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Новости за 07.06.2024

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Strong association between genomic 3D structure and CRISPR cleavage efficiency

Plos.org 
En

by Shaked Bergman, Tamir Tuller

CRISPR is a gene editing technology which enables precise in-vivo genome editing; but its potential is hampered by its relatively low specificity and sensitivity. Improving CRISPR’s on-target and off-target effects requires a better understanding of its mechanism and determinants. Here we demonstrate, for the first time, the chromosomal 3D spatial structure’s association with CRISPR’s cleavage efficiency, and its predictive capabilities. We used high-resolution... Читать дальше...

Swimming in a school shelters fish from turbulence

Plos.org 
En

by Tyson L. Hedrick

Much has been written about the energetic effects of animals moving in schools or flocks, but experimental results are few and often ambiguous. A new study in PLOS Biology shows that schooling greatly reduces the cost of transport for fish in turbulent flow. Much has been written about the energetic effects of animals moving in schools or flocks, but experimental results are few and often ambiguous. This Primer explores a new study in PLOS Biology which shows that schooling... Читать дальше...

Examining the causal relationship between sex hormone-binding globulin (SHBG) and infertility: A Mendelian randomization study

Plos.org 
En

by Hanghao Ma, Yan Chen

Background

The causal relationship between sex hormone-binding globulin (SHBG) and infertility has remained unclear. Thus, we used Mendelian randomization (MR) to investigate this relationship.

Methods

Risk factors for SHBG were extracted from European individuals within the UK Biobank using single-nucleotide polymorphism (SNP) data. Summary-level data for infertility outcomes were obtained from the FinnGen dataset. The causal relationship between SHBG and... Читать дальше...



Exploration of the shared pathways and common biomarker in adamantinomatous craniopharyngioma and type 2 diabetes using integrated bioinformatics analysis

Plos.org 
En

by Yibo Han, Yong Wang, Shuo Li, Kohji Sato, Satoru Yamagishi

Craniopharyngiomas are rare tumors of the central nervous system that typically present with symptoms such as headache and visual impairment, and those reflecting endocrine abnormalities, which seriously affect the quality of life of patients. Patients with craniopharyngiomas are at higher cardiometabolic risk, defined as conditions favoring the development of type 2 diabetes and cardiovascular disease. However, the underlying... Читать дальше...

Aspects of spermatogenesis in immature and mature specimens of the long-lived Greenland shark: Novelties concerning the germinal compartment’s assembly, complement of Sertoli cells and demise

Plos.org 
En

by Leon Mendel McClusky, Julius Nielsen, Jørgen Schou Christiansen

Cystic spermatogenesis in the subadult, maturing and adult Greenland shark (Somniosus microcephalus) displays multiple novel features, characterized early on by an unorganized internal cellular environment of the spermatocysts (anatomically discrete follicle-like units containing a single germ cell stage and its complement of co-developing Sertoli cells). These typically show polar asymmetries due to asymmetrically distributed germ and Sertoli cells. Читать дальше...

Unveiling the adoption of metaverse technology in Bangkok metropolitan areas: A UTAUT2 perspective with social media marketing and consumer engagement

Plos.org 
En

by Chaloempon Sritong, Weerachon Sawangproh, Teerapong Teangsompong

As the metaverse emerges as a transformative digital realm, its adoption and integration into various aspects of society are subjects of increasing scholarly and practical interest. This research investigated the factors influencing the intention to use metaverse technology (IU) in Bangkok metropolitan areas, with a particular focus on the extended Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) framework, alongside... Читать дальше...

A pharmacist-led interprofessional medication adherence program improved adherence to oral anticancer therapies: The OpTAT randomized controlled trial

Plos.org 
En

by Carole Bandiera, Evelina Cardoso, Isabella Locatelli, Khalil Zaman, Antonella Diciolla, Antonia Digklia, Athina Stravodimou, Valérie Cristina, Veronica Aedo-Lopez, Ana Dolcan, Apostolos Sarivalasis, Hasna Bouchaab, Jérôme Pasquier, Jennifer Dotta-Celio, Solange Peters, Dorothea Wagner, Chantal Csajka, Marie Paule Schneider

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Herbal oral care products for the prevention of ventilator-associated pneumonia: A systematic review and network meta-analysis of randomised trials

Plos.org 
En

by SuWen Li, YanNan Huang, HongYin Xie

Background

The recommendation for Chlorhexidine (CHX) as a traditional oral care solution is decreasing, and herbal oral care products are being considered as a potential alternative. This network meta-analysis aims to determine if herbal oral care products for oral care in mechanically ventilated patients are superior to CHX and provide direction for future research by comparing the effectiveness of herbal oral care products currently available.

... Читать дальше...

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Comparison of Foraging Interactive D-prime and Angular Indication Measurement Stereo with different methods to assess stereopsis

Plos.org 
En

by Sonisha Neupane, Jan Skerswetat, Peter J. Bex

Purpose

Stereopsis is a critical visual function, however clinical stereotests are time-consuming, coarse in resolution, suffer memorization artifacts, poor repeatability, and low agreement with other tests. Foraging Interactive D-prime (FInD) Stereo and Angular Indication Measurement (AIM) Stereo were designed to address these problems. Here, their performance was compared with 2-Alternative-Forced-Choice (2-AFC) paradigms (FInD Stereo only)... Читать дальше...


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