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Новости за 07.11.2022

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Determinants of natural adult sleep: An umbrella review

Plos.org 
En

by Nicole Philippens, Ester Janssen, Stef Kremers, Rik Crutzen

Background

Sleep has a major impact on health, which makes it a relevant topic for research and health practitioners. Research on sleep determinants, i.e. factors that positively or negatively influence sleep, is fragmented.

Objective

The purpose of this umbrella review is to provide an overview of the current evidence on determinants of natural adult sleep.

Methods

A comprehensive literature search was performed on determinants of sleep. Читать дальше...

Getting funded in a highly fluctuating environment: Shifting from excellence to luck and timing

Plos.org 
En

by Eneli Kindsiko, Kärt Rõigas, Ülo Niinemets

Recent data highlights the presence of luck in research grant allocations, where most vulnerable are early-career researchers. The national research funding contributes typically the greatest share of total research funding in a given country, fulfilling simultaneously the roles of promoting excellence in science, and most importantly, development of the careers of young generation of scientists. Yet, there is limited supply of studies that have... Читать дальше...

Risk and symptoms of COVID-19 in health professionals according to baseline immune status and booster vaccination during the Delta and Omicron waves in Switzerland—A multicentre cohort study

Plos.org 
En

by Baharak Babouee Flury, Sabine Güsewell, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, Dorette Meier Kleeb, J. Carsten Möller, Philip Rieder, Markus Rütti, Hans-Ruedi Schmid, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli, Ulrike Besold, Allison McGeer, Lorenz Risch, Andrée Friedl, Matthias Schlegel, Stefan P. Kuster, Christian R. Kahlert, Philipp Kohler, on behalf of the SURPRISE Study Group

Читать дальше...

Aging and sperm signals alter DNA break formation and repair in the C. elegans germline

Plos.org 
En

by Erik Toraason, Victoria L. Adler, Diana E. Libuda

Female reproductive aging is associated with decreased oocyte quality and fertility. The nematode Caenorhabditis elegans is a powerful system for understanding the biology of aging and exhibits age-related reproductive defects that are analogous to those observed in many mammals, including dysregulation of DNA repair. C. elegans germline function is influenced simultaneously by both reproductive aging and signals triggered by limited supplies of sperm... Читать дальше...



Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations

Plos.org 
En

by Kodi Taraszka, Noah Zaitlen, Eleazar Eskin

We introduce pleiotropic association test (PAT) for joint analysis of multiple traits using genome-wide association study (GWAS) summary statistics. The method utilizes the decomposition of phenotypic covariation into genetic and environmental components to create a likelihood ratio test statistic for each genetic variant. Though PAT does not directly interpret which trait(s) drive the association, a per trait interpretation of the omnibus p-value... Читать дальше...

Mosaic patterns of selection in genomic regions associated with diverse human traits

Plos.org 
En

by Abin Abraham, Abigail L. LaBella, John A. Capra, Antonis Rokas

Natural selection shapes the genetic architecture of many human traits. However, the prevalence of different modes of selection on genomic regions associated with variation in traits remains poorly understood. To address this, we developed an efficient computational framework to calculate positive and negative enrichment of different evolutionary measures among regions associated with complex traits. We applied the framework... Читать дальше...

Election officials fear counting delays will help fuel claims of fraud - The Washington Post

Top Stories (us) - Google News (ru) 
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  1. Election officials fear counting delays will help fuel claims of fraud  The Washington Post
  2. Here's a breakdown of the shifts we might see as votes are counted in six battleground states  CNN
  3. When We Can Expect Election Results  The New York Times
  4. America's election systems are more than just machines – they're people, who are overworked, underpaid and feeling pressured  Yahoo News
  5. View Full Coverage on Google News

Mammals: Prime Video Drops Trailer for James Corden Drama

Блог сайта «Face Tube is a fun name,» 
En

Prime Video has an exciting new series for fans of James Corden.

The streaming service debuted the official trailer and new images for the upcoming darkly comedic drama series Mammals, starring Tony, Emmy, and BAFTA winner James Corden and Oscar nominee Sally Hawkins.

All six episodes of Mammals will premiere on Friday, November 11, exclusively on Prime Video in more than 240 countries and territories around the world.

The official logline reads as follows:

"In the new Original series... Читать дальше...

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