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Новости за 12.04.2023

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Influences of race and clinical variables on psychiatric genetic research participation: Results from a schizophrenia sample

Plos.org 
En

by Rose Mary Xavier, Yuktha Shanavas, Brian M. Britt, Wales T. George

Advances in genetics has led to a better understanding of both genetic and environmental contributions to psychiatric mental health disorders. But psychiatric genetics research is predominantly Eurocentric, and individuals of non-European ancestry continue to be significantly underrepresented in research studies with potential to worsen existing mental health disparities. The objective of this study was to examine factors... Читать дальше...

Silencing of dentate gyrus inhibits mossy fiber sprouting and prevents epileptogenesis through NDR2 kinase in pentylenetetrazole kindling rat model of TLE

Plos.org 
En

by Chen Zhang, Zixian He, Zheren Tan, Fafa Tian

Epileptogenesis is a potential process. Mossy fiber sprouting (MFS) contributes to epileptogenesis. Silencing of the dentate gyrus (DG) suppressed spontaneous seizures model of epilepsy and hyperactivity of granule cells resulted in MFS in vitro. However, the role of DG’s excitability in epileptogenesis have not yet been well explored, and underlying mechanisms has not been elucidated. Using chemical genetics, we studied whether MFS and epileptogenesis... Читать дальше...

Impact of labor analgesia on mode of delivery and neonatal outcomes in Japan: A retrospective cohort study

Plos.org 
En

by Shu Eguchi, Yuko Nagaoki, Sachiko Ohde, Michio Hirata

Labor analgesia (LA) is associated with the potential hazard of high-risk delivery, such as cesarean section (CS) and instrumental vaginal delivery (IVD), and adverse neonatal outcomes such as neonatal asphyxia and respiratory distress. The objective was to examine the impact of LA on mode of delivery and neonatal outcomes and to counsel pregnant women about a potentially higher risk and allow them to decide LA or non-LA. This retrospective... Читать дальше...



Agency and reward across development and in autism: A free-choice paradigm

Plos.org 
En

by Irene Valori, Laura Carnevali, Teresa Farroni

Our ability to perform voluntary actions and make choices is shaped by the motivation from control over the resulting effects (agency) and from positive outcomes (reward). The underlying action-outcome binding mechanisms rely on sensorimotor abilities that specialise through child development and undergo different trajectories in autism. The study aimed at disentangling the role of agency and reward in driving action selection of autistic and non-autistic children and adults... Читать дальше...

Genomic analysis of two phlebotomine sand fly vectors of leishmania from the new and old World

Plos.org 
En

by Frédéric Labbé, Maha Abdeladhim, Jenica Abrudan, Alejandra Saori Araki, Ricardo N. Araujo, Peter Arensburger, Joshua B. Benoit, Reginaldo Pecanha Brazil, Rafaela V. Bruno, Gustavo Bueno da Silva Rivas, Vinicius Carvalho de Abreu, Jason Charamis, Iliano V. Coutinho-Abreu, Samara G. da Costa-Latgé, Alistair Darby, Viv M. Dillon, Scott J. Emrich, Daniela Fernandez-Medina, Nelder Figueiredo Gontijo, Catherine M. Flanley, Derek Gatherer, Fernando A. Genta, Sandra Gesing, Gloria I. Giraldo-Calderón... Читать дальше...

Correction: A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mulatta) model

Plos.org 
En

by Manutsanun Inthawong, Piyanate Sunyakumthorn, Sirima Wongwairot, Tippawan Anantatat, Susanna J. Dunachie, Rawiwan Im-Erbsin, James W. Jones, Carl J. Mason, Luis A. Lugo, Stuart D. Blacksell, Nicholas P. J. Day, Piengchan Sonthayanon, Allen L. Richards, Daniel H. Paris

Purely STDP-based assembly dynamics: Stability, learning, overlaps, drift and aging

Plos.org 
En

by Paul Manz, Raoul-Martin Memmesheimer

Memories may be encoded in the brain via strongly interconnected groups of neurons, called assemblies. The concept of Hebbian plasticity suggests that these assemblies are generated through synaptic plasticity, strengthening the recurrent connections within select groups of neurons that receive correlated stimulation. To remain stable in absence of such stimulation, the assemblies need to be self-reinforcing under the plasticity rule. Previous models... Читать дальше...

Identifying the engagement of a brain network during a targeted tDCS-fMRI experiment using a machine learning approach

Plos.org 
En

by Anant Shinde, Sovesh Mohapatra, Gottfried Schlaug

Transcranial direct current stimulation (tDCS) can noninvasively modulate behavior, cognition, and physiologic brain functions depending on polarity and dose of stimulation as well as montage of electrodes. Concurrent tDCS-fMRI presents a novel way to explore the parameter space of non-invasive brain stimulation and to inform the experimenter as well as the participant if a targeted brain region or a network of spatially separate brain regions has been engaged and modulated. Читать дальше...

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In the business of base editors: Evolution from bench to bedside

Plos.org 
En

by Elizabeth M. Porto, Alexis C. Komor

With the advent of recombinant DNA technology in the 1970s, the idea of using gene therapies to treat human genetic diseases captured the interest and imagination of scientists around the world. Years later, enabled largely by the development of CRISPR-based genome editing tools, the field has exploded, with academic labs, startup biotechnology companies, and large pharmaceutical corporations working in concert to develop life-changing therapeutics. In this Essay... Читать дальше...

Genomic surveillance urgently needed to control wheat blast pandemic spreading across continents

Plos.org 
En

by Johanna Rhodes

A new study in PLOS Biology highlights the alarming potential of a pandemic clone of wheat blast disease to evolve fungicide-insensitive variants and argues the urgent need for genomic surveillance and preemptive breeding of resistant wheat. This Primer explores a new study in PLOS Biology which describes the alarming potential of a pandemic clone of wheat blast disease to evolve fungicide-insensitive variants, arguing the urgent need for genomic surveillance and pre-emptive breeding of resistant wheat.

The Other Rapinoe

GQ.com 
En

Like her famous twin sister, Megan, Rachael Rapinoe was a huge soccer talent—until injuries and an opioid addiction derailed her career. Now she’s offering athletes a new way to manage their pain.


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