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Новости за 22.08.2024

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A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans

22.08.2024 17:00

Plos.org

by Shaonil Binti, Adison G. Linder, Philip T. Edeen, David S. Fay

Protein tyrosine phosphatases non-receptor type (PTPNs) have been studied extensively in the context of the adaptive immune system; however, their roles beyond immunoregulation are less well explored. Here we identify novel functions for the conserved C. elegans phosphatase PTPN-22, establishing its role in nematode molting, cell adhesion, and cytoskeletal regulation. Through a non-biased genetic screen, we found that loss... Читать дальше...

Signatures of hierarchical temporal processing in the mouse visual system

22.08.2024 17:00

Plos.org

by Lucas Rudelt, Daniel González Marx, F. Paul Spitzner, Benjamin Cramer, Johannes Zierenberg, Viola Priesemann

iCRBP-LKHA: Large convolutional kernel and hybrid channel-spatial attention for identifying circRNA-RBP interaction sites

22.08.2024 17:00

Plos.org

by Lin Yuan, Ling Zhao, Jinling Lai, Yufeng Jiang, Qinhu Zhang, Zhen Shen, Chun-Hou Zheng, De-Shuang Huang

An empirical appraisal of eLife’s assessment vocabulary

22.08.2024 17:00

Plos.org

by Tom E. Hardwicke, Sarah R. Schiavone, Beth Clarke, Simine Vazire

Research articles published by the journal eLife are accompanied by short evaluation statements that use phrases from a prescribed vocabulary to evaluate research on 2 dimensions: importance and strength of support. Intuitively, the prescribed phrases appear to be highly synonymous (e.g., important/valuable, compelling/convincing) and the vocabulary’s ordinal structure may not be obvious to readers. We conducted an online... Читать дальше...

Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

22.08.2024 17:00

Plos.org

by Weichen Zhou, Kalpita R. Karan, Wenjin Gu, Hans-Ulrich Klein, Gabriel Sturm, Philip L. De Jager, David A. Bennett, Michio Hirano, Martin Picard, Ryan E. Mills

The ion channel Anoctamin 10/TMEM16K coordinates organ morphogenesis across scales in the urochordate notochord

22.08.2024 17:00

Plos.org

by Zonglai Liang, Daniel Christiaan Dondorp, Marios Chatzigeorgiou

During embryonic development, tissues and organs are gradually shaped into their functional morphologies through a series of spatiotemporally tightly orchestrated cell behaviors. A highly conserved organ shape across metazoans is the epithelial tube. Tube morphogenesis is a complex multistep process of carefully choreographed cell behaviors such as convergent extension, cell elongation, and lumen formation. The identity of... Читать дальше...

Mariners Moose Tracks, 8/22/24: Joey Votto, Jurickson Profar, and Mike Shildt

22.08.2024 17:00

Lookout Landing

Kareem Elgazzar/The Enquirer / USA TODAY NETWORK

I’m still sad that we never saw Joey Votto as a Mariner in those final couple of years.

Elephant Rumblings: Pruitt, Logjams, Canesco, plus a Wilson update

22.08.2024 17:00

Athletics Nation

Cary Edmondson-USA TODAY Sports

MLB news roundup

Good morning A’s fans! Time to rise and shine.

The A’s fell to the Tampa Bay Rays in last night’s contest, though since it’s a four-game series the club still has a chance at splitting the series. It wasn’t all bad in the close 4-2 loss as Rule 5 rookie Mitch Spence set a career-high in strikeouts, JJ Bleday hit his 17th home run, and we also got a successful MLB debut from the last remaining piece of the Chris Bassitt trade. Читать дальше...

Something new, something blue

22.08.2024 17:00

Royals Review

Andy Abeyta/The Desert Sun / USA TODAY NETWORK

The Royals are hot

Activist Investor Calls for Forward Air to Consider Sale

22.08.2024 17:00

SourcingJournal.com

Ancora, which owns a 4 percent stake in Forward, stated the case to the company's board that it would function better in the private market.

Jeff Bezos May Be the Owner of a New $80 Million Gulfstream Jet

22.08.2024 17:00

RobbReport.com

The new flagship G700 becomes the third intercontinental jet in the Amazon founder's hangar, if reports are correct, with a regional jet thrown in for short hops.

How to use Google Search Console to unlock easy SEO wins

22.08.2024 17:00

SearchEngineLand.com

Steps for using GSC to review your traffic, analyze the search landscape and make impactful optimizations for quick results.

Squid Have Tiny Teeth In Their Suckers That Could Help Make Self-Healing Materials

22.08.2024 17:00

Discovermagazine.com

"Squid sucker teeth have some outstanding properties."

Are digital currencies experiencing an 'electric vehicles' moment?

22.08.2024 17:00

Americanbanker.com

As with EVs, digital money was a niche product for years before gaining widespread acceptance. Now, digital blockchain-based monies might be on the verge of a major breakthrough.

Infection of human organoids supports an intestinal niche for Chlamydia trachomatis

22.08.2024 17:00

Plos.org

by Pargev Hovhannisyan, Kathrin Stelzner, Markus Keicher, Kerstin Paprotka, Mastura Neyazi, Mindaugas Pauzuolis, Waled Mohammed Ali, Karthika Rajeeve, Sina Bartfeld, Thomas Rudel

The assembly of neutrophil inflammasomes during COVID-19 is mediated by type I interferons

22.08.2024 17:00

Plos.org

by Luz E. Cabrera, Suvi T. Jokiranta, Sanna Mäki, Simo Miettinen, Ravi Kant, Lauri Kareinen, Tarja Sironen, Jukka-Pekka Pietilä, Anu Kantele, Eliisa Kekäläinen, Hanna Lindgren, Pirkko Mattila, Anja Kipar, Olli Vapalahti, Tomas Strandin

Characterization of Entamoeba fatty acid elongases; validation as targets and provision of promising leads for new drugs against amebiasis

22.08.2024 17:00

Plos.org

by Fumika Mi-ichi, Hiroshi Tsugawa, Tam Kha Vo, Yuto Kurizaki, Hiroki Yoshida, Makoto Arita

Recent secondary contact, genome-wide admixture, and asymmetric introgression of neo-sex chromosomes between two Pacific island bird species

22.08.2024 17:00

Plos.org

by Elsie H. Shogren, Jason M. Sardell, Christina A. Muirhead, Emiliano Martí, Elizabeth A. Cooper, Robert G. Moyle, Daven C. Presgraves, J. Albert C. Uy

HTC’s Viverse announces no-code virtual world builder

22.08.2024 17:00

VentureBeat.com

HTC, the maker of the HTC Vive virtual reality headsets, said its Viverse platform has created a no-code virtual world builder.

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Mark Hamill's 'Star Wars' Heartbreak: Luke Skywalker Star Haunted by Feeling Heart Was Ripped Out of Franchise With Carrie Fisher's Death

22.08.2024 17:00

The National Enquirer

Mark Hamill has opened up about how Carrie Fisher's December 2016 death affected the "heart" of the Star Wars franchise.

You Might Think More Police Surveillance Means More Safety. There Are Several Problems With That.

22.08.2024 17:00

The Big Money

You cannot protect people from harm if part of what you offer them is a different kind of harm.

Brain Scans Reveal Aging Patterns Based on Disease, Alcohol and Smoking

22.08.2024 17:00

Scientific American

Brain scan study hints that methods could be developed to detect the earliest stages of neurodegenerative disease

It’s scary when your webcam turns on and you don’t know why

22.08.2024 17:00

PC World

Your webcam turns on for no reason. Why? The idea that some unknown eyeball might be watching you might make you nervous. It did me — which is why I’m telling you how to solve that problem.