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Новости за 17.07.2024

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Polygenic selection to a changing optimum under self–fertilisation

Plos.org 
En

by Matthew Hartfield, Sylvain Glémin

Many traits are polygenic, affected by multiple genetic variants throughout the genome. Selection acting on these traits involves co–ordinated allele–frequency changes at these underlying variants, and this process has been extensively studied in random–mating populations. Yet many species self–fertilise to some degree, which incurs changes to genetic diversity, recombination and genome segregation. These factors cumulatively influence how polygenic selection is realised in nature. Читать дальше...

When size matters: A novel compact Cas12a variant for in vivo genome editing

Plos.org 
En

by Felix Bubeck, Dirk Grimm

A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors. Adopting Cas12a nucleases for AAV-based gene therapy has been difficult due to their large size. A new study in PLOS Biology characterizes and engineers a new Cas12a nuclease variant that is compatible for... Читать дальше...

Bold predictions for MLB's second half: Mets make blockbuster trade, regular season ends with tiebreaker, more - CBS Sports

Top Stories (us) - Google News (com) 
En

  1. Bold predictions for MLB's second half: Mets make blockbuster trade, regular season ends with tiebreaker, more  CBS Sports
  2. 2024 MLB second-half projections, World Series chances: How the playoff races are shaping up - The Athletic  The New York Times
  3. With 24 teams in playoff hunt, players excited for second half  KFGO
  4. MLB Second-Half Bets To Make: Don't Back Judge For AL MVP  Odds Shark News
  5. MLB 2nd Half Bold Predictions: Pick to Win Division  247Sports



Trade Policy Review: China

World Trade Organization 
En

The ninth review of the trade policies and practices of China takes place on 17 and 19 July 2024. The basis for the review is a report by the WTO Secretariat and a report by the Government of China.

Improving communication and promoting social inclusion for hearing-impaired users: Usability evaluation and design recommendations for assistive mobile applications

Plos.org 
En

by Hyeonsu Kim, Heetae Hwang, Sojung Gwak, Jihyeon Yoon, Kyudong Park

This study examines the usability of communication-assistive applications for hearing-impaired users, with a focus on enhancing user experience and promoting social inclusion. Although such applications have been developed and evaluated previously, interface designs that consider the intimacy needs of hearing-impaired users remain under-explored. We performed a comprehensive usability evaluation employing a mixed-method approach... Читать дальше...

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Москва

Плату за парковку машин отменили в Москве на время новогодних праздников


Effects of indoor plants on CO2 concentration, indoor air temperature and relative humidity in office buildings

Plos.org 
En

by Junzhiwei Jiang, Peter Irga, Robert Coe, Philip Gibbons

This experimental study investigates the influence of indoor plants on three aspects of air quality in office spaces: relative humidity, indoor air temperature, and carbon dioxide concentration. Employing a Latin square design, we rotated three different treatments across three offices over six time periods. These treatments included a control (no plants), a low-volume treatment (five plants), and a high-volume treatment (eighteen plants) of Nephrolepis exaltata (Boston fern). Читать дальше...

Barriers and facilitators of early postpartum modern contraceptive method uptake in Dessie and Kombolcha City zones, northeast Ethiopia: Conventional content analysis qualitative study

Plos.org 
En

by Niguss Cherie, Muluemebet Abera Wordofa, Gurmesa Tura Debelew

Background

Despite progress in access to family planning services in many sub-Saharan African countries in recent decades, advances in effective early postpartum contraceptive adoption remain low, and the unmet need for early postpartum contraceptives is high. In Ethiopia, early postpartum modern contraceptive method uptake is still unacceptably low. The barriers/challenges have not yet been sufficiently explored. A deep and... Читать дальше...


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