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2024

Новости за 17.09.2024

Rosebud

Jamanetwork.com 

I saw an aged woman adorned by those she loved and my heart wondered. She couldn’t tell if she was dying or perhaps had died already but she knew about journeys— that we are only borne far by those we hold.

Surrogate Markers and Clinical Outcomes—Reply

Jamanetwork.com 

In Reply Dr Siegel and colleagues at the FDA raise concerns that our article incorrectly indicated that the FDA relies only on meta-analyses to establish surrogacy and “incorrectly identifies the evidence the FDA used to conclude that these biomarkers can serve as surrogate end points.” However, nowhere in the article did we state that the FDA relies only on meta-analyses to establish the surrogacy of a biomarker for a clinical outcome.

Surrogate Markers and Clinical Outcomes

Jamanetwork.com 

To the Editor Dr Wallach and colleagues evaluated the association between surrogate markers listed in the FDA surrogate end point table and clinical outcomes for 32 chronic diseases, including gout. In accordance with 2 published meta-analyses, the authors concluded urate levels are a weak surrogate marker for gout flares. They also indicated that reducing urate levels may worsen pain in people with gout. An explanation of these findings is needed to avoid confusion in gout management.

American-ish

Jamanetwork.com 

In this narrative medicine essay, a pediatric infectious disease physician relates how he has learned to understand the protective role of code-shifting in his life and how that understanding has aided him in promoting an inclusive environment in academic medicine.

Financing of Hospital Care

Jamanetwork.com 

The modern hospital has evolved from a publicly supported institution which gave institutional and domiciliary care to the poor and unfortunate when they were sick to a complex intricate organization which serves a variety of purposes in the field of health. The hospital has evolved from an institution usually supported by the community or government to one maintained by private agencies and philanthropies and by the fees of persons in the community with the greatest financial resources.…Modern medicine... Читать дальше...



Reasons for Walking Differ Among Groups in the US

Jamanetwork.com 

More adults in the US walk for recreation than walk to work or to a specific destination, a data brief from the National Center for Healthcare Statistics found. The data, which were based on results from the 2022 National Health Interview Survey, also showed demographic and socioeconomic differences.

Study: Methotrexate May Have Potential to Treat Arthritis Pain

Jamanetwork.com 

A randomized, double-blind study of 155 participants with knee osteoarthritis found that those who received oral methotrexate had significantly reduced pain and improved stiffness after 6 months compared with those taking a placebo. The participants’ average age was about 61 years and all lived in the UK.

Current Shingles Vaccine Associated With Lower Risk of Dementia

Jamanetwork.com 

In October 2017, the US Food and Drug Administration approved the recombinant shingles vaccine (marketed as Shingrix) as a replacement for the live-virus vaccine because it was more effective at protecting people aged 50 years or older against herpes zoster, or shingles. Now an observational study in Nature Medicine suggests it may offer better protection against dementia too.

Whooping Cough Cases Rise in Latin America and the US in 2024

Jamanetwork.com 

In July, the Pan American Health Organization/World Health Organization (PAHO/WHO) issued an alert amid the rise of pertussis, also known as whooping cough, in countries across the Americas, including Brazil, Mexico, Peru, and the US.

Widespread SARS-CoV-2 Exposure Among Wildlife in the US

Jamanetwork.com 

SARS-CoV-2, the virus that causes COVID-19, has previously been identified in certain species of wildlife, including white-tailed deer. But new research in Nature Communications suggests it may be common in other types of wildlife, especially species living near high-trafficked human areas.

Amid Bird Flu Cases, CDC Issues Emergency Use Instructions for Tamiflu

Jamanetwork.com 

The US Centers for Disease Control and Prevention (CDC) released emergency use instructions for the antiviral drug oseltamivir, which is sold as Tamiflu. The guidelines detail directions for treatment or postexposure prevention of infection with novel influenza A viruses, which spread among animals and gave rise to the highly pathogenic avian influenza A(H5N1), or H5N1 bird flu.

Kit makes CRISPR education affordable and accessible

Stanford University 

The gene-editing technology is one of the biggest biology advances of the last two decades. An inexpensive kit developed by Stanford undergraduates brings hands-on experiments to high school classrooms.

Move-In Day in pictures

Stanford University 

Stanford welcomed more than 4,500 frosh and transfer, graduate, and professional students to campus for the 2024-25 academic year. See the highlights.

Move-in Day for the Class of 2028

Stanford University 

Stanford welcomed more than 4,500 frosh and transfer, graduate, and professional students to campus for the 2024-25 academic year. Watch the highlights.


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