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Новости за 30.01.2024

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Prevalence and determinants of multimorbidity in the Canadian population

Plos.org 
En

by Xiang Xiao, Jeremy Beach, Ambikaipakan Senthilselvan

Multimorbidity, which is defined as having at least two or more chronic diseases concurrently, has been a rising public health issue in recent years in Canada and worldwide. The increasing prevalence of multimorbidity has posed a burden on the current health care system and quality of life for the Canadian population. There is a lack of up-to-date research on determinants of multimorbidity in the Canadian population, which is necessary... Читать дальше...

Analyst coverage and manufacturing enterprise green transition: An empirical study based on Chinese enterprises

Plos.org 
En

by Jianfei Leng, Jianqin Hu

This study used the entropy weight method to develop an index of green transition and empirically examined the influence of analyst coverage on green transitions by manufacturing enterprises in China. We examined A-share listed manufacturing firms from 2010–2020, using patent data, media reports from Chinese Research Data Services, and other data from the Cathay Capital Database. After excluding cases with missing data, our final sample comprised 16,576 observations. Читать дальше...



Nurse-led self-care interventions for older adults with multiple chronic conditions: A protocol for a systematic review and network meta-analysis

Plos.org 
En

by Heejung Choi, GyeongAe Seomun

The importance of self-care interventions is progressively recognized, marked by a rapidly aging population that results in growing demands on costly tertiary and institutional care services, placing substantial pressure on health and social care systems. Against this background, in this study, we will provide evidence for the impact of self-care interventions on health-related quality of life by focusing on interventions led by nurses who can employ integrated approaches. Читать дальше...

Conversion of spikers to bursters in pituitary cell networks: Is it better to disperse for maximum exposure or circle the wagons?

Plos.org 
En

by Mehran Fazli, Richard Bertram

The endocrine cells of the pituitary gland are electrically active, and in vivo they form small networks where the bidirectional cell-cell coupling is through gap junctions. Numerous studies of dispersed pituitary cells have shown that typical behaviors are tonic spiking and bursting, the latter being more effective at evoking secretion. In this article, we use mathematical modeling to examine the dynamics of small networks of spiking and bursting pituitary cells. Читать дальше...

Spatial and temporal heterogeneity alter the cost of plasticity in Pristionchus pacificus

Plos.org 
En

by Ata Kalirad, Ralf J. Sommer

Phenotypic plasticity, the ability of a single genotype to produce distinct phenotypes under different environmental conditions, has become a leading concept in ecology and evolutionary biology, with the most extreme examples being the formation of alternative phenotypes (polyphenisms). However, several aspects associated with phenotypic plasticity remain controversial, such as the existence of associated costs. While already predicted by some of the pioneers of plasticity research... Читать дальше...

A neural network model for the evolution of learning in changing environments

Plos.org 
En

by Magdalena Kozielska, Franz J. Weissing

Learning from past experience is an important adaptation and theoretical models may help to understand its evolution. Many of the existing models study simple phenotypes and do not consider the mechanisms underlying learning while the more complex neural network models often make biologically unrealistic assumptions and rarely consider evolutionary questions. Here, we present a novel way of modelling learning using small neural networks and a simple, biology-inspired learning algorithm. Читать дальше...

AutoEdge-CCP: A novel approach for predicting cancer-associated circRNAs and drugs based on automated edge embedding

Plos.org 
En

by Yaojia Chen, Jiacheng Wang, Chunyu Wang, Quan Zou

The unique expression patterns of circRNAs linked to the advancement and prognosis of cancer underscore their considerable potential as valuable biomarkers. Repurposing existing drugs for new indications can significantly reduce the cost of cancer treatment. Computational prediction of circRNA-cancer and drug-cancer relationships is crucial for precise cancer therapy. However, prior computational methods fail to analyze the interaction between circRNAs... Читать дальше...

Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS

Plos.org 
En

by Md Amin Hossain, Richa Sarin, Daniel P. Donnelly, Brandon C. Miller, Alexandra Weiss, Luke McAlary, Svetlana V. Antonyuk, Joseph P. Salisbury, Jakal Amin, Jeremy B. Conway, Samantha S. Watson, Jenifer N. Winters, Yu Xu, Novera Alam, Rutali R. Brahme, Haneyeh Shahbazian, Durgalakshmi Sivasankar, Swathi Padmakumar, Aziza Sattarova, Aparna C. Ponmudiyan, Tanvi Gawde, David E. Verrill, Wensheng Yang, Sunanda Kannapadi, Leigh D. Plant, Jared R. Auclair, Lee Makowski, Gregory A. Petsko, Dagmar Ringe, Nathalie Y. Читать дальше...

Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants

Plos.org 
En

by Timothy W. Russell, Hermaleigh Townsley, Sam Abbott, Joel Hellewell, Edward J. Carr, Lloyd A. C. Chapman, Rachael Pung, Billy J. Quilty, David Hodgson, Ashley S. Fowler, Lorin Adams, Chris Bailey, Harriet V. Mears, Ruth Harvey, Bobbi Clayton, Nicola O’Reilly, Yenting Ngai, Jerome Nicod, Steve Gamblin, Bryan Williams, Sonia Gandhi, Charles Swanton, Rupert Beale, David L. V. Bauer, Emma C. Wall, Adam J. Kucharski

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