читать дальше...
by David Laloum, Marc Robinson-Rechavi
Many genes have nycthemeral rhythms of expression, i.e. a 24-hours periodic variation, at either mRNA or protein level or both, and most rhythmic genes are tissue-specific. Here, we investigate and discuss the evolutionary origins of rhythms in gene expression. Our results suggest that rhythmicity of protein expression could have been favored by selection to minimize costs. Trends are consistent in bacteria, plants and animals, and are also supported by tissue-specific patterns in mouse. Читать дальше...
by Ye Yuan, Carlos Cosme Jr., Taylor Sterling Adams, Jonas Schupp, Koji Sakamoto, Nikos Xylourgidis, Matthew Ruffalo, Jiachen Li, Naftali Kaminski, Ziv Bar-Joseph
Читать дальше...
by Oscar Silfvergren, Christian Simonsson, Mattias Ekstedt, Peter Lundberg, Peter Gennemark, Gunnar Cedersund
Читать дальше...
by Leo Zeitler, Cyril Denby Wilkes, Arach Goldar, Julie Soutourina
The great advances of sequencing technologies allow the in vivo measurement of nuclear processes—such as DNA repair after UV exposure—over entire cell populations. However, data sets usually contain only a few samples over several hours, missing possibly important information in between time points. We developed a data-driven approach to analyse CPD repair kinetics over time in Saccharomyces cerevisiae. In contrast to other... Читать дальше...
by Gennady Gorin, Meichen Fang, Tara Chari, Lior Pachter
We perform a thorough analysis of RNA velocity methods, with a view towards understanding the suitability of the various assumptions underlying popular implementations. In addition to providing a self-contained exposition of the underlying mathematics, we undertake simulations and perform controlled experiments on biological datasets to assess workflow sensitivity to parameter choices and underlying biology. Finally, we argue for a more rigorous approach to RNA velocity... Читать дальше...
by Ali Hummos, Bin A. Wang, Sabrina Drammis, Michael M. Halassa, Burkhard Pleger
Читать дальше...
by Wenhui Yan, Wending Tang, Lihua Wang, Yannan Bin, Junfeng Xia
Prediction of therapeutic peptide is a significant step for the discovery of promising therapeutic drugs. Most of the existing studies have focused on the mono-functional therapeutic peptide prediction. However, the number of multi-functional therapeutic peptides (MFTP) is growing rapidly, which requires new computational schemes to be proposed to facilitate MFTP discovery. In this study, based on multi-head self-attention mechanism and class weight optimization algorithm... Читать дальше...
by Valerie A. C. M. Koeken, Cancan Qi, Vera P. Mourits, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Vidhisha Sonawane, Heidi Lemmers, Helga Dijkstra, Leo A. B. Joosten, Arjan van Laarhoven, Cheng-Jian Xu, Reinout van Crevel, Mihai G. Netea, Yang Li
Читать дальше...
by Nina H. Fefferman, Charles A. Price, Oliver C. Stringham
The realization that ecological principles play an important role in infectious disease dynamics has led to a renaissance in epidemiological theory. Ideas from ecological succession theory have begun to inform an understanding of the relationship between the individual microbiome and health but have not yet been applied to investigate broader, population-level epidemiological dynamics. We consider human hosts as habitat and apply... Читать дальше...
by Cristina Kroon, Larissa Breuer, Lydia Jones, Jeehye An, Ayça Akan, Elkhansa Ahmed Mohamed Ali, Felix Busch, Marinus Fislage, Biswajit Ghosh, Max Hellrigel-Holderbaum, Vartan Kazezian, Alina Koppold, Cesar Alberto Moreira Restrepo, Nico Riedel, Lea Scherschinski, Fernando Raúl Urrutia Gonzalez, Tracey L. Weissgerber
Читать дальше...Photo by Justin Berl/Getty Images
Going into the off day with a series win over the reigning World Series champs.
Читать дальше...OAKLAND, CALIFORNIA - SEPTEMBER 11: Former Oakland Athletics pitcher Dave Stewart #34 speaks to the fans during the retirement of his jersey number by the Athletics prior to the game against the Chicago White Sox at RingCentral Coliseum on September 11, 2022 in Oakland, California. | Photo by Thearon W. Henderson/Getty Images
MLB news roundup
Читать дальше...
(Sioux City, Iowa) – The Great Plains Athletic Conference (GPAC) and Hauff Mid-America Sports are proud to announce the following football players-of-the-week for games played the week of September 5-11, 2022. Hauff Mid-America Sports is the presenting sponsor of the 2022-23 GPAC Players-of-the-Week and Players and Coaches-of-the-Year awards program.
Photo by Francois Nel/Getty Images
The Club World Cup could be coming to a city or region near you in 2023.
Читать дальше...
Jeffrey Swinger-USA TODAY Sports
The defense shined, but the offense could not finish.
Читать дальше...
Kel Mitchell is living a truly blessed life!
It's not often that a person gets to chat it up with one of the most iconic figures from their childhood, and that was the case when TV Fanatic caught up with the '90s icon, comedian, two-time Emmy nominee and all-around ray of sunshine, Kel Mitchell to talk about his latest venture.
While we don't have too much information about the rumors circulating around a Good Burger revival, there was plenty to discuss outside of that, particularly about the debut of his second book... Читать дальше...
Commercial fishermen, marine-life protectors and tribes are among the groups urging a cautious approach to the turbines.
PPC work doesn't have to mean late-night, last-minute urgent client requests. Learn the seven causes of PPC frenzy and how to avoid them.
Читать дальше...
How do you determine when to invest your time vs. delegating, using a partner or outsourcing?
State-owned Transnet Port Terminals’ (TPT’s) Durban Container Terminal (DCT) has extended the date of implementing the changed free import storage rule by one month following what it has called “robust engagements” with its stakeholders last month. The DCT Pier 2 will now move implementation from September 1 to October 1, while the DCT Pier 1 will move implementation from October 1 to November 1.