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2024

Новости за 28.10.2024

Open House / As Arquitectura + Diseño

Archdaily.com 

This is a residential house of approximately 340 m² located in the Aldea Zamá community in Tulum, Quintana Roo. The project features a design that always seeks the integration of exterior and interior spaces, creating patios that articulate the spaces and allow views to flow through them towards the rest of the land, which preserves the native vegetation without being altered.

Balancing acts: The posttranslational modification tightrope of flavivirus replication

Plos.org 

by RuthMabel Boytz, Maudry Laurent-Rolle

Posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes. Many viruses have developed sophisticated mechanisms to modulate these host PTMs, either by inhibiting the interferon pathway or by enhancing the stability and function of viral proteins essential for replication. In this Pearl, we review the literature... Читать дальше...

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I

Plos.org 

by Jiaoyang Li, Jing Zhang, Pu Sun, Jian Wang, Guoxiu Li, Zhanding Cui, Dong Li, Hong Yuan, Tao Wang, Kun Li, Xingwen Bai, Zhixun Zhao, Yimei Cao, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Zaixin Liu, Shuqi Xiao, Xinglong Wang, Zengjun Lu

Читать дальше...



Associations of the TyG index with albuminuria and chronic kidney disease in patients with type 2 diabetes

Plos.org 

by Xiaonan Li, Yuehui Wang

Objective

Diabetes-related kidney disease reduces patients’ quality of life, increases the risk of death, and is associated with insulin resistance (IR). The triglyceride-glucose (TyG) index is a simple and inexpensive alternative to IR measurement. Furthermore, the relationship between albuminuria and chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) remains unclear. Therefore, we aimed to investigate the association of TyG index with albuminuria and CKD in patients with T2DM. Читать дальше...

Exploring the impact on contact adhesion layer properties in numerical simulations

Plos.org 

by Reza Shamim

This paper presents a comprehensive investigation into the impact of key parameters on contact adhesion layer properties using numerical simulations, addressing fundamental questions in contact mechanics. Aiming to explore interfacial penetration and contact pressure dynamics between a wavy punch and an adhesive-coated body, the study focuses on the influence of adhesive layer thickness, elasticity modulus, and punch geometry on mechanical behavior. The study includes the application... Читать дальше...

Новости России
Москва

Театр «Модерн» представит спектакль межгалактического масштаба


Modeling the seasonal wildfire cycle and its possible effects on the distribution of focal species in Kermanshah Province, western Iran

Plos.org 

by Maryam Morovati, Peyman Karami

Predicting environmental disturbances and evaluating their potential impacts on the habitats of various plant and animal species is a suitable strategy for guiding conservation efforts. Wildfires are a type of disturbance that can affect many aspects of an ecosystem and its species. Therefore, through the integration of spatial models and species distribution models (SDMs), we can make informed predictions of the occurrence of such phenomena and their potential impacts. Читать дальше...

Overlapping community detection in weighted networks via hierarchical clustering

Plos.org 

by Petr Prokop, Pavla Dráždilová, Jan Platoš

In real-world networks, community structures often appear as tightly connected clusters of nodes, with recent studies suggesting a hierarchical organization where larger groups subdivide into smaller ones across different levels. This hierarchical structure is particularly complex in trade networks, where actors typically belong to multiple communities due to diverse business relationships and contracts. To address this complexity, we present a... Читать дальше...

Pediatric cancer mortality: Analyzing early deaths and fatalities in a resource-limited tertiary care context

Plos.org 

by Ahmed Farrag, Amira Mahmoud Osman, Mohamed Hamdy Ghazaly

Introduction

Children with suspected cancer may succumb to their bad condition shortly after admission, even before a definitive diagnosis can be reached. We aimed to address the issue of delayed presentation and early deaths among children suspected of having cancer. We analyzed also the types and causes of mortalities across different tumor types.

Materials and methods

A retrospective review of reports from newly admitted... Читать дальше...

Effects of Artemisia asiatica ex on Akkermansia muciniphila dominance for modulation of Alzheimer’s disease in mice

Plos.org 

by Mijung Lee, Kwang-Sung Ahn, Manho Kim

The gut microbiome influences neurological disorders through bidirectional communication between the gut and the brain, i.e., the gut-brain axis. Artemisia asiatica ex, an extract of Artemisia asiatica Nakai (Stillen®, DA-9601) has been reported to improve depression by increasing brain-derived neurotropic factor. Therefore, we hypothesized that DA-9601 can be a potential therapeutic candidate for Alzheimer’s disease (AD) acting through the gut-brain axis. Читать дальше...


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Новости тенниса
Australian Open

Соболенко — третий год подряд в финале в Австралии. Арина подобралась к величию Граф и Селеш






Надрез на любовь. Москвички меняют судьбу операциями на ладони

Минстрой изменит порядок оплаты отопления

Герой России Белоглазов и представители вузов Росгвардии поздравили МГУ с 270-летием

Снега будет по пояс: синоптики предупреждают — такой зимы Россия не видела 100 лет