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2024

Новости за 26.01.2024

Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage and pulmonary hypertension through Sirtuin 1 signaling

Plos.org 

by Hanhan Liu, Zhou Pan, Xiaofeng Wu, Cheng Gong, Junbo Hu

Notch pathway has played a significant role in the pathophysiology of pulmonary hypertension (PH). However, the role of Jagged 2 (Jag2), one ligand of Notch, remains to be elucidated.Therefore, determining the contribution of Jag2 to PH and its impact on pulmonary artery smooth muscle cells (PASMCs) was the aim of this investigation. Adeno-associated virus-mediated Jag2 inhibition was used to explore the role of Jag2 in peripheral... Читать дальше...

Automatic classification of sleep stages using EEG signals and convolutional neural networks

Plos.org 

by Ihssan S. Masad, Amin Alqudah, Shoroq Qazan

Sleep stages classification is one of the new topics in studying human life quality because it plays a crucial role in getting a healthy lifestyle. Abnormal changes or absence of normal sleep may lead to different diseases such as heart-related diseases, diabetes, and obesity. In general, sleep staging analysis can be performed using electroencephalography (EEG) signals. This study proposes a convolutional neural network (CNN) based methodology... Читать дальше...

In quest of China sports lottery development path to common prosperity in 2035

Plos.org 

by Yaping Yao, Bin Wan, Bo Long, Te Bu, Yang Zhang

Objectives

The China sports lottery contributes to sports and welfare causes. This study aims to construct a macro forecasting model supporting its sustained growth aligned with Vision 2035.

Methods

The modeling employed a distributional regression. Sales data of the China sports lottery from 2011 to 2022 were chosen as the response variable, alongside various macro- and event-level explanatory factors.

Results

A gamma distribution best fit the data. Читать дальше...



Authenticity: Effective emotional labor strategies on teaching efficacy of university teachers in China

Plos.org 

by Jiuhua Zheng, Yuqing Geng, Juan Gao, Qinjun Xiang

Based on the job demands-resources model, this study explored the relationships among emotional labor strategies, job demands of teaching, job resources, and teaching efficacy for university teachers. The results, based on a sample of 316 university teachers from China, showed that the teachers preferred to convey authenticity by expressing deep acting and naturally felt emotion. Furthermore, deep acting and naturally felt emotions were... Читать дальше...

Safety and efficacy of bempedoic acid among patients with statin intolerance and those without: A meta-analysis and a systematic randomized controlled trial review

Plos.org 

by Yi Li, Hongyu Gao, Jinghui Zhao, Liqing Ma, Dan Hu

Objective

Bempedoic acid, an innovative oral medication, has garnered significant interest in recent times due to its potential as a therapeutic intervention for hypercholesterolemia. Nonetheless, the outcomes of the initial investigations might have been more definitive and coherent. Our objective was to perform a quantitative meta-analysis in order to evaluate bempedoic acid’s safety and effectiveness.

Methods

A search was conducted on ClinicalTrials.gov... Читать дальше...

Short-term Hebbian learning can implement transformer-like attention

Plos.org 

by Ian T. Ellwood

Transformers have revolutionized machine learning models of language and vision, but their connection with neuroscience remains tenuous. Built from attention layers, they require a mass comparison of queries and keys that is difficult to perform using traditional neural circuits. Here, we show that neurons can implement attention-like computations using short-term, Hebbian synaptic potentiation. We call our mechanism the match-and-control principle and it proposes that when activity in an axon is synchronous... Читать дальше...


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