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2023

Новости за 11.08.2023

Effects of non-pharmacological interventions on patients with sarcopenic obesity: A meta-analysis

Plos.org 

by Jiajia Xu, Qingqing Hu, Jiaying Li, Yixi Zhou, Ting Chu

Objective

Systematic evaluation of the improvement effect of non-pharmacological intervention on patients with sarcopenic obesity.

Methods

Wanfang, VIP, China National Knowledge Infrastructure (CNKI), SinoMed, Web of Science, Cochrane Library, PubMed, and Embase databases were searched systematically for randomized controlled trials (RCTS) and experimental studies of non-pharmacological interventions on patients with sarcopenic obesity. Читать дальше...



HIV pre-exposure prophylaxis and incidence of sexually transmitted infections in Brazil, 2018 to 2022: An ecological study of PrEP administration, syphilis, and socioeconomic indicators

Plos.org 

by Paula Knoch Mendonça Gil, Danilo dos Santos Conrado, Ana Isabel do Nascimento, Micael Viana de Azevedo, João Cesar Pereira da Cunha, Gabriel Serrano Ramires Koch, Camila Guadeluppe Maciel, Alisson André Ribeiro, Antonio Conceição Paranhos Filho, Márcio José de Medeiros, Cláudia Du Bocage Santos-Pinto, Everton Falcão de Oliveira

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VarSCAT: A computational tool for sequence context annotations of genomic variants

Plos.org 

by Ning Wang, Sofia Khan, Laura L. Elo

The sequence contexts of genomic variants play important roles in understanding biological significances of variants and potential sequencing related variant calling issues. However, methods for assessing the diverse sequence contexts of genomic variants such as tandem repeats and unambiguous annotations have been limited. Herein, we describe the Variant Sequence Context Annotation Tool (VarSCAT) for annotating the sequence contexts of genomic variants... Читать дальше...

Receptive field sizes and neuronal encoding bandwidth are constrained by axonal conduction delays

Plos.org 

by Tim C. Hladnik, Jan Grewe

Studies on population coding implicitly assume that spikes from the presynaptic cells arrive simultaneously at the integrating neuron. In natural neuronal populations, this is usually not the case—neuronal signaling takes time and populations cover a certain space. The spread of spike arrival times depends on population size, cell density and axonal conduction velocity. Here we analyze the consequences of population size and axonal conduction delays on the stimulus... Читать дальше...

Functional and spatial rewiring principles jointly regulate context-sensitive computation

Plos.org 

by Jia Li, Ilias Rentzeperis, Cees van Leeuwen

Adaptive rewiring provides a basic principle of self-organizing connectivity in evolving neural network topology. By selectively adding connections to regions with intense signal flow and deleting underutilized connections, adaptive rewiring generates optimized brain-like, i.e. modular, small-world, and rich club connectivity structures. Besides topology, neural self-organization also follows spatial optimization principles, such as minimizing... Читать дальше...

Practical sampling of constraint-based models: Optimized thinning boosts CHRR performance

Plos.org 

by Johann F. Jadebeck, Wolfgang Wiechert, Katharina Nöh

Thinning is a sub-sampling technique to reduce the memory footprint of Markov chain Monte Carlo. Despite being commonly used, thinning is rarely considered efficient. For sampling constraint-based models, a highly relevant use-case in systems biology, we here demonstrate that thinning boosts computational and, thereby, sampling efficiencies of the widely used Coordinate Hit-and-Run with Rounding (CHRR) algorithm. By benchmarking CHRR... Читать дальше...

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Москва

Компания «Гранд Сервис Экспресс» на фоне задержки рейсов в столичных аэропортах включила дополнительные купейные вагоны в оба состава поезда №53/54 «Гранд Экспресс» сообщением Санкт-Петербург – Москва и Москва –...



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