Even small increases in out-of-pocket costs for preexposure prophylaxis (PrEP), a medication that can prevent people from being infected with HIV, could result in patients not filling their prescriptions, a recent study in Health Affairs projected.
Being diagnosed with depression during or after pregnancy was associated with an increased risk of death up to 18 years later from any cause, according to data from more than 86 000 Swedish women with the condition.
People in the UK who did not receive all the doses of the vaccine for which they were eligible had up to 4 times the risk of being hospitalized or dying from COVID-19 compared with those who were fully vaccinated, according to electronic health record data taken from the entire population aged 5 years or older. Rates of undervaccination ranged from about 33% to almost 50% across the UK, with the highest rates in Northern Ireland.
Researchers have turned to machine learning algorithms to help find biomarkers that could identify people with major depressive disorder (MDD). But these algorithms were only able to accurately identify up to 62% of people with MDD using neuroimaging data, a study involving more than 1800 participants aged 18 to 65 years found.
Poll results from more than 2600 respondents found that about 8% of adults aged 50 to 80 years reported using an online-only direct-to-consumer health care service. This may increase though. About one-third of the respondents expressed interest in using these services in the future, the University of Michigan’s National Poll on Healthy Aging found.
People who spent much of their day at work sitting had a 16% higher risk of dying from any cause and a 34% higher mortality risk from cardiovascular disease compared with those who didn’t spend as much time sitting on the job, according to a cohort study in JAMA Network Open. After the study’s roughly 13-year surveillance of about 480 000 participants, researchers also found that people who mostly sat during the day but increased their physical activity by an extra 15 to 30 minutes had a similar... Читать дальше...
A new rule finalized by the US Centers for Medicare & Medicaid Services (CMS) streamlines the prior authorization process, which requires clinicians to seek permission from insurers before prescribing certain treatments to patients. The rule applies to insurance providers including Medicare Advantage organizations and Medicaid programs, which have until January 1, 2027, to implement the requirements.
This clinical trial compares the effectiveness of anticoagulation vs antiplatelet therapy for secondary stroke prevention in patients with cryptogenic stroke and evidence of atrial cardiopathy.
It can be counterintuitive for patients with atrial fibrillation (AF) to understand the evidence-based recommendation to receive anticoagulation therapy despite successful suppression of their arrhythmia with an antiarrhythmic drug. After all, the general teaching is that the heightened risk of stroke and systemic thromboemboli occurs due to the stasis of blood in the left atrial appendage produced during rapid and disorganized fibrillation of atrial tissue. And yet, randomized clinical trial data... Читать дальше...
This Review summarizes current evidence regarding the diagnosis and treatment of paroxysmal supraventricular tachycardia.
A sign the clinician elicits —importantly distinct from pain, which is concerned with feeling— my textbook insists.
This cohort study of renters who received eviction filings, similar renters who did not, and the general population across the study area compares rates of excess mortality associated with the COVID-19 pandemic.
In Reply We thank Mr Meng and colleagues and Dr Park and colleagues for their comments about the EMERGE trial. We agree with using caution in the interpretation of the trial, as the primary outcome did not reach the prespecified level of statistical significance. However, the constituents of the primary outcome (insulin initiation or a mean fasting glucose level of ≥5.1 mmol/L at weeks 32 and 38) were significantly improved in those randomized to metformin. In addition, secondary outcomes of maternal insulin dose... Читать дальше...
In Reply Dr Boull and colleagues raise important points in their Letter. Our recent Review noted the absence of randomized clinical trials testing the efficacy of the Children’s Oncology Group Long-Term Follow-Up Guidelines (COG LTFU Guidelines) in mitigating the risk of adverse treatment-related outcomes. The lack of randomized clinical trials is not limited to skin cancer but applies to all recommendations within the COG LTFU Guidelines. Given the relatively small absolute numbers of childhood... Читать дальше...
To the Editor A recent study concluded that early metformin treatment for gestational diabetes was not superior to placebo for the composite primary outcome. However, we have several concerns. First, the authors defined the primary outcome as a composite of insulin initiation before delivery or fasting blood glucose exceeding 5.1 mmol/L at week 32 or week 38 of gestation. Some studies have used different criteria, including new insulin initiation, increased use of glucose-lowering medications, or specific blood glucose measurements. Читать дальше...
To the Editor We read with interest the Review that detailed common subsequent health complications in childhood cancer survivors. The authors accurately highlighted basal cell carcinoma as an important secondary neoplasm in recipients of radiation therapy; however, childhood cancer survivors are also at risk of melanoma and squamous cell carcinoma, which, unlike basal cell carcinoma, can become invasive and metastasize. Chemotherapy alone and primary diagnoses of leukemia or lymphoma have been associated with increased risk of melanoma. Читать дальше...
Jules Voncken, M.D., Liége, Belgium
Evictions have become recognized as important social determinants of individual and community health, largely due to the revelatory work of Desmond in the past decade. During the COVID-19 pandemic, evictions became a major public health topic as the Centers for Disease Control and Prevention (CDC) issued a federal moratorium on evictions that lasted from September 4, 2020, through August 26, 2021. The moratorium was instituted with the intention to limit COVID-19 transmission by preventing homelessness and overcrowded housing conditions. Читать дальше...
Responding to the government's draft Rail Reform Bill, RMT general secretary Mick Lynch said:
Date: 02/20/2024
Player: Christophe Lalancette (F)
From: Mountfield HK
Information: For 2024/25
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Date: 02/20/2024
Player: Curtis Hall (F)
From: Maine Mariners
To: Providence Bruins
Information: Recalled
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Date: 02/20/2024
Player: Logan Stankoven (F)
From: Texas Stars
To: Dallas Stars
Information: Recalled
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Date: 02/20/2024
Player: Alexander Petrovic (D)
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To: Texas Stars
Information: Reassigned
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Date: 02/20/2024
Player: Mason Lohrei (D)
From: Providence Bruins
To: Boston Bruins
Information: Recalled
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Date: 02/20/2024
Player: Oskar Steen (F)
From: Boston Bruins
To: Providence Bruins
Information: Reassigned
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