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Новости за 16.02.2024

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Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming

Plos.org 
En

by Josh Jones, Qiaojuan Shi, Rahul R. Nath, Ilana L. Brito

Fusobacterium nucleatum (Fn) and enterotoxigenic Bacteroides fragilis (ETBF) are two pathobionts consistently enriched in the gut microbiomes of patients with colorectal cancer (CRC) compared to healthy counterparts and frequently observed for their direct association within tumors. Although several molecular mechanisms have been identified that directly link these organisms to features of CRC in specific cell types, their specific... Читать дальше...

Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells

Plos.org 
En

by Allaura A. Cox, Alice Liu, Christopher J. Ng

Alterations in von Willebrand factor (VWF) have an important role in human health and disease. Deficiency of VWF is associated with symptoms of bleeding and excesses of VWF are associated with thrombotic outcomes. Understanding the mechanisms that drive VWF regulation can lead to a better understanding of modulation of VWF levels in humans. We identified clusterin (CLU) as a potential candidate regulator of VWF based on a single cell RNA sequencing... Читать дальше...



Does the openness of the Boundary Shell system influence the sustainable development of the high-tech industry?

Plos.org 
En

by Yiming Shi, Qingmei Tan, Zhi Liu, Ge Yang, Min Zhang

High-technology industries have gained substantial recognition as pivotal drivers of economic growth and technological advancement in modern society. The imperative of sustainable development in high-tech industries cannot be overemphasized, as it plays a crucial role in enabling long-term growth, fostering innovation, and assuming environmental responsibility. This article presents a study on sustainable development in high-tech industries using Boundary Shell theory. Читать дальше...

Gut microbiome diversity and function during hibernation and spring emergence in an aquatic frog

Plos.org 
En

by Ji-Eun Lee, Jun-Kyu Park, Yuno Do

The gut microbiota maintains a deeply symbiotic relationship with host physiology, intricately engaging with both internal (endogenous) and external (exogenous) factors. Anurans, especially those in temperate regions, face the dual challenges of significant external influences like hibernation and complex internal variances tied to different life histories. In our research, we sought to determine whether different life stages (juvenile versus adult) of... Читать дальше...

Key factors capturing the willingness to use automated vehicles for travel in China

Plos.org 
En

by Yongjiang Zhou, Hanying Guo, Hongguo Shi, Siyi Jiang, Yang Liao

With the continuous advancement of technology, automated vehicle technology is progressively maturing. It is crucial to comprehend the factors influencing individuals’ intention to utilize automated vehicles. This study examined user willingness to adopt automated vehicles. By incorporating age and educational background as random parameters, an ordered Probit model with random parameters was constructed to analyze the influential... Читать дальше...

Women decision making on use of modern family planning methods and associated factors, evidence from PMA Ethiopia

Plos.org 
En

by Fitsum Tariku Fantaye, Solomon Abrha Damtew

Background

Family planning decision making is defined as women´s ability to determine the family planning methods that she wanted to use through the process of informed decision making. Despite the availability and accessibility of family planning methods, the utilization rate is not more than 41% in Ethiopia. Evidence and experts have consistently show that women decisions making ability on family planning method they desired to use is one... Читать дальше...

Data-driven mathematical simulation analysis of emergency evacuation time in smart station’s operations management

Plos.org 
En

by Yang Hui, Qiang Yu, Hui Peng

This research establishes an emergency evacuation time model specifically designed for subway stations with complex structures. The model takes into account multiple factors, including passenger flow rate, subway facility parameters, and crowd density, to accurately assess evacuation times. It considers the impact of horizontal walking distance, flow rate, subway train size, and stair parameters on the overall evacuation process. By identifying bottleneck points such as gates... Читать дальше...

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Enhancing misinformation correction: New variants and a combination of awareness training and counter-speech to mitigate belief perseverance bias

Plos.org 
En

by Jana Siebert, Johannes Ulrich Siebert

Belief perseverance bias refers to individuals’ tendency to persevere in biased opinions even after the misinformation that initially shaped those opinions has been retracted. This study contributes to research on reducing the negative impact of misinformation by mitigating the belief perseverance bias. The study explores the previously proposed awareness-training and counter-speech debiasing techniques, further developing them by introducing new variants and combining them. Читать дальше...

Elimination of lymphatic filariasis as a public health problem in Malawi

Plos.org 
En

by John Chiphwanya, Square Mkwanda, Storn Kabuluzi, Themba Mzilahowa, Bagrey Ngwira, Dorothy E. Matipula, Limbikani Chaponda, Paul Ndhlova, Prince Katchika, Chawananga Mahebere Chirambo, Philemon Moses, Justin Kumala, Martin Chiumia, Carrie Barrett, Hannah Betts, Joan Fahy, Maria Rebollo Polo, Lisa Reimer, Michelle C. Stanton, Brent Thomas, Sian Freer, David H. Molyneux, Moses J. Bockarie, Charles D. Mackenzie, Mark J. Taylor, Sarah Martindale, Louise A. Kelly-Hope

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COVID-19 diagnostic testing and vaccinations among First Nations in Manitoba: A nations-based retrospective cohort study using linked administrative data, 2020–2021

Plos.org 
En

by Nathan C. Nickel, Wanda Phillips-Beck, Jennifer E. Enns, Okechukwu Ekuma, Carole Taylor, Sarah Fileatreault, Nkiru Eze, Leona Star, Josée Lavoie, Alan Katz, Marni Brownell, Alyson Mahar, Marcelo Urquia, Dan Chateau, Lisa Lix, Mariette Chartier, Emily Brownell, Miyosha Tso Deh, Anita Durksen, Razvan Romanescu

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