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Новости за 04.06.2024

Non–HDL-C Levels From Childhood to Adulthood and CVD Events

Jamanetwork.com 

This study of individual participant data from 6 pooled cohorts assesses whether resolution of elevated childhood non–high-density lipoprotein cholesterol (non–HDL-C) by adulthood is associated with reduced risk of clinical cardiovascular disease (CVD) events.

A Review of Thyroid Cancer—Reply

Jamanetwork.com 

In Reply We appreciate letters about our Review on thyroid cancer. In response to the comments by Drs Beheshtirouy and Shayanfar, the causal association between GLP-1 RA use and thyroid cancer is complex and requires careful consideration of factors that directly or indirectly influence carcinogenesis pathways such as the direct biological effects of the drug, host susceptibility factors (eg, obesity or proinflammatory states), biases embedded in clinical trials, and length of follow-up. To date... Читать дальше...

A Review of Thyroid Cancer

Jamanetwork.com 

To the Editor A recent Review discussed the complexity of thyroid cancer. First, we would like to highlight the importance of distinguishing between benign and malignant thyroid nodules preoperatively.



Fritz Kahn and the Centenary of the Doctor of the Future

Jamanetwork.com 

This JAMA Arts and Medicine feature describes ways in which Fritz Kahn shared a prescient and nuanced vision of technology’s role in the patient-physician interaction, a topic of continued interest and relevance today, through his illustrations.

Safeguarding Research Using Federal Health Insurance Data

Jamanetwork.com 

This Viewpoint discusses the importance of researcher access to federal health care data following a CMS decision to limit the use of physical data and proposes solutions to maintain access and security.

Denosumab-Associated Severe Hypocalcemia in Dialysis-Dependent Patients—Reply

Jamanetwork.com 

In Reply We thank Drs Schoenmakers and Fraser for their comments on our study. We reported the US experience with denosumab administration among dialysis-dependent patients, finding the weighted cumulative incidence of severe hypocalcemia (ie, <7.5 mg/dL or emergent care) at 12 weeks to be 41.1% with denosumab. We agree that treatment for osteoporosis in our study may have been initiated in some patients with poorly controlled CKD-MBD, highlighting the importance of increased attention to careful patient selection in clinical practice. Читать дальше...

A 3-Year-Old With Gingival Hemorrhage and Musculoskeletal Pain

Jamanetwork.com 

A 3-year-old had spontaneous gingival hemorrhage and bilateral limb weakness with inability to bear weight. He had no preceding oral trauma or recent infection, took no regular medications, and had no recent use of aspirin or nonsteroidal anti-inflammatory drugs; his diet was limited to primarily chicken nuggets and milk. What is the diagnosis and what would you do next?

Best Versions of Ourselves

Jamanetwork.com 

In this narrative medicine essay, a lecturer in narrative medicine strives to accept her best self by surmounting the barriers of itchy skin and unsightly red patches caused by chronic atopic dermatitis.

The “Day of Rest” and Human Efficiency

Jamanetwork.com 

The refreshing influence of the weekly recurring “day of rest” on a person subjected to the strenuous routine of a busy life is a feature which he himself can duly appreciate in terms of his “feelings” and “spirits.” If it is desired to demonstrate the need of such relaxation and the benefits derived therefrom in some objective way, a method is not easily forthcoming. The problem is one which, in its broadest aspects, has a far-reaching importance in every community. The efficiency of the working man... Читать дальше...

Новости России
Москва

Праздник 23 Февраля в ТРЦ «Нора»


Service Animals in Health Care Settings

Jamanetwork.com 

This JAMA Insights article reviews Americans with Disabilities Act (ADA) rules for patients, visitors, and other members of the public bringing service animals into health care settings.

PhALLCON Soars to New Heights—Faster, Stronger, but Better?

Jamanetwork.com 

In this issue of JAMA, Jabbour and colleagues report results from the interim analysis of the PhALLCON randomized trial with ponatinib vs imatinib, combined with reduced-intensity chemotherapy. They found ponatinib to have superior efficacy and a comparable safety profile for frontline treatment of adults with newly diagnosed Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL). On the heels of these results, the US Food and Drug Administration granted ponatinib accelerated approval for this indication on March 19, 2024.

Meaning of Proposed Causal Inference Framework for the JAMA Network

Jamanetwork.com 

The Special Communication “Causal Inferences About the Effects of Interventions From Observational Studies in Medical Journals,” published in this issue of JAMA, provides a rationale and framework for considering causal inference from observational studies published by medical journals. Our intent is to invite discussion of this framework, explore its application in the context of specific study designs, and actively examine how this framework could be implemented and used by authors, peer reviewers... Читать дальше...


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