Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism
by Shuang Bai, Li Sun, Xi Wang, Shuang-min Wang, Zhou-qing Luo, Yamei Wang, Quan-wen Jin
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by Shuang Bai, Li Sun, Xi Wang, Shuang-min Wang, Zhou-qing Luo, Yamei Wang, Quan-wen Jin
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by Lucie A. Huet, Hannah M. Emnett, Mitra J. Z. Hartmann
The rodent vibrissal (whisker) system has been studied for decades as a model of active touch sensing. There are no sensors along the length of a whisker; all sensing occurs at the whisker base. Therefore, a large open question in many neuroscience studies is how an animal could estimate the three-dimensional (3D) location at which a whisker makes contact with an object. In the present work we simulated the shape of a real rat whisker... Читать дальше...
by Tatjana Petrov, Matej Hajnal, Julia Klein, David Šafránek, Morgane Nouvian
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by Ludmilla Figueiredo, Cédric Scherer, Juliano Sarmento Cabral
The ubiquitous use of computational work for data generation, processing, and modeling increased the importance of digital documentation in improving research quality and impact. Computational notebooks are files that contain descriptive text, as well as code and its outputs, in a single, dynamic, and visually appealing file that is easier to understand by nonspecialists. Traditionally used by data scientists when producing reports and informing decision-making... Читать дальше...
by Michael A. Kelley, Karin Leiderman
Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot. A small fraction of circulating fibrinogen is the variant γA/γ′, which has been associated with high-affinity thrombin binding and implicated as a risk factor for myocardial infarctions, deep vein thrombosis, and coronary artery disease. Читать дальше...
by Nirag Kadakia
Functional forms of biophysically-realistic neuron models are constrained by neurobiological and anatomical considerations, such as cell morphologies and the presence of known ion channels. Despite these constraints, neuron models still contain unknown static parameters which must be inferred from experiment. This inference task is most readily cast into the framework of state-space models, which systematically takes into account partial observability and measurement noise. Читать дальше...
by Jalil Nourisa, Berit Zeller-Plumhoff, Regine Willumeit-Römer
Magnesium (Mg2+) ions are frequently reported to regulate osteogenic activities of mesenchymal stem cells (MSCs). In this study, we propose a numerical model to study the regulatory importance of Mg2+ ions on MSCs osteoblastic differentiation in the presence of an inflammatory response. A fuzzy logic controller was formulated to receive the concentrations of Mg2+ ions and the inflammatory cytokines of TNF-α, IL-10, IL-1β, and... Читать дальше...
by Jess Ramsay, Daniel R. Kattnig
Adult hippocampal neurogenesis and hippocampus-dependent cognition in mice have been found to be adversely affected by hypomagnetic field exposure. The effect concurred with a reduction of reactive oxygen species in the absence of the geomagnetic field. A recent theoretical study suggests a mechanistic interpretation of this phenomenon in the framework of the Radical Pair Mechanism. According to this model, a flavin-superoxide radical pair, born in the singlet spin configuration... Читать дальше...
by Gertjan Bisschop
Extracting information on the selective and demographic past of populations that is contained in samples of genome sequences requires a description of the distribution of the underlying genealogies. Using the Laplace transform, this distribution can be generated with a simple recursive procedure, regardless of model complexity. Assuming an infinite-sites mutation model, the probability of observing specific configurations of linked variants within small haplotype blocks... Читать дальше...
by Alexander Woglar, Marie Pierron, Fabian Zacharias Schneider, Keshav Jha, Coralie Busso, Pierre Gönczy
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by Shuang Peng, Darko Stojkov, Jian Gao, Kevin Oberson, Philipp Latzin, Carmen Casaulta, Shida Yousefi, Hans-Uwe Simon
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by Kai Diederich, Kathrin Schmitt, Philipp Schwedhelm, Bettina Bert, Céline Heinl
Читать дальше...White Glacier has released testing results of its newest survival suit, the Arctic 10+ PC, which was...
Scott Wachter-USA TODAY Sports
RSL was great for 60 minutes and then completely fell apart.
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The ubiquitous US News college rankings attempt to answer an inherently subjective question—“Where should I go to college?”—with hard numbers. While an admirable goal to some extent, the resulting list is anything but objective, and it certainly should not be make-or-break in your college selection process.
There comes a time when we all have to eat a little crow.
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China's Tianwen-3 aims to be the first to collect samples from Mars and deliver them to Earth, potentially landing back home two years ahead of the NASA and the European Space Agency MSR project
Data governance has historically been a serious bottleneck for analytics. While managing data to ensure it complies with policies and regulations is important, these processes can also make it difficult to locate and access data. Businesses that govern data at scale, in real time, and in the cloud often find the situation even more complicated.…
Some projects that launched when muni junk debt surged during the pandemic’s borrowing boom have struggled in a time of rising rates and slowing growth.
AMC’s hit zombie-apocalypse drama “The Walking Dead” is ending this November after a 12-year run on cable TV, but a legal fight over profits from the show continues.
The iPhone 14 Pro and Pro Max make up over 80% of preorders as early adopters lean away from the base iPhone 14. Here's why.
Commentary: I was desperate to quit my first job, but more afraid of going broke.
With rafts as prolific some days as caddis flies and with trout being hooked and released multiple times, many people believe something has to change on the Madison River.
President of the Republic of Azerbaijan Ilham Aliyev has met with President of the Republic of Turkiye Recep Tayyip Erdogan in Samarkand. President Recep Tayyip Erdogan offered condolences to President Ilham Aliyev
Aspen Ladd punching Raquel Pennington at UFC 273 | Photo by Jeff Bottari/Zuffa LLC
Get the scoop on the preliminary action out of UFC Vegas 60, featuring former women’s bantamweight darling Aspen Ladd looking to right her ship against former Olympic wrestler, Sara McMann.
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