France’s national auditor sounds alarm over public finances
Eurozone’s second-largest economy is ‘dangerously exposed’ to new crisis after failing to control deficits and debt
Eurozone’s second-largest economy is ‘dangerously exposed’ to new crisis after failing to control deficits and debt
Tech expert Kurt “CyberGuy" Knutsson talks about how to secure your accounts and monitor credit if your number is found on the dark web.
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An eye-opening talk was given to Cannock and District Ladies Probus Club, when Finn (previously a Puppy Walker), shared the journey of a guide dog. Guide Dogs for The Blind Association, now known as Guide Dogs, formed after WW1 when servicemen returned blind.
A trio of physicists and oceanologists, two with the University of Cologne's Institute of Geophysics and Meteorology and the third with the GEOMAR Helmholtz Center for Ocean Research Kiel, all in Germany, has found via the CESM1 climate model that an extreme El Niño tipping point could be reached in the coming decades under current emissions.
The dynamic between parents and their children is one of the most complex living things - on or off the screen. It's common to see...
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by Hashim Ali, David Noyvert, Jacqueline Hankinson, Gemma Lindsey, Aleksei Lulla, Valeria Lulla
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by Vickie A. Marshall, Elena M. Cornejo Castro, Charles A. Goodman, Nazzarena Labo, Isabella Liu, Nicholas C. Fisher, Kyle N. Moore, Ananthakrishnan Nair, Taina Immonen, Brandon F. Keele, Mark N. Polizzotto, Thomas S. Uldrick, Yunxiang Mu, Tanuja Saswat, Laurie T. Krug, Kevin M. McBride, Kathryn Lurain, Ramya Ramaswami, Robert Yarchoan, Denise Whitby
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by Masayuki Shimojima, Satoko Sugimoto, Satoshi Taniguchi, Takahiro Maeki, Tomoki Yoshikawa, Takeshi Kurosu, Shigeru Tajima, Chang-Kweng Lim, Hideki Ebihara
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by Haomin Huang, Shenghai Chang, Tao Cui, Man Huang, Jiuxin Qu, Huimin Zhang, Ting Lu, Xing Zhang, Chun Zhou, Youjun Feng
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by Youngsin Kim, Mihyung Moon, Seokwhwan Moon, Wonkyu Moon
This work investigates whether inclusion of the low-frequency components of heart sounds can increase the accuracy, sensitivity and specificity of diagnosis of cardiovascular disorders. We standardized the measurement method to minimize changes in signal characteristics. We used the Continuous Wavelet Transform to analyze changing frequency characteristics over time and to allocate frequencies appropriately between the low-frequency and audible frequency bands. Читать дальше...
by Sheela B. Abraham, Farah Al-Marzooq, Lakshman Samaranayake, Rifat Akram Hamoudi, Wan Harun Himratul-Aznita, Hany Mohamed Aly Ahmed
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by Aina Astorch-Cardona, Lionel Bertaux, Yann Denis, Alain Dolla, Céline Rommevaux
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by Mideksa Adugna Koricho, Girmaye Deye Dinsa, Nelisiwe Khuzwayo
IntroductionPerformance Based Financing (PBF) supports realization of universal health coverage by promoting bargaining between purchasers and health service providers through identifying priority services and monitoring indicators. In PBF, purchasers use health statistics and information to make decisions rather than merely reimbursing invoices. In this respect, PBF shares certain elements of strategic health purchasing. Читать дальше...
by Japan Huynh, Thi Minh Hue Phan
This study explores the effects of banking uncertainty on firms’ debt financing. Employing data from 2007 to 2022 of Vietnam–a bank-based economy, we document that banking uncertainty negatively impacts corporate debt. The impact firmly holds across various debt maturities and sources, with the most predominant driver witnessed in bank debt. We also investigate the potential underlying mechanism linking banking uncertainty to debt financing, thereby validating the working of three crucial channels... Читать дальше...
by Mira Jung, Nicole Nicholas, Scott Grindrod, Anatoly Dritschilo
Dual-targeting chromatin regulation and DNA damage repair signaling presents a promising avenue for cancer therapy. Applying rational drug design, we synthesized a potent dual-targeting small molecule, SP-1-303. Here, we report SP-1-303 as a class I isoform selective histone deacetylase (HDAC) inhibitor and an activator of the ataxia-telangiectasia mutated protein (ATM). In vitro enzymatic assays demonstrated selective inhibition of HDAC1 and HDAC3. Читать дальше...
by Mélodie A. Nasr, Annette Aldous, Jason Daniels, Christopher Joy, Eleanor Capozzi, Michelle Yang, Patricia Moriarty, Vanessa Emmanuel-Baker, Sharyn Malcolm, Stefan J. Green, Veronica Gomez-Lobo, Mimi Ghosh
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by Camilla S. A. Davan-Wetton, Trinidad Montero-Melendez
Lipofuscin is a yellow-brown pigment typically found in the lysosomes that contains a mixture of molecules including lipids, metals and misfolded proteins. The use of Sudan black B to detect lipofuscin accumulation, a well described marker of cellular senescence and ageing, was first described in 2013 by Georgakopoulou, et al. Here, we provide an optimisation of the original protocol. Firstly, we adjusted the staining methodology for increased ease of use on cultured cells. Читать дальше...
by Ève-Marie Lavallée-Bourget, Christopher Fernandez-Prada, Ariane Massé, Patricia Turgeon, Julie Arsenault
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by Bin Xu, MengNi Jiang, Yu Wei, Ran Duan, Feng Tong
ObjectiveThe aim of this study was to investigate the association between sleep duration and muscle quality index (MQI) in middle-aged and older age groups, as limited evidence exists on this topic.
MethodsIn order to assess the relationship between sleep duration and MQI, a cross-sectional study was undertaken, utilizing data from the National Health and Nutrition Examination Survey (NHANES) acquired during the period from 2011 to 2014. Читать дальше...