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2023

Новости за 25.09.2023

Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows

Plos.org 

by Ana Catalán, Justin Merondun, Ulrich Knief, Jochen B. W. Wolf

The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid autosomes (AA) and the hemizygous sex chromosome (X). Female heterogametic systems (AAf Zf, AAm ZZm) tend to only show partial dosage compensation (0.5 < Zf:AAf < 1) and dosage... Читать дальше...



Measuring uncertainty in human visual segmentation

Plos.org 

by Jonathan Vacher, Claire Launay, Pascal Mamassian, Ruben Coen-Cagli

Segmenting visual stimuli into distinct groups of features and visual objects is central to visual function. Classical psychophysical methods have helped uncover many rules of human perceptual segmentation, and recent progress in machine learning has produced successful algorithms. Yet, the computational logic of human segmentation remains unclear, partially because we lack well-controlled paradigms to measure perceptual... Читать дальше...

Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid cell guidance

Plos.org 

by Jason P. Town, Orion D. Weiner

To migrate efficiently, neutrophils must polarize their cytoskeletal regulators along a single axis of motion. This polarization process is thought to be mediated through local positive feedback that amplifies leading edge signals and global negative feedback that enables sites of positive feedback to compete for dominance. Though this two-component model efficiently establishes cell polarity, it has potential limitations, including a tendency to “lock” onto a particular direction... Читать дальше...

Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development

Plos.org 

by Jacob P. Brandt, Cody J. Smith

Spontaneous Ca2+ transients of neural cells is a hallmark of the developing nervous system. It is widely accepted that chemical signals, like neurotransmitters, contribute to spontaneous Ca2+ transients in the nervous system. Here, we reveal an additional mechanism of spontaneous Ca2+ transients that is mechanosensitive in the peripheral nervous system (PNS) using intravital imaging of growing dorsal root ganglia (DRG) in zebrafish embryos. GCaMP6s imaging... Читать дальше...

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Москва

Компания «Гранд Сервис Экспресс» на фоне задержки рейсов в столичных аэропортах включила дополнительные купейные вагоны в оба состава поезда №53/54 «Гранд Экспресс» сообщением Санкт-Петербург – Москва и Москва –...


Neighbours Spoilers for the Week of 9-25-23: Harold's Heartbreaking Storyline Begins

Блог сайта «Face Tube is a fun name,» 

Oh no, not Harold!

The elderly, endearing character is one of Neighbours' most iconic residents. Besides being a rich source of Ramsey Street history, he's also one of the few Erinsborough residents to return from the dead.

But according to spoilers for Neighbours during the week of 9-25-23, Karl begins to worry that there's something more to Harold's recent memory lapses than meets the eye. Could this be the beginning of the end for Harold?

Harold's memory problems... Читать дальше...

Global Appetite For Canadian Crude Grows Amidst Supply Cuts

Oilprice.com 

Last week, Canada's Prime Minister pledged to the UN General Assembly that he would cap emissions from the country's oil and gas industry this year. Interestingly, the only leaders allowed to speak at the gathering were those who had made firm climate change commitments, and even though Trudeau was among them, he was criticized for the fact that "Canada was one of the largest expanders of fossil fuels last year," per a CBC report. To the UN general assembly's horror, Canada continues to be "an expander" this year as well. Читать дальше...


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