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Новости за 21.08.2023

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Public health impact of antihypertensive medication use on arterial blood pressure: A pooled cross-sectional analysis of population health surveys

Plos.org 
En

by Diego Montano

The early initiation of antihypertensive drug therapy is conceived as one of the most important public health interventions addressing cardiovascular risk in the population. However, the actual contribution of this public health intervention to reduce blood pressure (BP) at the population level is largely unknown. Hence, the aim of the present investigation is to estimate the potential public health effects of the use of antihypertensive medication on BP in the population aged 16 and older. Читать дальше...

Does the dual circulation coupling synergy facilitate firm survival?——Evidence from China

Plos.org 
En

by Lijun Ran, Xin Li, Kang Wang, Huihui Liu

The “dual circulation” development pattern is a major economic strategy proposed by China. Using samples gathered from firms located in the Haidian Science and Technology Park in Zhongguancun between 2013 and 2019, this paper constructs an index system for measuring the degree of synergy of the dual circulation coupling of the firms, and then uses the Cloglog survival model to empirically verify its effect on the survival of firms. It is found that... Читать дальше...

Metabolic modeling of sex-specific liver tissue suggests mechanism of differences in toxicological responses

Plos.org 
En

by Connor J. Moore, Christopher P. Holstege, Jason A. Papin

Male subjects in animal and human studies are disproportionately used for toxicological testing. This discrepancy is evidenced in clinical medicine where females are more likely than males to experience liver-related adverse events in response to xenobiotics. While previous work has shown gene expression differences between the sexes, there is a lack of systems-level approaches to understand the direct clinical impact of these differences. Читать дальше...



A subcomponent-guided deep learning method for interpretable cancer drug response prediction

Plos.org 
En

by Xuan Liu, Wen Zhang

Accurate prediction of cancer drug response (CDR) is a longstanding challenge in modern oncology that underpins personalized treatment. Current computational methods implement CDR prediction by modeling responses between entire drugs and cell lines, without the consideration that response outcomes may primarily attribute to a few finer-level ‘subcomponents’, such as privileged substructures of the drug or gene signatures of the cancer cell, thus producing predictions that are hard to explain. Читать дальше...

STREAK: A supervised cell surface receptor abundance estimation strategy for single cell RNA-sequencing data using feature selection and thresholded gene set scoring

Plos.org 
En

by Azka Javaid, Hildreth Robert Frost

The accurate estimation of cell surface receptor abundance for single cell transcriptomics data is important for the tasks of cell type and phenotype categorization and cell-cell interaction quantification. We previously developed an unsupervised receptor abundance estimation technique named SPECK (Surface Protein abundance Estimation using CKmeans-based clustered thresholding) to address the challenges associated with accurate abundance estimation. In that paper... Читать дальше...

Mariners Moose Tracks, 8/21/23: Eugenio Suarez, Kyle Harrison, and Byron Buxton

Lookout Landing 
En

Photo by Bob Levey/Getty Images

Oh how sweep it is.

In Mariners news...

  • Mariners top prospect Lazaro Montes has been on fire lately:

"Man, is this kid fun to watch."

No. 12 @Mariners prospect Lazaro Montes crushes his fourth homer in the past five games for the @ModestoNuts: pic.twitter.com/NPJ6fRkzLS

— Minor League Baseball (@MiLB) August 21, 2023
  • Just your average out to end the inning:

This is a great example of a classic 9-6-2-4-6-3 putout. Читать дальше...

Elephant Rumblings: Ryan Noda expected to be activated today

Athletics Nation 
En

Stan Szeto-USA TODAY Sports

MLB news roundup

Happy Monday, Athletics Nation!

The shellacking continued over the weekend, with the A’s getting swept at home by the AL-leading Baltimore Orioles. The Birds put on a clinic and outscored Oakland 28-7 through all three games. Let’s see if the A’s can get back on track against the far less formidable Royals this week before heading out on the road again.

Much needed help could be on the way, as Martin Gallegos tweeted that... Читать дальше...

10 Steps To Unbeatable And Ethical Strategy Decisions

Paper Blog 
En

Most entrepreneurs are so overwhelmed by the day-to-day challenges of their business that they rarely take the time to work on longer-term strategy (they work in the business versus on the business). As a result, strategy decisions are made in the same ad-hoc crises style as operational decisions, and the business suffers. Gut reactions are rarely the optimal solution to any problem.

Читать дальше...

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Москва

Преимущества автоматики для ворот Came


Webb captures detailed beauty of Ring Nebula

Esa.int 
En

The NASA/ESA/CSA James Webb Space Telescope has observed the well-known Ring Nebula with unprecedented detail. Formed by a star throwing off its outer layers as it runs out of fuel, the Ring Nebula is an archetypal planetary nebula. The object is also known as M57 and NGC 6720, and is relatively close to Earth at roughly 2,500 light-years away.


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